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Publication validates company's structure-based approach for addressing undruggable targets

Emerald BioStructures (formerly deCODE biostructures) announced today a publication in the December 27, 2009 advance online issue of Nature Biotechnology, detailing the application of structure-based drug design (SBDD) to engineer new allosteric small molecule modulators of the enzyme phosphodiesterase-4 (PDE4), with reduced side effects.

28 Dec 2009

Study suggests Fanconi Anemia and Bloom's Syndrome proteins may act in common DNA repair pathway

A new study establishes a molecular link that bridges two rare inherited disorders and explains why these diseases result in genetic instability. The research, published by Cell Press in the December 24th issue of the journal Molecular Cell, may lead to a better understanding of the complex mechanisms that enable cells to repair damaged DNA.

28 Dec 2009

Test tube experiments show slight changes in protein chemistry can eliminate Huntington's disease in mice

In Huntington's disease, a mutated protein in the body becomes toxic to brain cells. Recent studies have demonstrated that a small region adjacent to the mutated segment plays a major role in the toxicity. Two new studies supported by the National Institutes of Health show that very slight changes to this region can eliminate signs of Huntington's disease in mice.

28 Dec 2009

Discovery of beta cell defending enzyme raises hope for new treatments against diabetes

Cells in your body are constantly churning out poisonous forms of oxygen (oxidants) and mopping them up with a countervailing force of proteins and chemicals (anti-oxidants).

28 Dec 2009

Findings may shed light on the origins of autism and attention deficit disorders

Like a spotlight that illuminates an otherwise dark scene, attention brings to mind specific details of our environment while shutting others out. A new study by researchers at the Salk Institute for Biological Studies shows that the superior colliculus, a brain structure that primarily had been known for its role in the control of eye and head movements, is crucial for moving the mind's spotlight.

28 Dec 2009

Steroids not superior to laser treatments for DME

Researchers led by specialists at the Johns Hopkins Wilmer Eye Institute have found that injecting a corticosteroid, triamcinolone, directly into the eye may slow the progression of proliferative diabetic retinopathy, a complication of diabetes that frequently leads to blindness.

27 Dec 2009

Discovery of protein transport promotes new research on spinal defects

Spinal cord disorders like spina bifida arise during early development when future spinal cord cells growing in a flat layer fail to roll up into a tube. In the Dec. 6 issue of Nature Cell Biology, researchers from the Johns Hopkins University School of Medicine team with colleagues at the University of California, Berkeley to report a never-before known link between protein transport and mouse spinal cord development, a discovery that opens new doors for research on all spinal defects.

27 Dec 2009

Self-seeding process of cancer cells can enhance tumor growth, says study

Cancer progression is commonly thought of as a process involving the growth of a primary tumor followed by metastasis, in which cancer cells leave the primary tumor and spread to distant organs.

27 Dec 2009

Highlights from Mayo Clinic's Discovery's Edge research magazine

Here are highlights from the winter issue of Discovery's Edge, Mayo Clinic's research magazine.

24 Dec 2009

American Diabetes Association lauds passage of health reform in the Senate

The American Diabetes Association issues the following statement about the passing of HR 3590 The Patient Protection and Affordable Care Act.

24 Dec 2009

New book on caries management

The International Caries Detection and Assessment System (ICDAS) offers clinical criteria and codes, together with a framework to support and enable personalized comprehensive caries management for improved long-term health outcome. Based on the ICDAS, this publication provides an up-to-date synthesis of the fields of detection, assessment, diagnosis and monitoring of caries.

24 Dec 2009

Peritoneal dialysis updates

The importance of peritoneal dialysis (PD) in the therapy of chronic kidney disease has been steadily increasing. The simultaneous advancement in clinical practice and basic research has increased overall knowledge and led to significant progress in the safe and adequate application of PD. Moreover, integration with other techniques in the therapy of uremia represents an important step in the optimization of the whole program of renal replacement therapy.

24 Dec 2009

UCB's Cimzia gains market share of Centocor's Simponi

BioTrends Research Group, Inc. announces the release of the final wave of LaunchTrends®: Simponi and Cimzia report. The survey was completed by U.S. Rheumatologists.

