Cell Biology

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Glioblastoma tumor cells mimic neurons to evade treatment

Certain cancers are more difficult to treat because they contain cells that are highly skilled at evading drugs or our immune systems by disguising themselves as healthy cells.

11 Jan 2024

Study identifies distinct CD4+ T cell changes in various autoimmune diseases

Much like ripples on the water can betray powerful currents below the surface, small changes in our bodies can sometimes be an indicator of a serious condition.

11 Jan 2024

Scientists identify critical protein complex for targeted cancer treatment

The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched.

11 Jan 2024

3D mini-organs from human fetal brain tissue unlock new frontier in brain research

Scientists have developed 3D mini-organs from human fetal brain tissue that self-organize in vitro. These lab-grown organoids open up a brand-new way of studying how the brain develops.

8 Jan 2024

Unraveling the brain-fat pathway that dictates aging in mice

In recent years, research has begun to reveal that the lines of communication between the body's organs are key regulators of aging.

8 Jan 2024

First-of-its-kind research shines light on how certain pathogens can outwit the body's immune system

In a first-of-its-kind research breakthrough, a team of scientists at the University of Massachusetts Amherst has analyzed and described what they call the "mosquito effect," which sheds light on how certain pathogens, such as cancerous tumor cells, can outwit the body's immune system.

8 Jan 2024

Bacterial "freight elevator" unpacked: How pathogens hide from the immune system

Some bacterial membrane transporters work almost like freight elevators to transport substances through the cell membrane into the interior of the cell. The transporter itself spans the bacterial membrane.

8 Jan 2024

AI reveals hidden rules of cell neighborhoods in cancer

Researchers from Children's Hospital of Philadelphia have developed a new AI-powered algorithm to help understand how different cells organize themselves into particular tissues and communicate with one another.

8 Jan 2024

YAP and TAZ proteins guide bone development in the womb

A pair of proteins, YAP and TAZ, has been identified as conductors of bone development in the womb and could provide insight into genetic diseases such as osteogenesis imperfecta, known commonly as "brittle bone disease."

4 Jan 2024

USC scientists develop first all-human brain organoids model of the cerebellum with functional neurons

In a first for USC Stem Cell scientists, the laboratory of Giorgia Quadrato, an assistant professor of stem cell biology and regenerative medicine, has pioneered a novel human brain organoid model that generates all the major cell types of the cerebellum, a hindbrain region predominantly made up of two cell types necessary for movement, cognition, and emotion: granule cells and Purkinje neurons.

4 Jan 2024

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins-;and ultimately affect aging.

4 Jan 2024

New method illuminates intricate interactions of the synaptonemal complex in nematodes

We have two copies of each chromosome in every cell in our bodies except in our reproductive cells. Sperm and egg cells contain a single copy of each chromosome with a unique mix of genes from our parents, an evolutionary trick to give our offspring genetic variability.

3 Jan 2024

Cytonemes: The "express subways" of the developing nervous system

St. Jude Children's Research Hospital scientists found that cytonemes (thin, long, hair-like projections on cells) are important during neural development.

3 Jan 2024

Scripps scientists develop powerful method to find drug targets in live cells

Identifying new ways to target proteins involved in human diseases is a priority for many researchers around the world.

2 Jan 2024

Understanding acylspermidines' secrets could lead to treatments for various diseases

In a significant advancement in the field of biochemistry, scientists at the Boyce Thompson Institute (BTI) and Cornell University have uncovered new insights into a family of metabolites, acylspermidines, that could change how we understand aging and fight diseases.

2 Jan 2024

Scientists take a major step towards realizing synthetic CO2 fixing pathways in living cells

Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2).

2 Jan 2024

Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.

2 Jan 2024

A protein identified as key player in keeping cells tidy

Just as healthy organs are vital to our well-being, healthy organelles are vital to the proper functioning of the cell.

2 Jan 2024

Mettl3 guides CD8 T cells to eliminate infected cells with maximum efficiency

This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr. Xuguang Du (College of Biological Sciences, China Agricultural University) and illustrated the key role of Mettl3 in CD8 T cell response during acute infection model.

29 Dec 2023

Common inflammation pathway turns anthrax toxin into killer

Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system.

26 Dec 2023

Cell Biology

Glioblastoma tumor cells mimic neurons to evade treatment

Study identifies distinct CD4+ T cell changes in various autoimmune diseases

Scientists identify critical protein complex for targeted cancer treatment

3D mini-organs from human fetal brain tissue unlock new frontier in brain research

Unraveling the brain-fat pathway that dictates aging in mice

First-of-its-kind research shines light on how certain pathogens can outwit the body's immune system

Bacterial "freight elevator" unpacked: How pathogens hide from the immune system

AI reveals hidden rules of cell neighborhoods in cancer

YAP and TAZ proteins guide bone development in the womb

USC scientists develop first all-human brain organoids model of the cerebellum with functional neurons

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

New method illuminates intricate interactions of the synaptonemal complex in nematodes

Cytonemes: The "express subways" of the developing nervous system

Scripps scientists develop powerful method to find drug targets in live cells

Understanding acylspermidines' secrets could lead to treatments for various diseases

Scientists take a major step towards realizing synthetic CO2 fixing pathways in living cells

Small molecule-switchable RNA platform enables control of therapeutic protein expression

A protein identified as key player in keeping cells tidy

Mettl3 guides CD8 T cells to eliminate infected cells with maximum efficiency

Common inflammation pathway turns anthrax toxin into killer

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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