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Levonorgestrel-piroxicam co-treatment shows promise as more effective emergency contraception

Taking piroxicam, an anti-inflammatory medication commonly used for arthritis pain, at the same time as the levonorgestrel emergency contraceptive pill after unprotected sex prevents significantly more pregnancies compared to taking levonorgestrel alone, according to a randomised controlled trial published in The Lancet.

17 Aug 2023

Insilico Medicine's new AI tool shows promise in predicting clinical trial outcomes

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has demonstrated that it can predict the outcome of Phase II to Phase III clinical trial success using its proprietary transformer-based AI clinical trial prediction tool called inClinico with a high degree of accuracy.

3 Aug 2023

Kombucha may help lower blood sugar levels in people with type 2 diabetes

People with type-II diabetes who drank the fermented tea drink kombucha for four weeks had lower fasting blood glucose levels compared to when they consumed a similar-tasting placebo beverage, according to results from a clinical trial conducted by researchers at Georgetown University's School of Health, the University of Nebraska-Lincoln and MedStar Health.

1 Aug 2023

NIH launches and opens enrollment for phase 2 clinical trials to evaluate long COVID treatments

Today, the National Institutes of Health launched and is opening enrollment for phase 2 clinical trials that will evaluate at least four potential treatments for long COVID, with additional clinical trials to test at least seven more treatments expected in the coming months.

31 Jul 2023

Trial evaluates purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

Researchers investigated the safety and pharmacokinetics of JNJ-54175446 in a double-blind, multicenter, randomized controlled trial (RCT).

31 Jul 2023

New class of antibody could benefit patients with treatment-resistant cancers

A Cancer Research UK-funded clinical trial has shown, for the first time, that a new class of antibody could benefit cancer patients whose existing treatments have stopped working.

28 Jul 2023

Broad-spectrum influenza vaccine candidate shows safety, immunogenicity data across three dose levels

Osivax, a biopharmaceutical company developing vaccines to provide broad-spectrum protection against highly mutating infectious viruses, today announced that The Lancet Infectious Diseases published results from the company's OVX836-003 study under the title, "Immunogenicity, safety and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate: randomized, double-blind placebo-controlled, Phase 2a trial."

27 Jul 2023

Exclusion of chronic kidney disease patients from cardiovascular trials leaves significant evidence gaps

Study looks at how and where patients with CKD have been excluded from CVD RCTs over the last two decades.

24 Jul 2023

ECOG-ACRIN launches new trial to evaluate nilotinib and paclitaxel for advanced cancers

The ECOG-ACRIN Cancer Research Group has enrolled the first patient in a new treatment trial to evaluate the effectiveness of adding nilotinib to standard paclitaxel chemotherapy.

20 Jul 2023

New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Researchers reported on Nurr1 as a promising therapeutic target for managing Parkinson's disease (PD).

20 Jul 2023

Donanemab: A trailblazer for Alzheimer's disease treatment?

A recent study evaluated the efficacy and side effects of donanemab, an antibody that could possibly clear brain amyloid plaque in early symptomatic Alzheimer disease (AD).

20 Jul 2023

Donanemab may offer new hope for people with early Alzheimer's disease

The data reported today by Eli Lilly from the TRAILBLAZER-ALZ 2 clinical trial of donanemab in early symptomatic Alzheimer's disease demonstrate an important advancement in Alzheimer's research and treatment.

17 Jul 2023

PALACE study: Direct oral challenge can safely remove penicillin allergy label

Penicillin allergy affects more than 25 million people in the United States (up to 1 in 10 Americans) and has been shown to lead to particularly poor health outcomes in pregnant women and surgical patients. It is also a public health threat, leading to antibiotic resistance and infections in hospitalized patients that can be life threatening.

17 Jul 2023

Donanemab shows promise in slowing Alzheimer's disease

With yet a third new Alzheimer's drug expected to be approved by the Food and Drug Administration (FDA), the field is beginning to show progress in the fight to slow the disease.

17 Jul 2023

Exploring the efficacy of topical lidocaine in individuals with chronic neck pain

A team of researchers investigated the efficacy of lidocaine for the treatment of neck pain.

17 Jul 2023

NIH funding for phased clinical trials represents <3.5% of total spending

The U.S. National Institutes of Health (NIH) contributed $8.1 billion in project funding for phased clinical trials involving drugs approved by the FDA from 2010-2019, according to a new study from Bentley University's Center for Integration of Science and Industry.

14 Jul 2023

Pembrolizumab combination therapies effective for advanced NSCLC, study shows

While pembrolizumab is an approved treatment for patients with stage III non-small cell lung cancer (NSCLC), only some patients respond to this therapy. Treatment failure, researchers say, is often caused by differences in the tumor microenvironment.

12 Jul 2023

Cytisinicline could offer adult cigarette smokers a potential new treatment option

The first large-scale U.S. clinical trial of cytisinicline, led by a Massachusetts General Hospital (MGH) investigator, found the smoking cessation medication to be effective and well tolerated in adults who wished to break their nicotine dependence.

11 Jul 2023

New clinical trial seeks a regenerative pharmaceutical solution for meniscal tears

With support from Amplicore, a University of Cincinnati spinoff biopharmaceutical company, researchers at UC have begun a Department of Defense-funded clinical trial that seeks a regenerative pharmaceutical solution for meniscal tears.

10 Jul 2023

Two anti-inflammatory drugs reduce deaths in severe COVID-19 patients

Two anti-inflammatory drugs, abatacept and infliximab, reduced deaths among patients hospitalized with severe COVID-19, according to a national study led by Washington University School of Medicine in St. Louis. William G. Powderly, MD, (right) who led the large clinical trial, discusses patient conditions with Maanasi Samant, MD, in the intensive care unit at Barnes-Jewish Hospital, one of the major trial sites, during the COVID-19 pandemic.

10 Jul 2023

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Drug Trial News

Levonorgestrel-piroxicam co-treatment shows promise as more effective emergency contraception

Insilico Medicine's new AI tool shows promise in predicting clinical trial outcomes

Kombucha may help lower blood sugar levels in people with type 2 diabetes

NIH launches and opens enrollment for phase 2 clinical trials to evaluate long COVID treatments

Trial evaluates purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

New class of antibody could benefit patients with treatment-resistant cancers

Broad-spectrum influenza vaccine candidate shows safety, immunogenicity data across three dose levels

Exclusion of chronic kidney disease patients from cardiovascular trials leaves significant evidence gaps

ECOG-ACRIN launches new trial to evaluate nilotinib and paclitaxel for advanced cancers

New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Donanemab: A trailblazer for Alzheimer's disease treatment?

Donanemab may offer new hope for people with early Alzheimer's disease

PALACE study: Direct oral challenge can safely remove penicillin allergy label

Donanemab shows promise in slowing Alzheimer's disease

Exploring the efficacy of topical lidocaine in individuals with chronic neck pain

NIH funding for phased clinical trials represents <3.5% of total spending

Pembrolizumab combination therapies effective for advanced NSCLC, study shows

Cytisinicline could offer adult cigarette smokers a potential new treatment option

New clinical trial seeks a regenerative pharmaceutical solution for meniscal tears

Two anti-inflammatory drugs reduce deaths in severe COVID-19 patients

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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