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New insights into pathogenic T cells offer hope for Crohn's disease treatment

The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.

4 Sep 2025

Neuritin 1 unlocks new pathway to treat obesity without reducing food intake

Is it possible to treat obesity without reducing food intake? A new study co-led by Dr. Antonio Zorzano and Dr. Manuela Sánchez-Feutrie at the Institute for Research in Biomedicine (IRB Barcelona) suggests that this might be a possibility, at least in animal models.

4 Sep 2025

Unraveling adult ADHD symptoms through genetics and data science

Kelli Lehto, Associate Professor of Neuropsychiatric Genomics at the University of Tartu, is leading a prestigious European Research Council (ERC) grant project that brings together genetics, psychology, and data science to investigate the causes of attention deficit hyperactivity disorder (ADHD) in adults and enhance diagnostic methods.

4 Sep 2025

As insurers struggle with GLP-1 drug costs, some seek to wean patients off

After losing 50 pounds on the injectable weight loss medication Zepbound, Kyra Wensley received a surprising letter from her pharmacy benefit manager in April.

4 Sep 2025

Smell loss emerges as the early behavioural sign of Alzheimer’s

Research reveals immune cells target brainstem nerves, linking smell loss to early Alzheimer's, offering potential for earlier diagnosis and intervention.

4 Sep 2025

Daily probiotic reduces pouchitis risk after colon removal surgery but may not be cost-effective

A new UCLA Health study found that taking an 8-strain probiotic daily may reduce the risk of pouchitis, a common inflammatory condition that occurs after colon removal surgery for ulcerative colitis, but the treatment may not be worth the cost depending on a patient's likelihood of flare-ups.

3 Sep 2025

UCLA Health receives NIH grant to expand innovative chronic pain therapy for veterans

UCLA Health has received a $7.1 million grant from the National Institutes of Health to expand research into a newer form of psychotherapy that has been shown to more significantly alleviate chronic pain among older adults compared to traditional cognitive behavioral therapy.

3 Sep 2025

Living in food deserts linked to higher stroke and death risk in atrial fibrillation patients

Patients with atrial fibrillation who live in neighborhoods with poor access to full-service grocery stores face sharply higher odds of stroke and death, according to a new study from Tulane University.

3 Sep 2025

Colorectal cancer identified by its unique microbial fingerprint

Colorectal cancer is unique in having its own microbial 'fingerprint' – according to new research from the University of East Anglia.

3 Sep 2025

Trial compares the use of blood thinners after stenting in patients with acute coronary syndromes

Noninferiority was not demonstrated for death and ischemic events between P2Y12 inhibitor monotherapy and dual antiplatelet therapy (DAPT) given for 12 months after stenting in patients with acute coronary syndromes (ACS), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

3 Sep 2025

Impaired spatial orientation found in older adults at risk for Alzheimer’s disease

Individuals with an increased risk for dementia due to Alzheimer's disease can have impaired spatial orientation skills.

3 Sep 2025

Dual antiplatelet therapy shows no benefit over aspirin after CABG in patients with acute coronary syndrome

Dual antiplatelet therapy (DAPT) was not more effective than aspirin alone for the prevention of major adverse cardiovascular events and increased major bleeding in patients with acute coronary syndrome (ACS) who underwent coronary artery bypass grafting (CABG), according to late-breaking research presented in a Hot Line session today at ESC Congress 20251 and simultaneously published in New England Journal of Medicine.

3 Sep 2025

Stopping oral anticoagulation reduces risk after successful atrial fibrillation ablation

Discontinuing oral anticoagulation (OAC) therapy resulted in a lower risk of a composite of stroke, systemic embolism or major bleeding than continuing OAC therapy in patients who had successful ablation for atrial fibrillation at least 12 months previously, according to results from a late-breaking trial presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in The Journal of the American Medical Association.

3 Sep 2025

Reconditioned pacemakers show comparable infection rates to new devices

Procedure-related infection rates were similar with reconditioned and new pacemakers, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

3 Sep 2025

Sacubitril/valsartan shows benefit over enalapril in heart failure caused by Chagas disease

In patients with heart failure (HF) caused by Chagas disease, sacubitril/valsartan was superior to enalapril for the composite primary endpoint, predominantly driven by a significant reduction in N-terminal pro-B-type natriuretic peptide (NT-proBNP), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

3 Sep 2025

Evolocumab fails to reduce vein graft disease after coronary artery bypass surgery

After coronary artery bypass grafting (CABG), evolocumab did not reduce saphenous vein graft disease rates at 2 years compared with placebo, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in Lancet.

3 Sep 2025

No clear benefit from surgical left atrial appendage occlusion in non-AF patients after valve surgery

No benefit in terms of prevention of ischemic stroke, transient ischemic attack and cardiovascular mortality after 1 year was observed when surgical left atrial appendage occlusion was performed in high-risk non-atrial fibrillation patients after valvular surgery, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

3 Sep 2025

Study finds sex differences in schizophrenia and bipolar disorder

Schizophrenia and bipolar disorder are serious mental illnesses that affect both males and females, but research in Acta Psychiatrica Scandinavica indicates that sex may influence the characteristics and course of these conditions.

3 Sep 2025

Genetic variant disrupts brain’s cleanup crew increasing Alzheimer’s risk

A Nature study published today and led by researchers at the University of South Florida's USF Health Byrd Alzheimer's Institute pinpoints how a genetic variant disrupts microglia - the brain's "cleanup crew" - increasing the risk of Alzheimer's disease.

3 Sep 2025

Long-term benzodiazepine use linked to poor sleep quality in older adults

Long-term use of benzodiazepine and related drugs has been linked to poorer quality sleep in older adults with insomnia.

3 Sep 2025

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Medical Condition News

New insights into pathogenic T cells offer hope for Crohn's disease treatment

Neuritin 1 unlocks new pathway to treat obesity without reducing food intake

Unraveling adult ADHD symptoms through genetics and data science

As insurers struggle with GLP-1 drug costs, some seek to wean patients off

Smell loss emerges as the early behavioural sign of Alzheimer’s

Daily probiotic reduces pouchitis risk after colon removal surgery but may not be cost-effective

UCLA Health receives NIH grant to expand innovative chronic pain therapy for veterans

Living in food deserts linked to higher stroke and death risk in atrial fibrillation patients

Colorectal cancer identified by its unique microbial fingerprint

Trial compares the use of blood thinners after stenting in patients with acute coronary syndromes

Impaired spatial orientation found in older adults at risk for Alzheimer’s disease

Dual antiplatelet therapy shows no benefit over aspirin after CABG in patients with acute coronary syndrome

Stopping oral anticoagulation reduces risk after successful atrial fibrillation ablation

Reconditioned pacemakers show comparable infection rates to new devices

Sacubitril/valsartan shows benefit over enalapril in heart failure caused by Chagas disease

Evolocumab fails to reduce vein graft disease after coronary artery bypass surgery

No clear benefit from surgical left atrial appendage occlusion in non-AF patients after valve surgery

Study finds sex differences in schizophrenia and bipolar disorder

Genetic variant disrupts brain’s cleanup crew increasing Alzheimer’s risk

Long-term benzodiazepine use linked to poor sleep quality in older adults

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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