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Inhibition of tumor xenograft growth in mice without systemic toxicity

The management of breast cancer involves various therapeutic approaches. However, many current anticancer treatments indiscriminately damage both cancerous and healthy cells. In cancer treatment, Streptomycetes have already been proven as the main resources producing anti-cancer drugs. Streptomyces coelicolor is a representative of the genus Streptomyces.

27 Mar 2025

Unveiling leptin signaling in the DMH for metabolic effects

Scientists at Pennington Biomedical Research Center have gained greater clarity in the brain regions and neurons that control metabolism, body temperature and energy use.

27 Mar 2025

Novel insights into tumor microenvironment and gastric cancer therapy

A team of Singapore scientists has made a significant discovery in understanding stomach cancer, a disease that remains one of the deadliest cancers worldwide. By using advanced mapping technologies, they created a detailed "atlas" of stomach tumors, revealing hidden patterns in how cancer cells behave, evolve and interact with their environment. These insights could lead to more precise, targeted treatments that improve survival rates and reduce side effects.

27 Mar 2025

Long Covid patients report dismissal and lack of support from healthcare providers

People living with Long Covid often feel dismissed, disbelieved and unsupported by their healthcare providers, according to a new study from the University of Surrey.

27 Mar 2025

Diagnostic colonoscopy follow-up unaffected by COVID-19 surge, despite screening delays

Two recent studies by researchers from Regenstrief Institute and the Indiana University School of Medicine explore the effect of the pandemic on colorectal cancer screening tests and diagnostic colonoscopies in Central Indiana. The findings of temporary disruption to the former and minimal impact on the latter are similar to findings across the U.S., contributing to the compendium of knowledge on preventive health uptake and subsequent treatment in various populations during the pandemic.

27 Mar 2025

Negative stiffness in calf muscles enhances high-speed hopping

Researchers at the University of Tokyo reveal the way our legs adapt to fast movements. When people hop at high speeds, key muscle fibers in the calf shorten rather than lengthen as forces increase, which they call "negative stiffness." This counterintuitive process helps the leg become stiffer, allowing for faster motion. The findings could improve training, rehabilitation, and even the design of prosthetic limbs or robotic exoskeletons.

27 Mar 2025

Glutamate key to unlocking liver regeneration after acute damage

The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, regeneration, which allows it to replace liver cells damaged by the very toxins that these cells eliminate.

26 Mar 2025

Cell's stress response is more nuanced and compartmentalized than previously thought

The body's cells respond to stress-toxins, mutations, starvation or other assaults-by pausing normal functions to focus on conserving energy, repairing damaged components and boosting defenses.

26 Mar 2025

New protein target could aid in muscle regeneration for degenerative conditions

For millions of people, losing muscle isn't just about weakness; it's about losing independence. Whether caused by Duchenne muscular dystrophy, aging or other degenerative conditions, muscle loss can make everyday activities – like walking, climbing stairs or even standing up – a daily struggle

26 Mar 2025

Study identifies PDGFRA as a potential target for pediatric high-grade gliomas

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

26 Mar 2025

Common sugar substitute increases activity in the brain's hypothalamus

Compared to sugar, consuming sucralose-a widely used sugar substitute-increases activity in the hypothalamus, a brain region that regulates appetite and body weight, according to a new USC study.

26 Mar 2025

Fusion proteins enable the creation of monoclonal antibodies

The Food and Drug Administration has approved more than 100 monoclonal antibodies to treat a range of diseases. Other antibodies are used by physicians to diagnose conditions or by scientists to advance research projects.

26 Mar 2025

Inflammation found to impact telomere length more than diet or exercise

A new research paper was published in Aging (Aging-US) on January 29, 2025, in Volume 17, Issue 2, titled "Diet, lifestyle and telomere length: using Copula Graphical Models on NHANES data."

26 Mar 2025

Pain can motivate young adults to co-use alcohol and cannabis

Contrary to popular belief, young adults can experience significant acute and even chronic pain - which can motivate them to use cannabis.

26 Mar 2025

Colorectal cancer burden climbs in countries with low milk intake

A global study finds that low milk intake is linked to increased colorectal cancer burden, especially in older adults. Prostate cancer rates showed negative trends, though the findings may reflect model limitations rather than protective effects.

26 Mar 2025

Lasso-shaped small molecule may be a powerful tool in the fight against infectious diseases

A small molecule shaped like a lasso may be a powerful tool in the fight against infectious diseases, according to a new study in Nature co-authored by University of Illinois Chicago researchers.

26 Mar 2025

Time-restricted eating combined with exercise may boost fat loss

Time-restricted eating is the latest craze for people looking to lose weight, but whether it works is still the calorie-burning question.

26 Mar 2025

Study uncovers protective mechanism of BRCA2 in cancer treatment

Mutations in BRCA2 — a gene known to repair damaged DNA and suppress tumor formation — can predict an individuals' predisposition to develop breast cancer, ovarian, prostate, pancreatic, and other epithelial tumors.

26 Mar 2025

Novel drug nitisinone could help reduce malaria spread by killing mosquitoes

In the fight against malaria, controlling the mosquito population is crucial.

26 Mar 2025

Researchers develop a reverse genetics system for African swine fever virus

Researchers from the J. Craig Venter Institute (JCVI), the Friedrich-Loeffler-Institut (FLI), and the International Livestock Research Institute (ILRI) have developed a reverse genetics system for African swine fever virus (ASFV).

26 Mar 2025