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New trial aims to make rectal cancer more responsive to radiation

City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, has opened a phase 1 trial seeking to one day transform rectal cancer from a mostly radiation-resistant disease to one that can be cured using radiation and chemotherapy.

25 Mar 2025

Besifovir dipivoxil maleate offers comparable efficacy and improved safety for hepatitis B patients

Hepatitis B is a liver infection cause by the hepatitis B virus (HBV), and long-term hepatitis B infections that last longer than six months are considered "chronic".

24 Mar 2025

£2.2 million grant supports clinical trials for liver dialysis device

Clinical trials to continue the development of a liver dialysis device to treat those with life-threatening liver disease have been funded by a grant awarded to UCL, the Royal Free Hospital and Yaqrit.

21 Mar 2025

New targeted therapy shows early success in treating pediatric high-grade gliomas

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric and young patients with a form of high-grade glioma.

20 Mar 2025

Experimental drug shows promise in reducing risk of Alzheimer's-related dementia

An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a study led by the Knight Family Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), which is based at Washington University School of Medicine in St. Louis.

19 Mar 2025

Clinical trial investigates osteoporosis medication for type 1 diabetes

City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States and a top research center for diabetes and other life-threatening illnesses, is leading a phase 1/2 clinical trial investigating an osteoporosis medication as a way to improve beta cell health in people with early type 1 diabetes.

19 Mar 2025

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

A large-scale, international, multicentre, phase 3 clinical trial of aspirin for the secondary prevention of colorectal cancer has concluded.

17 Mar 2025

Clinical trial of vaccine candidate to prevent Lassa fever begins enrollment

A National Institutes of Health (NIH)-sponsored clinical trial of a candidate vaccine to prevent Lassa fever has begun enrolling participants at the University of Maryland School of Medicine, Baltimore.

17 Mar 2025

Adding chemotherapy to radiotherapy does not improve outcomes for cervical cancer patients

Results from the NRG Oncology GOG-0263 phase III clinical trial testing the addition of cisplatin-based chemotherapy to adjuvant radiotherapy following radical hysterectomy and lymphadenectomy for patients with early-stage, intermediate-risk cervical carcinoma indicated that the addition of chemotherapy did not improve outcomes for patients and led to increased toxicity for patients.

14 Mar 2025

Groundbreaking stem cell therapy trial for Alzheimer's disease underway at UTHealth Houston

A stem cell therapy trial aimed at reducing neuroinflammation in patients with presymptomatic Alzheimer's disease is underway at UTHealth Houston.

14 Mar 2025

Clinical trial tests herpes virus-based therapy for neurogenic bladder in people with spinal cord injury

A modified herpes virus that targets spinal cord nerve cells to treat neurogenic bladder in people with spinal cord injury is underway in a first-in-human clinical trial by UTHealth Houston at TIRR Memorial Hermann.

12 Mar 2025

Oral antiviral drug proves successful in preventing symptomatic COVID-19 in household members

An international clinical trial has identified a medication that can help prevent symptomatic COVID-19 in people exposed within households.

12 Mar 2025

Tecovirimat monotherapy found ineffective for treating clade II mpox in NIH-sponsored trial

NIH-sponsored trial data offer further evidence to help inform mpox treatment decisions.

12 Mar 2025

Tirzepatide helps people without diabetes lose 13% body weight in real-world study

A real-world study of over 4,000 US patients without type 2 diabetes found that those who persisted with Tirzepatide for at least six months lost an average of 12.9% of their body weight. The study highlights Tirzepatide’s potential as an effective off-label obesity treatment before its formal FDA approval for weight loss.

11 Mar 2025

Next-generation, inhaled COVID-19 vaccine enters phase-2 clinical trial

Researchers at McMaster University have started a phase-2 clinical trial on a next-generation, inhaled COVID-19 vaccine.

10 Mar 2025

Eradivir begins Phase 2 challenge study for antiviral therapeutic EV25

Eradivir, a clinical-stage small molecule immunotherapy biotech company, announced it has begun a Phase 2 challenge study with its antiviral therapeutic, EV25. The study will provide safety and efficacy data gathered from otherwise healthy participants infected with influenza then later treated with EV25.

7 Mar 2025

Breakthrough drug more than doubles survival in glioblastoma patients

A drug developed at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has been shown to extend survival for patients with glioblastoma, the most common primary brain tumor in adults.

7 Mar 2025

Phase 1 trial examines safety and feasibility of stem cell treatment for Parkinson's

A recently launched Phase 1 clinical trial at Mass General Brigham is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson's disease in which a patient's stem cells are reprogrammed to replace dopamine cells in the brain damaged by the disease.

6 Mar 2025

New clinical trial aims to optimize pain management and reduce opioid use after mastectomy

A multidisciplinary team of University of Cincinnati Cancer Center researchers is leading a new clinical trial aimed to optimize pain management and reduce the need for opioids after mastectomy procedures.

6 Mar 2025

Stem cell therapy for cornea injuries demonstrates remarkable results in clinical trial

An expanded clinical trial that tested a groundbreaking, experimental stem cell treatment for blinding cornea injuries found the treatment was feasible and safe in 14 patients who were treated and followed for 18 months, and there was a high proportion of complete or partial success.

4 Mar 2025

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Drug Trial News

New trial aims to make rectal cancer more responsive to radiation

Besifovir dipivoxil maleate offers comparable efficacy and improved safety for hepatitis B patients

£2.2 million grant supports clinical trials for liver dialysis device

New targeted therapy shows early success in treating pediatric high-grade gliomas

Experimental drug shows promise in reducing risk of Alzheimer's-related dementia

Clinical trial investigates osteoporosis medication for type 1 diabetes

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

Clinical trial of vaccine candidate to prevent Lassa fever begins enrollment

Adding chemotherapy to radiotherapy does not improve outcomes for cervical cancer patients

Groundbreaking stem cell therapy trial for Alzheimer's disease underway at UTHealth Houston

Clinical trial tests herpes virus-based therapy for neurogenic bladder in people with spinal cord injury

Oral antiviral drug proves successful in preventing symptomatic COVID-19 in household members

Tecovirimat monotherapy found ineffective for treating clade II mpox in NIH-sponsored trial

Tirzepatide helps people without diabetes lose 13% body weight in real-world study

Next-generation, inhaled COVID-19 vaccine enters phase-2 clinical trial

Eradivir begins Phase 2 challenge study for antiviral therapeutic EV25

Breakthrough drug more than doubles survival in glioblastoma patients

Phase 1 trial examines safety and feasibility of stem cell treatment for Parkinson's

New clinical trial aims to optimize pain management and reduce opioid use after mastectomy

Stem cell therapy for cornea injuries demonstrates remarkable results in clinical trial

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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