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CDC study highlights growing tularemia threat in central U.S.

Tularemia cases in the U.S. rose by 56% from 2011 to 2022, with central states and American Indian communities most affected, highlighting diagnostic advancements and health disparities.

2 Jan 2025

Study provides new insights into the genetic underpinnings of pediatric cancers

Largescale changes in the genome inherited from parents are significant risk factors for pediatric solid tumors, such as Ewing sarcoma, neuroblastoma, and osteosarcoma, according to a new study.

2 Jan 2025

CAR-T cells carry memory of past antigen encounters

Researchers at the University of Colorado Anschutz Medical Campus have discovered that some CAR-T cells engineered to fight cancer and other conditions carry the memory of past encounters with bacteria, viruses and other antigens within them, a finding that may allow scientists to manufacture the cells in more precise and targeted ways.

2 Jan 2025

Breakthrough in immunology: AbMAP’s novel approach to antibody modeling

Researchers developed AbMAP, a cutting-edge framework leveraging transfer learning to model antibody hypervariable regions, significantly improving design and immune repertoire analysis.

2 Jan 2025

Scientists launch public resource to classify cancer subtypes for better diagnosis

A multi-institutional team of scientists has developed a free, publicly accessible resource to aid in classification of patient tumor samples based on distinct molecular features identified by The Cancer Genome Atlas (TCGA) Network.

2 Jan 2025

Insilico Medicine nominates ISM1745 as preclinical candidate for MTAP-deleted cancers

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the nomination of ISM1745, a potentially best-in-class MTA cooperative PRMT5 inhibitor with AI-powered novel scaffold, as preclinical candidate (PCC) for the treatment of MTAP-deleted cancers.

2 Jan 2025

Blood cells linked to long-lasting vaccine immunity

When children receive their second measles-mumps-rubella vaccine, around the time they start kindergarten, they gain protection against all three viruses for all or most of their lives.

2 Jan 2025

Sleep deprivation disrupts brain regions that prevent unwanted memories

The link between poor sleep and mental health problems could be related to deficits in brain regions that keep unwanted thoughts out of mind, according to research from the University of East Anglia (UEA).

2 Jan 2025

Specialized bone marrow niches reveal secrets of immune tolerance

Researchers have uncovered a hierarchical structure of immune-privileged stem cells in bone marrow niches, revealing their regenerative potential and therapeutic relevance.

2 Jan 2025

Researchers develop tool to measure biological age in individual cell types

A new priority research paper, featured as the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22, was published on December 29, 2024. The paper is titled "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution."

2 Jan 2025

New artificial muscle mimics natural tissue with high elasticity and toughness

The study, led by Dr. Cheng-Hui Li from the School of Chemistry and Chemical Engineering, Nanjing University, and Dr. Pengfei Zheng from the Children's Hospital of Nanjing Medical University, successfully developed an artificial muscle with mechanical properties similar to natural muscle tissue.

2 Jan 2025

Histone markers predict human age with accuracy comparable to DNA methylation clocks

Researchers unveil histone-based age predictors, offering a new window into epigenetic aging and its shared patterns across tissues.

2 Jan 2025

New insights into tristetraprolin's impact on basophil-mediated allergic inflammation

Inflammation is a crucial part of the body's defense mechanism, playing a key role in fighting infections and repairing tissue damage.

2 Jan 2025

Psilocybin shows potential for treating mental health disorders in people with cancer and addiction

One or two doses of psilocybin, a compound found in psychedelic mushrooms, may improve the mental health of cancer patients when accompanied by psychotherapy, a new report suggests.

2 Jan 2025

New protein offers hope for heart regeneration

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish.

2 Jan 2025

Observational studies overestimate smoking's impact on CKD risk

A recent study published in Health Data Science led by Zhilong Zhang from the Institute of Medical Technology at Peking University Health Science Center and Professor Luxia Zhang from the National Institute of Health Data Science at Peking University has shed light on the complex relationship between smoking behavior and chronic kidney disease (CKD).

2 Jan 2025