24 Dec 2009

E2F1 transcription factor inhibition reduces EGFR expression and invasive potential of melanoma cells

Inhibition of transcription factor E2F1 reduced epidermal growth factor receptor (EGFR) expression and reduced the invasive potential but not proliferation of metastatic melanoma cells, according to a brief communication published online December 23 in the Journal of the National Cancer Institute.

24 Dec 2009

Eli Lilly and Kowa Pharmaceuticals America to co-promote LIVALO in the U.S

Eli Lilly and Company (NYSE: LLY), Kowa Company, Limited, and Kowa's U.S. subsidiary, Kowa Pharmaceuticals America, Inc., today announced that Lilly and Kowa Pharmaceuticals America have entered into a co-promotion agreement in the United States to commercialize LIVALO® (pitavastatin). Lilly and Kowa have also entered into a licensing agreement in Latin America. LIVALO is a statin approved by the U.S. Food and Drug Administration (FDA) in August 2009 for the treatment of primary hyperlipidemia and mixed dyslipidemia.

24 Dec 2009

Study suggests routine evaluation does not predict prostate cancer

On the heels of the American Cancer Society's recent controversial response to breast and prostate cancer screenings guidelines, a new study from the Mayo Clinic has emerged analyzing the correlation between prostate-specific antigen (PSA) levels and prostate size. The study discovered that routine annual evaluation of prostate growth does not predict the development of prostate cancer.

24 Dec 2009

Key molecular switch linked to HD identified

Scientists have identified a key molecular switch that may drive the onset of Huntington's disease (HD), an incurable neurodegenerative disorder that leads to severe disruptions in muscle coordination and cognitive function. The research, published by Cell Press in the December 24 issue of the journal Neuron, enhances the understanding of HD pathogenesis and may direct new strategies for treating this devastating brain disease.

24 Dec 2009

Potential new therapeutic option for prevention of PD-associated neuropathology

Scientists have identified a synergistic interaction that disrupts normal intracellular transport mechanisms and leads to the accumulation of neuron-damaging clumps of protein associated with Parkinson's disease (PD), a neurodegenerative disorder that is characterized by a specific loss of neurons in the midbrain and brainstem. The research, published by Cell Press in the December 24 issue of the journal Neuron, identifies a new potential therapeutic option for preventing PD-associated neuropathology.

24 Dec 2009

Tips to minimize injuries during winter season

As we try to get outside and make the most of these cold winter months, it's important to use basic safety tips that help minimize injury. The Minnesota Chiropractic Association (MCA) offers the following tips to help keep your family injury free.

24 Dec 2009

Study evaluates anemia treatment approaches adopted by different specialists

BioTrends Research Group, Inc. published a syndicated research report, "TreatmentTrends®: Anemia in the United States," based on primary research conducted with approximately 400 physicians in clinical practice.

24 Dec 2009

Medical Condition News

Publication validates company's structure-based approach for addressing undruggable targets

Study suggests Fanconi Anemia and Bloom's Syndrome proteins may act in common DNA repair pathway

Test tube experiments show slight changes in protein chemistry can eliminate Huntington's disease in mice

Discovery of beta cell defending enzyme raises hope for new treatments against diabetes

Findings may shed light on the origins of autism and attention deficit disorders

Steroids not superior to laser treatments for DME

Discovery of protein transport promotes new research on spinal defects

Self-seeding process of cancer cells can enhance tumor growth, says study

Highlights from Mayo Clinic's Discovery's Edge research magazine

American Diabetes Association lauds passage of health reform in the Senate

New book on caries management

Peritoneal dialysis updates

UCB's Cimzia gains market share of Centocor's Simponi

E2F1 transcription factor inhibition reduces EGFR expression and invasive potential of melanoma cells

Eli Lilly and Kowa Pharmaceuticals America to co-promote LIVALO in the U.S

Study suggests routine evaluation does not predict prostate cancer

Key molecular switch linked to HD identified

Potential new therapeutic option for prevention of PD-associated neuropathology

Tips to minimize injuries during winter season

Study evaluates anemia treatment approaches adopted by different specialists

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

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