Genomics

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Breast Cancer as a Dynamic Disease

An interview with Dr. Andrew Ewald, discussing the influence of the myoepithelium on breast cancer growth and the importance of studying metastasis.

19 Oct 2018

Gene sequencing reveals crucial molecular aspects of Trypanosoma brucei

Trypanosoma brucei, which causes sleeping sickness, evades the immune system by repeatedly altering the structure of its surface coat. Sequencing of its genome and studies of its 3D genome architecture have now revealed crucial molecular aspects of this strategy.

19 Oct 2018

Father’s exposure to nicotine may cause cognitive deficits in descendants

A father’s exposure to nicotine may cause cognitive deficits in his children and even grandchildren, according to a study in mice publishing on October 16 in the open-access journal PLOS Biology by Pradeep Bhide of Florida State University in Tallahassee and colleagues.

19 Oct 2018

Genetically modifying zebrafish provides numerous, highly accurate disease models

Research published today describes how zebrafish can be genetically engineered to produce more accurate models of human disease.

18 Oct 2018

Researchers demonstrate epigenetic memory transmission via sperm

A new study suggests that if the epigenetics of sperm chromosomes are altered by the environment a father experiences, then this could affect offspring’s health.

17 Oct 2018

New findings reveal potential cellular players in tumor microenvironment

New findings presented today by CytoReason reveals possible new cellular players in the tumor microenvironment that could impact the treatment process for the most in-need patients - those who have already failed to respond to ipilimumab (anti-CTLA4) immunotherapy.

16 Oct 2018

Researchers sequence two selfish genes in the fungus Neurospora intermedia

Selfish genes are genes that are passed on to the next generation but confer no advantage on the individual as a whole, and may sometimes be harmful.

15 Oct 2018

Researchers to study the use of CRISPR on human liver on-a-chip platform

Two Arizona State University professors are among the first recipients of Somatic Cell Genome Editing grants from the National Institutes of Health Common Fund. The $2,600,000, five-year grant will fund the first study of the genome editing technology CRISPR to be used on a "human liver on-a-chip" platform.

15 Oct 2018

Scientists use haploid stem cells to produce mice with same-sex parents

In a new study, Chinese researchers were able to produce healthy mouse pups with two mothers. The research involved the use of haploid embryonic stem cells.

12 Oct 2018

Metabolome tests could be new way to measure obesity and health

The link between obesity and health problems may seem apparent. People who are obese are at higher risk of type 2 diabetes, liver disease, cancer, and heart disease.

12 Oct 2018

Researchers develop organoid that functions as real salivary gland

Researchers have successfully used induced pluripotent stem cells to grow a 3D salivary gland tissue that produces saliva when implanted in mice.

11 Oct 2018

DNA vaccine shown to provide long-term protection from Ebola

A synthetic DNA vaccine has been shown to provide complete and enduring protection from Ebola virus in preclinical studies.

11 Oct 2018

Research team awarded $3.6 million to assess safety of genome editing

As genome editing technologies quickly advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. They are also bringing to light a number of challenges that need to be addressed before potential treatments can be widely used in patients.

11 Oct 2018

Molecular pathways underlying myopia open new ways for drug development

Myopia (nearsightedness) and hyperopia (farsightedness) develop through different molecular pathways, according to a new study publishing October 9 in the open-access journal PLOS Biology by Andrei Tkatchenko of Columbia University and colleagues.

10 Oct 2018

Scientists identify new biomarker for Alzheimer's disease of sporadic origin

The objective of the research, undertaken in the laboratories of the IBPM, is to develop a model for studying Alzheimer's disease of sporadic origin, in other words, not due to a hereditary genetic mutation.

10 Oct 2018

Scientists discover pheromone-sensing gene that predates land-dwelling vertebrates

Scientists at Tokyo Institute of Technology have discovered a gene that appears to play a vital role in pheromone sensing. The gene is conserved across fish and mammals and over 400 million years of vertebrate evolution, indicating that the pheromone sensing system is much more ancient than previously believed.

10 Oct 2018

Massively parallel single-nucleus RNA sequencing reveals insights into heart disease

Scientists using a powerful new technology that sequences RNA in 20,000 individual cell nuclei have uncovered new insights into biological events in heart disease.

9 Oct 2018

Researchers provide new knowledge about retrovirus-host coevolution

Retroviruses have colonized vertebrate hosts for millions of years by inserting their genes into host genomes, enabling their inheritance through generations as endogenous retroviruses.

8 Oct 2018

Researchers design new method to pinpoint genetic differences between species

Why do naked mole rats live up to 31 years, when distantly related lab mice are lucky to make it to four? How is the aquatic axolotl capable of regenerating limbs, jaws, spines and even brains when frogs can only regrow tails as tadpoles? How can these difference be exploited for the benefit of human health?

8 Oct 2018