Cell Biology

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Study reveals how B cells safeguard high-affinity antibodies

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

19 Mar 2025

Research findings solve the paradox of how the immune system balances speed and precision

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check.

19 Mar 2025

New tool visualizes immune response to abnormal DNA

A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases.

19 Mar 2025

Small intestine grows in response to pregnancy in mice

Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare for a second.

19 Mar 2025

Most in-depth simulation of brain metabolism yet reveals new targets for future dementia treatments

The findings come from the most comprehensive computer model of brain metabolism to date, which incorporates more than 16,800 biochemical interactions between proteins and chemicals across brain cells, supporting cells, and the blood.

19 Mar 2025

AI-based neural network revolutionizes cancer treatment predictions

A first-of-its-kind artificial intelligence (AI)-based neural network can rapidly analyze and interpret millions of cells from a patient sample, predicting molecular changes in the tissue.

18 Mar 2025

Beckman Coulter Life Sciences launches industry-first modular spectral flow cytometry solution

Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, and an Operating Company of Danaher Corporation, revolutionizes spectral flow cytometry with the industry’s first modular solution: the CytoFLEX mosaic Spectral Detection Module.

From Beckman Coulter Life Sciences - Flow Cytometry 18 Mar 2025

In the Thymus We Trust: ProTcell Therapy & the Future of Allogeneic Immunotherapy

In this interview, News Medical speaks with Olivier Negre, Chief Scientific Officer at Smart Immune, about how immunotherapy is being revolutionized.

From Hanson Wade Group - 7th Allogeneic Cell Therapies Summit 18 Mar 2025

Mitochondria may hold key to reducing inflammaging in aging cells

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.

14 Mar 2025

Study unveils mechanisms behind antigenic variation in pathogens

A new study by LMU and Helmholtz Munich shows how pathogens control changes in their cell surface to evade the immune system.

14 Mar 2025

New laboratory tool identifies viruses to combat Staphylococcus aureus

A newly developed laboratory tool can, within hours, help to identify specific viruses which can be used to destroy variants of the dangerous pathogenic bacteria Staphylococcus aureus.

14 Mar 2025

New lab-grown pig retinal organoids could aid stem cell-based vision therapy

Inside the human eye, the retina is made up of several types of cells, including the light-sensing photoreceptors that initiate the cascade of events that lead to vision.

13 Mar 2025

MIT engineers develop efficient method to convert skin cells into neurons

Converting one type of cell to another - for example, a skin cell to a neuron - can be done through a process that requires the skin cell to be induced into a "pluripotent" stem cell, then differentiated into a neuron.

13 Mar 2025

Developing heart cells use "speed dating" to find the right match

In developing hearts, cells shuffle around, bumping into each other to find their place, and the stakes are high: pairing with the wrong cell could mean the difference between a beating heart and one that falters.

12 Mar 2025

Novel regulators in digestive tract disease progression and treatment

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive tract diseases, positioning these molecules as potential biomarkers for diagnosis, prognosis, and targeted therapies. The comprehensive review explores the biogenesis, classification, and biological functions of tsRNAs, shedding light on their influence over cellular processes such as translation regulation, epigenetic modification, and protein interactions.

11 Mar 2025

Decoding programmed cell death in breast cancer

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC remains a significant global health challenge.

11 Mar 2025

Study highlights the role of ELF4 as a key transcription factor in development, immunity, and oncology

ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published review underscores its molecular complexity and clinical significance, shedding light on its dual role in tumor suppression and oncogenesis.

11 Mar 2025

Deciphering the tumor-immune interplay in endometrial carcinoma

A new review article published in Genes & Diseases sheds light on the complex molecular mechanisms through which tumor-infiltrating immune cells regulate endometrial carcinoma (EC). As one of the most prevalent gynecological cancers, EC continues to challenge researchers and clinicians due to its dynamic interaction with the immune microenvironment.

11 Mar 2025

Study reveals TCM-Based strategies for ferroptosis modulation

Innovative insights into the role of ferroptosis, a unique form of programmed cell death, are reshaping the landscape of disease treatment. This growing field highlights how Traditional Chinese Medicine (TCM) can effectively modulate ferroptosis, offering novel therapeutic approaches for various conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and organ injuries.

11 Mar 2025

Scientists discover key molecular switch for blood stem cell regeneration

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study led by Weill Cornell Medicine investigators.

10 Mar 2025