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PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

Ferroptosis, a regulated cell death mechanism, is emerging as a promising target for cancer therapy. The process is mediated by the activity of acyl-CoA synthetase family member 4 (ACSL4) protein.

22 Sep 2025

Lysosomal acidity fine-tunes reactive species production in macrophages

Macrophages rely on lysosomes to balance microbial killing with self-protection, generating reactive oxygen and nitrogen species during phagocytosis.

21 Sep 2025

Daily actions are driven by habit rather than conscious choice

Habit, not conscious choice, drives most of our actions, according to new research from the University of Surrey, University of South Carolina and Central Queensland University.

21 Sep 2025

Coffee protects the liver by blocking inflammation and scarring, review finds

A new review in Biochemical Pharmacology synthesizes decades of research showing consistent links between regular coffee consumption and reduced risk of liver disease, including cirrhosis and liver cancer. Coffee’s bioactive compounds act on antioxidant, anti-inflammatory, antifibrotic, and metabolic pathways to slow liver damage progression.

21 Sep 2025

Do tongue piercings harm your oral health? Evidence points to yes

Researchers reviewed 19 studies on tongue piercings and found they carry significant oral health risks, including fractures, gum recession, infections, and rare systemic complications. The evidence base is limited but highlights the need for clinician vigilance and patient awareness.

21 Sep 2025

Study points to a surprising new ally in the fight against type 2 diabetes

A new study from Duke University School of Medicine is challenging long-standing views on blood sugar regulation - and pointing to a surprising new ally in the fight against type 2 diabetes.

19 Sep 2025

Metabolic activity found to control the tempo of embryo segmentation clock

Pregnant women rely on a balanced diet and supplements to deliver proper nutrients to their babies, to ensure they grow healthfully.

19 Sep 2025

Major federal grant supports health research and training in Arizona and New Mexico

The University of Arizona and the University of New Mexico received a seven-year, $43.6 million federal grant to fund a broad range of research programs aimed at improving the health of people living in Arizona and New Mexico, while also training a new generation of scientists and staff.

19 Sep 2025

New framework proposes lactate clearance as key marker for managing cardiogenic shock

A new initiative by The Society for Cardiovascular Angiography & Interventions (SCAI) proposes a new framework and call to action for managing cardiogenic shock (CS), establishing lactate clearance potentially as the standardized, time-based marker of patient trajectory to improve outcomes in one of the deadliest cardiovascular emergencies.

19 Sep 2025

SiCNet enables causal network construction at individual cell resolution

Causal inference is crucial in biological research, as it enables the understanding of complex relationships and dynamic processes that drive cellular behavior, development, and disease.

19 Sep 2025

Local abaloparatide injection promotes alveolar bone augmentation in orthodontic models

Alveolar bone, the specialized tissue within the jawbone, plays an important role in periodontal health.

19 Sep 2025

Cold exposure and mental fatigue show individual effects on endurance performance

Performance in endurance sports, such as long-distance running, cycling, and cross-country skiing, requires sustained activity over prolonged periods of time, and is influenced by multiple factors, such as temperature and mental state.

19 Sep 2025

Majority of parents disclose biological origins to their donor-conceived children

Four out of five parents tell their donor-conceived children about their biological origins, according to new research out of Waipapa Taumata Rau, University of Auckland.

19 Sep 2025

New cryopreservation technique reduces cracking risk in organ freezing

Cryopreservation, or preserving biological tissue by cooling it to subzero temperatures, may bring to mind works of science fiction.

19 Sep 2025

New research links postictal symptoms in epilepsy to hidden brain waves

In everyday clinical practice, symptoms are regularly observed after epileptic seizures, known as "post-ictal symptoms", which, in contrast to the usually short duration of seizures, typically last several minutes to hours. Besides symptoms such as impaired speech and language comprehension, a state of disorientation may occur.

19 Sep 2025

AGA releases new clinical guideline for diagnosing and managing gastroparesis

The American Gastroenterological Association (AGA) has released a new clinical guideline with 12 conditional recommendations for diagnosing and managing gastroparesis, a serious and often debilitating disease.

19 Sep 2025

AI tool analyzes brain activity to support and prioritize autism assessments

Scientists have developed and tested a deep-learning model that could support clinicians by providing accurate results and clear, explainable insights – including a model-estimated probability score for autism.

19 Sep 2025

New findings support low-dose ATG to delay progression of type 1 diabetes

New research presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) and published simultaneously in The Lancet shows that a much lower dose than previously thought of the old immunomodulatory drug anti-thymocyte globulin (ATG) is safe and effective in preventing progression of type 1 diabetes (T1D) in young people.

19 Sep 2025

Study identifies immune biomarkers for personalized therapies in pediatric germ cell tumors

A study conducted by the Molecular Oncology Research Center (CPOM) at Hospital de Amor in Barretos (formerly Barretos Cancer Hospital) in the state of São Paulo, Brazil, has identified possible biomarkers that could guide the development of more personalized therapies for pediatric germ cell tumors (GCTs).

18 Sep 2025

Study reveals how a little-understood protein contributes to blood vessel leakage

A new study from the University of Oklahoma reveals how a little-understood protein, CD82, contributes to blood vessel leakage, a process that initiates inflammation but becomes dangerous when it occurs during severe inflammatory diseases such as sepsis, acute respiratory distress syndrome and COVID-19.

18 Sep 2025

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Medical Science News

PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

Lysosomal acidity fine-tunes reactive species production in macrophages

Daily actions are driven by habit rather than conscious choice

Coffee protects the liver by blocking inflammation and scarring, review finds

Do tongue piercings harm your oral health? Evidence points to yes

Study points to a surprising new ally in the fight against type 2 diabetes

Metabolic activity found to control the tempo of embryo segmentation clock

Major federal grant supports health research and training in Arizona and New Mexico

New framework proposes lactate clearance as key marker for managing cardiogenic shock

SiCNet enables causal network construction at individual cell resolution

Local abaloparatide injection promotes alveolar bone augmentation in orthodontic models

Cold exposure and mental fatigue show individual effects on endurance performance

Majority of parents disclose biological origins to their donor-conceived children

New cryopreservation technique reduces cracking risk in organ freezing

New research links postictal symptoms in epilepsy to hidden brain waves

AGA releases new clinical guideline for diagnosing and managing gastroparesis

AI tool analyzes brain activity to support and prioritize autism assessments

New findings support low-dose ATG to delay progression of type 1 diabetes

Study identifies immune biomarkers for personalized therapies in pediatric germ cell tumors

Study reveals how a little-understood protein contributes to blood vessel leakage

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

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