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SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

A team of researchers from Aix-Marseille Univ, IHU-Méditerranée Infection, Institut Paoli Calmettes and Laboratoire d’Immunologie, Marseille, France, conducted experiments to determine if SARS-CoV-2 can affect the myeloid compartment or infect monocytes and macrophages.

20 Sep 2020

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Using mouse models, scientists have investigated the active plasma metabolite of remdesivir, GS-441 524, and hydroxychloroquine as possible drug candidates in COVID-19. The research shows GS-441 524 could be an effective therapeutic drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while at the same time discounting hydroxychloroquine as a reliable anti-viral.

20 Sep 2020

Lopinavir-ritonavir does not suppress SARS-CoV-2 activity in vitro

Among them is the combination of lopinavir and ritonavir, which have been in use in an attempt to reduce the severity of the disease. However, a new South Korean study published on the preprint server bioRxiv in September 2020 shows that this combination is ineffective against the virus.

20 Sep 2020

Study identifies new regions of positive selection in SARS-CoV-2

Based on structural modeling of ribonucleic acid (RNA) and proteins, the researchers from Duke University argue that newly identified regions of positive selection in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely affect species-specific RNA instead of protein function – improving our understanding of the molecular mechanisms responsible for highly unique biological properties of this virus.

20 Sep 2020

Researchers try and pop SARS-CoV-2 with an AFM tip - virion surprisingly resilient

Researchers at Semmelweis University and the National Public Health Center in Hungary have conducted an imaging study showing that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for coronavirus disease 2019 (COVID-19), is a highly dynamic and resilient virus

20 Sep 2020

Large mother-child paired study promises more answers on COVID-19 in pregnancy

A new paper published in the preprint server medRxiv* in August 2020 reports the design and preliminary findings of an ongoing study on pregnant mothers and their children born during the pandemic.

20 Sep 2020

Novel sequencing method could be useful for COVID-19 research

Researchers at the University of Chicago and the Cleveland Clinic have presented a novel single-cell RNA sequencing method that could be a useful application for research into the current coronavirus disease 2019 (COVID-19) pandemic.

20 Sep 2020

Evidence-based approaches improve employment outcomes after spinal cord injury

Researchers at Kessler Foundation authored a new article, "Employment after spinal cord injury," (DOI: 10.1007/s40141-020-00266-4), published by Current Physical Medicine and Rehabilitation Reports on May 24, 2020.

19 Sep 2020

New polygenic risk score to help predict the odds of drugs causing liver damage

The ancient Romans studied the livers of sacrificial animals to read omens and make prophesies. Now researchers at Tokyo Medical and Dental University and Takeda-CiRA program along with a world-wide team of collaborators, have devised a polygenic risk score (PRS) based on liver genomics that can predict the likelihood of medications causing liver damage.

19 Sep 2020

U.S. adults experienced increased mental health issues as COVID-19 cases skyrocketed

U.S. adults increasingly experienced symptoms associated with acute stress and depression as COVID-19 cases and deaths skyrocketed between mid-March and mid-April 2020, according to a study of more than 6,500 people from three large, nationally representative cohorts.

19 Sep 2020

New method isolates antibody-like proteins that capture and neutralize SARS-CoV-2

Scientists have used a new high-speed, in vitro selection method to isolate 9 antibody-like proteins (ALPs) that bind to the SARS-CoV-2 virus - 4 of which also exhibited neutralizing activity - within 4 days, according to a new study.

19 Sep 2020

Research identifies new alteration in the brain of people with Alzheimer's

Despite the important advances in research in recent years, the etiopathogenesis of Alzheimer's disease is still not fully clarified. One of the key questions is to decipher why the production of beta amyloid, the protein that produces the toxic effect and triggers the pathology, increases in the brain of people with Alzheimer's.

19 Sep 2020

UB researchers aim to connect the dots on food access

Researchers know from many previous studies what prevents cash-strapped shoppers in underserved communities from buying more fresh produce.

19 Sep 2020

Access to low or no-cost meals disrupted due to school closures during COVID-19

School closures due to the COVID-19 pandemic disrupted access to low or no-cost school breakfast and lunch programs for millions of low-income children.

19 Sep 2020

Rising stress and depressive symptoms linked to pandemic-related losses, media consumption

Experiencing multiple stressors triggered by the COVID-19 pandemic – such as unemployment – and COVID-19-related media consumption are directly linked to rising acute stress and depressive symptoms across the U.S., according to a groundbreaking University of California, Irvine study.

19 Sep 2020

Study examines performance of fabrics for home-made masks against the spread of COVID-19

Studies indicate that homemade masks help combat the spread of viruses like COVID-19 when combined with frequent hand-washing and physical distancing.

19 Sep 2020

$Using AI and fractal dimension to accurately monitor ataxia$

Using AI and fractal dimension to accurately monitor ataxia

Exploiting artificial intelligence (AI) to develop tools for improving the monitoring of treatment of rare, progressive, and highly debilitating diseases such as Friedreich's (FRDA) and spinocerebellar ataxia (SCA).

19 Sep 2020

UConn researchers validate clinical feasibility of CRISPR-based platform for COVID-19 testing

In March, researchers in the Department of Biomedical Engineering-- a shared department in the schools of Dental Medicine, Medicine, and Engineering--began to develop a new, low-cost, CRISPR-based diagnostic platform to detect infectious diseases, including HIV virus, the novel coronavirus (SARS-CoV-2).

19 Sep 2020

Stroke patients with COVID-19 have increased systemic inflammation, higher mortality risk

Stroke patients who also have COVID-19 showed increased systemic inflammation, a more serious stroke severity and a much higher rate of death, compared to stroke patients who did not have COVID-19, according to University of Alabama at Birmingham research led by Chen Lin, M.D., an assistant professor in the UAB Department of Neurology.

19 Sep 2020

Scientists identify new drug to prevent SARS-CoV-2 infection consequences

Scientists from the Department of Cell Biology of the University of Malaga and the Andalusian Centre for Nanomedicine and Biotechnology have made progress in finding new rapid implementation therapies to combat the COVID-19 pandemic, identifying a new drug that could prevent or mitigate the consequences derived from SARS-CoV-2 infection.

19 Sep 2020

Medical Research News

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Lopinavir-ritonavir does not suppress SARS-CoV-2 activity in vitro

Study identifies new regions of positive selection in SARS-CoV-2

Researchers try and pop SARS-CoV-2 with an AFM tip - virion surprisingly resilient

Large mother-child paired study promises more answers on COVID-19 in pregnancy

Novel sequencing method could be useful for COVID-19 research

Evidence-based approaches improve employment outcomes after spinal cord injury

New polygenic risk score to help predict the odds of drugs causing liver damage

U.S. adults experienced increased mental health issues as COVID-19 cases skyrocketed

New method isolates antibody-like proteins that capture and neutralize SARS-CoV-2

Research identifies new alteration in the brain of people with Alzheimer's

UB researchers aim to connect the dots on food access

Access to low or no-cost meals disrupted due to school closures during COVID-19

Rising stress and depressive symptoms linked to pandemic-related losses, media consumption

Study examines performance of fabrics for home-made masks against the spread of COVID-19

Using AI and fractal dimension to accurately monitor ataxia

UConn researchers validate clinical feasibility of CRISPR-based platform for COVID-19 testing

Stroke patients with COVID-19 have increased systemic inflammation, higher mortality risk

Scientists identify new drug to prevent SARS-CoV-2 infection consequences

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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