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Immune cells navigate tissues with coordinated cytoskeletal forces

Immune responses rely on the efficient movement of immune cells within the complex and geometrically unpredictable three-dimensional tissues that make up our bodies.

21 Jul 2025

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells. Disruption of this enzyme altered cancer-related pathways and cell viability, highlighting its potential as a therapeutic target.

21 Jul 2025

Walking faster offers a simple solution to age-related frailty

Older adults who are prefrail or frail can increase their walking cadence through structured interventions, leading to significant gains in physical function. A rise in steps per minute was closely linked to meaningful improvements in walking endurance.

21 Jul 2025

AI-powered ECG model outperforms doctors in detecting hidden heart disease

Researchers developed an AI-powered ECG model, EchoNext, that detects structural heart disease with high accuracy across diverse hospitals and patient populations. The model outperformed cardiologists and could identify thousands of undiagnosed cases, potentially transforming cardiac screening.

21 Jul 2025

Muscle-derived vesicles heal damaged cells and reverse disease in new study

Researchers discovered that mitochondria-rich extracellular vesicles (Ti-mitoEVs) from skeletal muscle can deliver healthy mitochondria to damaged cells, restoring energy and promoting tissue repair in mice. The approach reversed acute muscle injury and chronic kidney disease, offering a promising new regenerative therapy.

21 Jul 2025

APOE ε4 variant reveals hidden risk factors beyond Alzheimer’s

Researchers discovered that people carrying the APOE ε4 gene variant share a unique immune-related protein signature across their blood, brain, and cerebrospinal fluid—regardless of neurodegenerative disease diagnosis. This signature reveals a fundamental, disease-independent vulnerability linked to APOE ε4, reframing our understanding of genetic risk in conditions like Alzheimer's, Parkinson’s, ALS, and FTD.

21 Jul 2025

Study identifies mechanism that helps prevent cancer, neurodegeneration, and premature aging

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the mechanism by which cells identify and repair a highly toxic form of DNA damage that causes cancer, neurodegeneration, and premature aging.

21 Jul 2025

Muscle loss from GLP-1 drugs could undermine long-term health

Popular GLP-1 drugs help many people drop tremendous amounts of weight, but the drugs fail to provide a key improvement in heart and lung function essential for long-term good health, University of Virginia experts warn in a new paper.

21 Jul 2025

The brain resolves sensory overload through rhythmic sampling

Recent research shows that your brain doesn't pay attention in one smooth stream-instead, it switches focus in quick bursts, about 8 times per second.

21 Jul 2025

Gene editing in the brain offers hope for ultra-rare neurological disease

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases.

21 Jul 2025

Novel polysaccharide from Albizzia julibrissin shows promise against pancreatic cancer

Albizzia julibrissin is a widely distributed plant in China. Its dried stem bark has been used in traditional oriental medicine to treat insomnia, diuresis, sthenia, ascaricide, and confusion.

21 Jul 2025

Study uncovers a specialized gut-brain pathway for glucose sensing

In a groundbreaking study, a research team at KAIST has uncovered a gut-brain circuit that enables the brain to selectively recognize glucose—beyond simply registering total caloric intake.

21 Jul 2025

Myeloid cells play central role in immune response after polytrauma

Gaining insights into the complex pathways and key cell populations involved in immune dysregulation can aid the development of therapeutic approaches to treat polytrauma, which is associated with poor patient outcomes.

21 Jul 2025

Gecko-inspired nanoparticles deliver targeted chemotherapy to tumors

As far back as the 4th Century B.C., Aristotle marveled at the nimble gecko's ability to "run up and down a tree in any way, even with the head downwards."

21 Jul 2025

Fluorescent bacteria enable real-time tumor visualization during surgery

Accurate removal of tumors is the most critical aspect of cancer surgery, yet it remains a significant challenge in clinical practice.

21 Jul 2025

Microbial signals rewire immunity in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with particularly high prevalence in East Asia.

21 Jul 2025

Goat milk boosts muscle health better than cow’s milk in animal study

Dairy products, especially low-fat and fortified goat milk, significantly improved muscle mass, reduced inflammation, and positively modulated gut microbiota in a mouse model of sarcopenia. These findings suggest tailored dairy interventions could help delay age-related muscle loss.

21 Jul 2025

Allergies linked to lower lung cancer risk, new study finds

A meta-analysis of nearly 3.9 million participants shows people with allergies have significantly lower odds of developing lung cancer. Allergic rhinitis is particularly protective, while eczema’s effect appears limited to men.

20 Jul 2025

Can probiotics help you sleep better?

A new meta-analysis shows that probiotic supplements can modestly improve sleep quality and reduce depressive symptoms in people with insomnia, with no significant safety concerns. However, effects on total sleep time and sleep efficiency remain uncertain, and evidence strength varies across outcomes.

20 Jul 2025

Overuse injuries spark lasting pain and mood changes through inflammation, rat study finds

Repetitive reaching tasks in mature female rats triggered persistent pain-like and sickness behaviors linked to a surge in IL-6-driven inflammation throughout muscles, blood, and the brain. These findings reveal how overuse injuries provoke both physical and mood-related symptoms through a neuroimmune cascade.

20 Jul 2025