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Analysis of Alzheimer's disease and related dementias uncovers disparities in Maryland's rural communities

A new statewide spatial analysis of Alzheimer's disease and related dementias (ADRD) has uncovered significant disparities in Maryland's rural communities, offering a striking example of how healthcare accessibility is shaping health outcomes across the United States.

10 Dec 2025

Machine learning models can help diagnose ALS earlier from a blood sample

Using machine learning models, researchers at Michigan Medicine have identified a potential way to diagnose amyotrophic lateral sclerosis, or ALS, earlier from a blood sample, a study suggests.

10 Dec 2025

Triaptosis could be a promising strategy in the fight against cancer

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

10 Dec 2025

Study shines new light on how cancer avoids the mitotic stopwatch pathway

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example DNA damage or chromosomal instability.

10 Dec 2025

Researchers map how brain networks differ in individuals at high clinical risk for psychosis

Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and NHG Health's Institute of Mental Health (IMH) have mapped how brain networks differ in individuals at Clinical High Risk (CHR) for psychosis, providing a new perspective on the mechanisms underlying the disease onset.

10 Dec 2025

$Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma$

Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma

Patients with relapsed or refractory (R/R) multiple myeloma who received a combination of teclistamab, a bispecific monoclonal antibody, and daratumumab, a CD38-directed monoclonal antibody, were 83% more likely to be alive without disease progression compared with those who received standard second-line therapies at a median of nearly 35 months of follow-up, according to the results of a new trial presented at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition.

10 Dec 2025

Pirtobrutinib shows superior outcomes compared to common first-line combination treatment for CLL/SLL

In a new trial, the Bruton tyrosine kinase (BTK) inhibitor pirtobrutinib increased the rate of survival without disease progression and was well tolerated with a more favorable safety profile when compared with bendamustine plus rituximab (BR) in patients with previously untreated chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).

10 Dec 2025

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers profiled a terminally sterilized probiotic-fermented MFH beverage and identified aporphine alkaloids and flavonoids with favorable predicted ADMET properties. Integrated network pharmacology, molecular docking, and 100-ns MD simulations suggest multi-target engagement of metabolic-inflammatory pathways relevant to obesity and type 2 diabetes.

9 Dec 2025

SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection

Middle-ear infections caused by Gram-negative bacteria remain among the most common pediatric illnesses worldwide.

9 Dec 2025

New arts and wellbeing program supports the social needs of families affected by dementia

A new arts and wellbeing program co-developed by the University of South Australia, Flinders University and the University of Adelaide shows that supporting the social needs of people living with dementia and their carers can help families rediscover connection, confidence and a sense of community.

9 Dec 2025

State-funded multidisciplinary model improves care for adults with neurodevelopmental disorders

Adults with autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs) often lose access to specialized care once they age out of pediatric services.

9 Dec 2025

SwRI and Trinity researchers work on next-generation intranasal therapy for PTSD

Southwest Research Institute (SwRI) and Trinity University are developing an intranasal (IN) drug-device combination to treat post-traumatic stress disorder (PTSD).

9 Dec 2025

Doctors warn about cardiovascular dangers from excessive energy drink use

Downing several strong energy drinks every day may pose a serious stroke risk, doctors have warned in the journal BMJ Case Reports, after treating an otherwise fit and healthy man in his 50s with a daily 8-can habit and exceedingly high blood pressure.

9 Dec 2025

Genetic risk score can guide early screening for type 1 diabetes

A test using genetics to predict who is at the highest risk of developing type 1 diabetes could one day be applied to largescale health studies, to identify adults who could benefit from new drugs, new research shows.

9 Dec 2025

AI-driven method uncovers genetic interactions that fuel cancer progression

University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.

9 Dec 2025

Landmark RSI trial reshapes sedative selection for emergency airway management

Doctors treating seriously ill patients in an emergency setting may want to give the sedative etomidate, rather than ketamine, while placing a breathing tube, according to a randomized trial published in the New England Journal of Medicine.

9 Dec 2025

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

People exposed to Agent Orange face higher risk of developing myelodysplastic syndrome

A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to progress to acute myeloid leukemia.

9 Dec 2025

Research ushers in a new era of hope for patients with primary immune thrombocytopenia

More than half of patients in a Phase III clinical trial who received a limited course of the experimental monoclonal antibody ianalumab for primary immune thrombocytopenia (ITP), an autoimmune disorder that can cause life-threatening bleeding, were able to maintain safe platelet counts without serious bleeding episodes for at least one year.

9 Dec 2025

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Medical Condition News

Analysis of Alzheimer's disease and related dementias uncovers disparities in Maryland's rural communities

Machine learning models can help diagnose ALS earlier from a blood sample

Triaptosis could be a promising strategy in the fight against cancer

Study shines new light on how cancer avoids the mitotic stopwatch pathway

Researchers map how brain networks differ in individuals at high clinical risk for psychosis

Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma

Pirtobrutinib shows superior outcomes compared to common first-line combination treatment for CLL/SLL

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection

New arts and wellbeing program supports the social needs of families affected by dementia

State-funded multidisciplinary model improves care for adults with neurodevelopmental disorders

SwRI and Trinity researchers work on next-generation intranasal therapy for PTSD

Doctors warn about cardiovascular dangers from excessive energy drink use

Genetic risk score can guide early screening for type 1 diabetes

AI-driven method uncovers genetic interactions that fuel cancer progression

Landmark RSI trial reshapes sedative selection for emergency airway management

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

People exposed to Agent Orange face higher risk of developing myelodysplastic syndrome

Research ushers in a new era of hope for patients with primary immune thrombocytopenia

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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