Cell Biology

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Cellular RNA enhances MAVS signalosome activation in antiviral immunity

Scientists have uncovered a new role for a cell's own RNA in fending off attacks by RNA viruses. Some of the cell's RNA molecules, researchers found, help regulate antiviral signaling. These signals are part of the intricate coordination of immune responses against virus invasion.

19 Dec 2024

SMART software offers new solution for modeling cell-signaling networks

Researchers at University of California San Diego have developed and tested a new software package, called Spatial Modeling Algorithms for Reactions and Transport (SMART), that can realistically simulate cell-signaling networks - the complex systems of molecular interactions that allow cells to respond to diverse cues from their environment.

19 Dec 2024

Innovative method to study ALS could lead to personalized treatments

Amyotrophic lateral sclerosis (ALS) is a fast-progressing neurodegenerative disease with an average survival time of three years.

19 Dec 2024

New approach in fighting leukemia with double-modified natural killer cells

Various forms of blood cancer exist – all of which are grouped together under the term leukemia. One common form of leukemia is acute myeloid leukemia (AML), characterized by a degradation of early blood cell precursors, i.e. stem cells and the precursor cells that develop from them.

18 Dec 2024

Space experiment shows faster maturation of brain organoids in microgravity

Microgravity is known to alter the muscles, bones, the immune system and cognition, but little is known about its specific impact on the brain.

18 Dec 2024

Scientists discover key protein that helps cancer cells evade CAR T cell therapy

Scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, have collared a tricky culprit that helps cancer cells evade CAR T cell therapy.

17 Dec 2024

CNIC team develops a comprehensive set of genetic tools and mouse lines

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a comprehensive set of innovative genetic tools and mouse lines, called iFlpMosaics, designed to enhance the study of gene function and its implications in health and disease.

14 Dec 2024

Study links intermittent fasting to slower hair growth

Intermittent fasting has proven benefits for metabolic health, but a new study shows that it could slow hair growth - at least in mice.

13 Dec 2024

New protein platform enhances cancer immunotherapy

Researchers from Children's Hospital of Philadelphia (CHOP) and Stanford University have revealed the molecular structure of TRACeR-I, a protein platform for reprogramming immune responses. A better understanding of its structure may help optimize designs for the platform, which can be used to develop cancer treatments by either directly modifying immune cells or by creating proteins that help immune cells locate cancer cells. The findings were published today by the journal Nature Biotechnology.

13 Dec 2024

Disrupting the circadian rhythm of glioblastoma slows tumor growth, study says

Virtually every cell in the human body has an internal clock. These clocks take their cues from a central clock in the brain. In a normal, biological process called synchrony, the central clock coordinates daily rhythms around the body, so that every cell and tissue recognizes the same external time of day.

13 Dec 2024

A genetic variant modulates interferon signaling and disease risk

For years, scientists have looked to a critical piece of immune system machinery - known as the interferon pathway - for answers. There, when our cells sense an infection, they release a protein known as interferon, which warns other cells to fight the virus.

13 Dec 2024