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Researchers unveil drug complex that makes cancer cells self-report to immune system

Two junior research groups at Ruhr University Bochum, Germany, have developed a drug complex that kills cancer cells in such a clever manner that they raise a red flag as they die. They signal to the immune system that something is seriously wrong with this type of cell.

18 Jul 2025

Research highlights guselkumab's impact on Crohn's endoscopic healing

In a major advance for patients with Crohn's disease, a new study led by researchers at Mount Sinai Health System found that guselkumab, a medication with a mechanism of action that is new to inflammatory bowel disease (IBD) treatment, outperformed an established standard of care in promoting intestinal healing and symptom relief.

18 Jul 2025

Study identifies SDR42E1's role in vitamin D pathway

Vitamin D is not only an essential nutrient, but also the precursor of the hormone calcitriol, indispensable for health: it regulates the uptake of phosphate and calcium necessary for bones by the intestines, as well as cell growth and the proper function of muscles, nerve cells, and the immune system.

18 Jul 2025

Understanding brain activity during sleep to detect early neurological changes

"Complex processes are going on in the brain when we sleep," says Dr Karolina Armonaitė, a neuroscientist from Kaunas University of Technology, Lithuania. According to her, a more precise understanding of what happens in different areas of the cerebral cortex during sleep can help diagnose sleep disorders and neurological diseases more accurately.

18 Jul 2025

GLP-1 weight-loss drugs are reshaping modern dating and intimacy

GLP-1 weight-loss drugs are changing how people date and connect. In a nationally representative survey of 2,000 single U.S. adults (ages 18 to 91) led by the Kinsey Institute at Indiana University with DatingNews.com, GLP-1 users reported a wide range of physical, social, and psychological shifts they attributed to the drug.

18 Jul 2025

Retrospective analyses indicate Ozempic’s protective effects against stroke fatality

Three studies presented today at the Society of NeuroInterventional Surgery's (SNIS) 22nd Annual Meeting discussed whether using GLP-1 inhibitors could lessen the impacts of stroke and related brain injuries or reduce the risk of stroke altogether.

18 Jul 2025

New insights into brain fueling could lead to treatments for stroke, neurodegeneration

A new Yale study has revealed that neurons - the energy-hungry cells that connect and direct activity in the brain - are equipped with "backup batteries" that kick in to keep the brain running during periods of metabolic stress.

18 Jul 2025

Human eggs use a minimalist strategy to stay healthy for decades

Human eggs are some of the most patient cells in the body, lying dormant for decades until needed. A study published today in The EMBO Journal shows that the cells deliberately slow the activity of their internal waste disposal systems as they mature, most likely an evolutionary design which keeps metabolism low and damage at bay.

18 Jul 2025

Research challenges view on physical activity and global obesity crisis

A newly released study from Duke University's Pontzer Lab, housed in the Department of Evolutionary Anthropology in Trinity College of Arts & Sciences, looks at the correlations between economic development, daily energy expenditure and the rise in a country's obesity level.

18 Jul 2025

Advancing diagnostic accuracy in soft tissue cytopathology through WHO guidelines

Soft tissue cytopathology plays a vital role in the diagnosis and management of soft tissue neoplasms, necessitating a standardized classification system to improve diagnostic accuracy and guide clinical decision-making.

18 Jul 2025

PAR1 protein found to boost lung fluid drainage during injury

A protein called PAR1 helps lymphatic vessels structurally transform to boost fluid drainage and support healing when the lungs are injured according to researchers from Weill Cornell Medicine.

18 Jul 2025

Polyglycine aggregates disrupt tRNA splicing and drive neurodegeneration

Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, are devastating and incurable diseases.

17 Jul 2025

Uncovering a protective RNA molecule in kidney stress and disease

Cells contain helper molecules called transfer RNAs (tRNAs), which carry building blocks (amino acids) to make proteins.

17 Jul 2025

Specially engineered antibody delivers RNA therapy to treatment-resistant tumors

A specially engineered antibody capable of delivering RNA therapies to hard-to-reach, treatment-resistant tumors significantly shrank tumor size and improved survival in animal models, according to a study published July 16 in Science Translational Medicine.

17 Jul 2025

CRISPR-mediated DNA methylation editing regulates inflammation and tumor growth

Genes, fragments of DNA located on our chromosomes, control much of what happens in cells.

17 Jul 2025

New tool measures how quickly muscles age to predict sarcopenia risk

A new research paper was published in Aging (Aging-US) Volume 17, Issue 6, on June 9, 2025, titled "Developing a quantitative estimate of muscle age acceleration by a novel phenotypic clock: cross-sectional study in healthy, middle-aged and older adults."

17 Jul 2025

Study reveals how aging alters liver function and structure

The aging liver undergoes dramatic changes in its functional organization and other key attributes, which may underpin its increasing susceptibility to disease, according to a study led by investigators at Weill Cornell Medicine.

17 Jul 2025

Scientists create liver organoids with functional blood vessels

Liver organoids with proper blood vessel networks have been successfully produced, as reported by researchers from Institute of Science Tokyo and Cincinnati Children's Hospital Medical Center.

17 Jul 2025

Ripple activity in the brain helps organize and store episodic memories

A research team from the Faculty of Psychology at the University of Barcelona, the UB Institute of Neurosciences (UBneuro) and the Bellvitge Biomedical Research Institute (IDIBELL) has identified, for the first time in humans, and in a realistic environment, a key neurophysiological mechanism in memory formation: ripple-type brain waves —high-frequency electrical oscillations that mark and organize the different episodes or fragments of information that the brain stores as memories.

17 Jul 2025

Middle precentral gyrus plays key role in orchestrating speech movements

A new study from UC San Francisco challenges the traditional view of how the brain strings sounds together to form words and orchestrates the movements to pronounce them.

17 Jul 2025