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Researchers link 9 blood proteins to breast cancer and suggest 3 drugs for repurposing

Researchers used integrated Mendelian randomization in a cohort of over 247,000 individuals to identify 62 plasma proteins associated with breast cancer risk. Nine high-confidence targets, including ULK3 and CSK, showed potential for drug repurposing and immune pathway regulation.

16 Apr 2025

FOXR2 activation found in multiple pediatric brain tumor types

Physicians classify brain tumors and determine treatment options, in part, by the genes they express. According to World Health Organization standards, the abnormal activation of oncogene FOXR2 only occurs in central nervous system (CNS) neuroblastoma, but that may not be true.

16 Apr 2025

Harnessing the healing power of music in clinical care

Rhonda Winegar remembers watching the 2014 documentary "I'll Be Me," which chronicled country music legend Glen Campbell's struggles with Alzheimer's disease.

16 Apr 2025

ChatGPT-4 passes UK medical licensing exam but falters in real-world clinical decision-making, study reveals

ChatGPT-4 was tested on the UK Medical Licensing Assessment and achieved accuracy above most medical students on structured, multiple-choice questions, but struggled more with open-ended, multi-step, and management scenarios. The study highlights both the promise and limitations of AI in real-world medical decision-making and education.

16 Apr 2025

Gold nanoparticles offer new hope for vision restoration

A new study by Brown University researchers suggests that gold nanoparticles - microscopic bits of gold thousands of times thinner than a human hair - might one day be used to help restore vision in people with macular degeneration and other retinal disorders.

16 Apr 2025

Climate change poses global risk to safe blood supply

A new study published in The Lancet Planetary Health suggests a changing climate threatens the continuous availability of safe blood across the world.

16 Apr 2025

Humanized liver organoids double survival rate in rodent models

One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key "zones" that perform specific major tasks.

16 Apr 2025

Study identifies DNA methylation entropy as a biomarker for aging

A new research paper was published in Aging (Aging-US) Volume 17, Issue 3, on March 12, 2025, titled "DNA methylation entropy is a biomarker for aging."

16 Apr 2025

New hope for sclerosteosis patients through Wnt pathway inhibition

Sclerosteosis arises from mutations in the SOST gene, causing abnormally high bone mass and skeletal overgrowth, which can lead to severe health issues such as hearing loss and increased intracranial pressure.

16 Apr 2025

Listening to favorite music activates the brain’s opioid system

A new imaging study by the Turku PET Centre in Finland showed that listening to favorite music affects the function of the brain's opioid system.

16 Apr 2025

Comparing single cell RNA methods to improve gastrointestinal cancer research

Research on gastrointestinal diseases, especially cancer, has mainly looked at the epithelial cells, which line the surfaces of organs, are important for various functions, and are believed to be the cells that go awry to cause these diseases.

16 Apr 2025

Breakthrough method creates functional liver organoids

While organoids aim to mimic human organs, the liver's repertoire of complex functions – and thus the energy it needs to operate – have made it challenging for researchers to grow organoids that proliferate and fully function, says Sato. When prioritizing growth and survival in laboratory settings, hepatocytes, the liver's main cells, eventually transformed into cells resembling cholangiocytes, which line the bile duct.

16 Apr 2025

Breakthrough method allows stem cell treatment for critically ill patients on ECMO

A multidisciplinary clinical team led by Professor Bernat Soria from the Institute of Bioengineering at the Miguel Hernández University of Elche (UMH, Spain) has developed a new method to deliver cell therapies in patients on extracorporeal membrane oxygenation (ECMO), a life support system used in cases of severe lung failure.

16 Apr 2025

Mitochondria found to fuel dangerous growth in aging blood stem cells

As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations.

16 Apr 2025

Study links cold hypersensitivity and heaviness in legs to varicose veins

Hypersensitivity to the cold, especially ice cold feet, as well as a feeling of heaviness in the legs, are linked to the presence of varicose veins, finds a large study published in the open access journal Open Heart.

16 Apr 2025

Study sheds light on brain regions involved in logical thinking

A team of researchers at UCL and UCLH have identified the key brain regions that are essential for logical thinking and problem solving.

16 Apr 2025

Empa scientists create innovative hydrogel for simulating the human skin

Growing cells in the laboratory is an art that humans have mastered decades ago. Recreating entire three-dimensional tissues is much more challenging.

16 Apr 2025

Study identifies brain area linked to social behavior and altruism

Are there areas of the brain, which regulate prosocial, altruistic behaviour? Together with colleagues from the universities in Lausanne, Utrecht and Cape Town, researchers from Heinrich Heine University Düsseldorf (HHU) have studied a very special group of patients and established that the "basolateral amygdala" (part of the limbic system) plays an important role in this.

16 Apr 2025

What sauerkraut can do for your gut

Fermented cabbage metabolites play a crucial role in maintaining gut barrier function, suggesting potential health benefits for inflammatory disorders.

16 Apr 2025

Promising findings for the treatment of patients with pulmonary arterial hypertension with a high risk of mortality

Pulmonary arterial hypertension (PAH) is a rare and severe lung disease with a life-threatening prognosis. After several positive trials, a recent study has confirmed the efficacy of a biotherapy, sotatercept.

16 Apr 2025