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New insights reveal how TCF and LEF proteins control Wnt signaling and disease progression

Researchers have unveiled the intricate molecular mechanisms governing TCF/LEF-mediated transcription in the canonical Wnt pathway, identifying these proteins as promising therapeutic targets for cancer and fibrotic diseases.

7 Nov 2025

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

Glycans are important complex carbohydrates found on cell surfaces that serve crucial roles in cell-to-cell communication, structure, and protection.

7 Nov 2025

Scientists uncover mechanism driving efficient protein deacetylation by Sir2 enzyme

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation cycle of the Sir2 enzyme, reveal researchers from Science Tokyo.

7 Nov 2025

Exploring endogenous retroviruses as hidden drivers of alcohol use disorder

Alcohol use disorder (AUD), characterized by uncontrollable alcohol consumption due to physical and psychological dependence, affects approximately 14.1 million people in the U.S.

7 Nov 2025

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Cervical squamous cell carcinoma (CESC), the most prevalent subtype of cervical cancer, remains a major global health burden driven primarily by persistent high-risk HPV infection and genetic susceptibility.

7 Nov 2025

Mapping the brain's body regulation and sensing system using 7 Tesla MRI

Jiahe Zhang, PhD, of the Department of Psychiatry at Mass General Brigham, is the lead author of the paper published in Nature Neuroscience, "Cortical and subcortical mapping of the human allostatic-interoceptive system using 7 Tesla fMRI."

7 Nov 2025

Genomic mapping of resistance mutations in A. baumannii

The bacteria Acinetobacter baumannii (A. baumannii) is a haunting presence in many hospitals in the United States, where more than one in 100 patients are treated for A. baumannii infections.

7 Nov 2025

Comprehensive kinase atlas reveals new insights into cell signaling and disease

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns.

7 Nov 2025

New initiative focuses on advancing human disease research through AI and frontier biology

Mark Zuckerberg and Priscilla Chan today announced the launch of a first-of-its-kind initiative combining frontier artificial intelligence and frontier biology to dramatically accelerate scientific progress toward understanding and addressing human disease.

7 Nov 2025

Machine learning advances human-centric drug toxicity prediction

In the UK, there was a case where TGN1412, an immunotherapy under development, triggered a cytokine storm within hours of administration to humans, leading to multiple organ failure.

7 Nov 2025

Researchers identify a previously unknown cellular mechanism crucial to coronavirus replication

The discovery could serve as a starting point for antiviral strategies. A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated during infection with human coronavirus HCoV-229E and mediates the phosphorylation of the viral nucleocapsid (N) protein, an integral step in the virus cycle.

7 Nov 2025

New delivery particle could make mRNA vaccines cheaper and more effective

A new delivery particle developed at MIT could make mRNA vaccines more effective and potentially lower the cost per vaccine dose.

7 Nov 2025

BIOVECTRA and Revolution Biomanufacturing partner to deliver integrated mRNA Design and GMP production services

BIOVECTRA, a part of Agilent Technologies Inc., and Revolution Biomanufacturing Inc. today announced a collaboration that grants BIOVECTRA access to Revolution Biomanufacturing's proprietary platforms for optimizing untranslated regions (UTRs) and codon usage to enhance mRNA stability and translational efficiency.

6 Nov 2025

Intensive mind-body retreat rapidly alters brain function and blood biology

Researchers at the University of California San Diego have found that an intensive retreat combining multiple mind-body techniques, including meditation and healing practices, produced rapid and wide-ranging changes in brain function and blood biology.

6 Nov 2025

Engineered biomaterial promotes formation of cancer-fighting immune cell clusters

Researchers at Moffitt Cancer Center have developed a novel biomaterial-based system that induces the formation of tertiary lymphoid-like structures, or TLSs.

6 Nov 2025

SNAP benefits fail to fund healthy diets for many Americans, study shows

A new study reveals that while the Harvard Healthy Eating Pattern aligns with SNAP benefits, the Mediterranean and DASH diets often exceed allowable costs, particularly for individuals with higher calorie needs, highlighting a systemic “poverty tax” on healthy eating.

6 Nov 2025

Scientists turn human stomach cells into insulin-producing beta cells

Type 1 diabetes is caused by an insufficient production of the hormone insulin by cells in the pancreas called beta cells and estimated to affect 9.5 million people worldwide.

6 Nov 2025

Can creatine help with depression? New review says results are inconclusive

Creatine supplementation may modestly reduce depressive symptoms, but the effect is small, uncertain, and likely influenced by study bias. The evidence remains of very low quality, highlighting the need for larger, well-designed clinical trials.

6 Nov 2025

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Lowering the transcription factor PU.1 reprograms microglia into a neuroprotective, lymphoid-like state that compacts amyloid, blocks tau spread, and preserves synapses in Alzheimer’s disease. Microglial CD28 signaling helps restrain inflammation, revealing a regulatory switch that may inform future immunotherapies targeting microglia rather than neurons.

6 Nov 2025

Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

Long-term, low doses of THC mitigate many harmful side effects and inflammation caused by HIV and antiretroviral therapy (ART), according to new research from Texas Biomedical Research Institute.

6 Nov 2025

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Medical Science News

New insights reveal how TCF and LEF proteins control Wnt signaling and disease progression

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

Scientists uncover mechanism driving efficient protein deacetylation by Sir2 enzyme

Exploring endogenous retroviruses as hidden drivers of alcohol use disorder

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Mapping the brain's body regulation and sensing system using 7 Tesla MRI

Genomic mapping of resistance mutations in A. baumannii

Comprehensive kinase atlas reveals new insights into cell signaling and disease

New initiative focuses on advancing human disease research through AI and frontier biology

Machine learning advances human-centric drug toxicity prediction

Researchers identify a previously unknown cellular mechanism crucial to coronavirus replication

New delivery particle could make mRNA vaccines cheaper and more effective

BIOVECTRA and Revolution Biomanufacturing partner to deliver integrated mRNA Design and GMP production services

Intensive mind-body retreat rapidly alters brain function and blood biology

Engineered biomaterial promotes formation of cancer-fighting immune cell clusters

SNAP benefits fail to fund healthy diets for many Americans, study shows

Scientists turn human stomach cells into insulin-producing beta cells

Can creatine help with depression? New review says results are inconclusive

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

Extending the reach of Amperia™

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