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Vitamin D curbs colorectal cancer by boosting immunity and blocking tumor growth

Review highlights how vitamin D, particularly its active form calcitriol, modulates immune responses, inflammation, and tumor progression to help prevent colorectal cancer (CRC). Evidence suggests adequate vitamin D levels and supplementation reduce CRC risk and improve outcomes.

21 Apr 2025

Gut microbiome pattern predicts future heart attack risk in coronary heart disease patients

A specific gut microbiota pattern was found to predict new cardiovascular events in patients with coronary heart disease, based on data from the CORDIOPREV study. Researchers developed a microbiota-based risk score that may improve secondary prevention.

21 Apr 2025

Diabetes drugs GLP-1RA and SGLT2i lower dementia risk in older adults, study finds

A large population-based study found that GLP-1 receptor agonists (GLP-1RAs) and SGLT2 inhibitors (SGLT2is), two classes of glucose-lowering drugs used in type 2 diabetes, were associated with a significantly reduced risk of Alzheimer’s disease and related dementias (ADRD). These findings suggest potential neuroprotective benefits and highlight drug repurposing as a promising strategy for ADRD prevention.

21 Apr 2025

Anxiety and depression in children increased steadily from 2016 to 2022

The percentage of children under 18 years old with anxiety and depression increased steadily from 2016 to 2022, according to publicly available data from the National Survey of Children's Health that were analyzed by researchers from Ann & Robert H. Lurie Children's Hospital of Chicago.

21 Apr 2025

Ursolic acid modulates estrogen conversion to alleviate MASLD inflammation

The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been escalating annually, positioning it as the leading cause of chronic liver disease worldwide.

21 Apr 2025

Hospitals can play key role in treating alcohol use disorder

Nearly 30 million adults in the United States experience alcohol use disorder (AUD), but the vast majority of people with this condition do not receive treatment.

21 Apr 2025

Study reveals a molecular connection between autism and myotonic dystrophy

A recent discovery of a molecular connection between autism and myotonic dystrophy, a type of neuromuscular disease, may provide a breakthrough on how clinicians approach autism spectrum disorder.

21 Apr 2025

One in five boys and men may have an eating disorder

A new study has found that over 1 in 5 boys and men in Canada and the United States may meet the diagnostic criteria for an eating disorder, highlighting the urgent need for greater awareness, tailored prevention efforts, and inclusive clinical support for this under-recognized group.

21 Apr 2025

Cancer immunotherapy effective across all ages despite immune differences

Older adults with cancer respond just as well as younger patients to immune checkpoint inhibitors despite age-related immune system differences, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy, and the Johns Hopkins Convergence Institute.

21 Apr 2025

Differentiating cancerous and healthy cells through motion analysis

Researchers from Tokyo Metropolitan University have found that the motion of unlabeled cells can be used to tell whether they are cancerous or healthy.

20 Apr 2025

New therapeutic frontiers in the management of achondroplasia

A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular mechanisms and therapeutic interventions for achondroplasia, the most common form of genetic dwarfism.

20 Apr 2025

Molecular drivers and emerging treatments in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge.

20 Apr 2025

GOT2 as a metabolic and immunologic target in pancreatic cancer

A new wave of scientific interest is spotlighting GOT2—glutamic-oxaloacetic transaminase 2—as a compelling therapeutic target in the fight against pancreatic cancer, one of the most lethal and treatment-resistant malignancies.

20 Apr 2025

Reversing adipose tissue fibrosis through targeted microRNA therapies

A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose tissue fibrosis, a condition closely linked to obesity, diabetes, and cardiovascular disease.

20 Apr 2025

Redefining cardiovascular medicine through the lens of sncRNAs

In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases.

20 Apr 2025

Unmasking Nrf2 as a key driver of treatment resistance in osteosarcoma

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance.

20 Apr 2025

Traditional BMI cut-offs overestimate overweight and obesity in male athletes

New research to be presented at this year's European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) shows that the internationally recognized body mass index (BMI) cut-off points greatly overestimate overweight and obesity in male athletes.

18 Apr 2025

Insurance instability more common among low-income adults with diabetes

An Oregon Health & Science University-led study reveals that low-income adults with diabetes are more likely to go in and out of health insurance, and that insurance instability is even worse for those with complex needs.

18 Apr 2025

Scientists track liquid to solid shift in brain disease proteins

An international research collaboration led by Rutgers University-New Brunswick scientists that examined microscopic blobs of protein found in human cells has discovered that some morph from an almost honey-like substance to a hard candy-like solid.

18 Apr 2025