Cirrhosis

Cirrhosis is a condition in which the liver slowly deteriorates and malfunctions due to chronic injury. Scar tissue replaces healthy liver tissue, partially blocking the flow of blood through the liver.

What is Cirrhosis?

Cirrhosis is a severe form of liver disease wherein normal liver tissue is replaced by scar tissue (fibrous tissue).

What Causes Cirrhosis?

Managing and Treating Cirrhosis

Liver Disease Symptoms

Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population from 2016 to 2019.

25 Jul 2024

New study helps better understand the pathology of fatty liver disease MASH

A new study brings researchers closer to better understanding the pathology of the fatty liver disease MASH, which stands for metabolic dysfunction-associated steatohepatitis.

24 Jul 2024

Stroop-CN: A rapid diagnostic tool for minimal hepatic encephalopathy

This study is led by Dr. Xiaolong Qi (Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology) and Dr. Junliang Fu (Senior Department of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases).

19 Jul 2024

Navigating adjuvant therapy options in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally and is the third leading cause of cancer-related deaths.

16 Jul 2024

Ultrasound techniques for the surveillance, diagnosis, and treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and one of the leading causes of cancer-related deaths worldwide. Early detection and accurate diagnosis are crucial for effective management and improved survival rates.

16 Jul 2024

Existing drug shows promise for treating common liver disease

The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people. The drug has long been marketed in Japan for another use: improving blood lipid levels in patients with hyperlipidaemia, a common condition in diabetics. Now, however, it could help address this serious liver disease, which still has no specific treatment.

11 Jul 2024

Aging aggravates liver fibrosis in Down Syndrome, new study finds

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 12, entitled, "Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome."

10 Jul 2024

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

10 Jul 2024

Asia Pacific faces hepatitis crisis: Urgent action needed to meet WHO targets

Countries in Asia Pacific are unlikely to meet their commitment to eliminate hepatitis by 2030 unless they declare a public health emergency, as they did with COVID-19, a disease specialist suggested.

1 Jul 2024

Duke researchers discover drug to restore aged livers

While the liver is one of the body's most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure.

26 Jun 2024

Personal choices drive young adults' alcohol abstinence with cannabis as a common substitute

Personal decisions, such as disinterest and avoiding drunkenness, are the primary reasons young adults abstain from alcohol, with financial concerns also playing a significant role, according to a recent study.

24 Jun 2024

UT Health San Antonio researcher wins NIH grant to investigate alcohol-associated liver disease

Liver transplants associated with alcohol-related disease are growing at a rapid pace, shifting research to address pathologies behind the ailments in light of a limited supply of organ donors.

21 Jun 2024

Innovative liver patch shows promise in tissue regeneration

As described in research published in the Biotechnology Journal, investigators have developed a novel patch that can help liver tissue regenerate.

12 Jun 2024

Sedentary childhood linked to premature liver damage, study finds

An increase in sedentary time from childhood caused premature liver damage, a new study shows. However, light physical activity could reverse the risk.

6 Jun 2024

Childhood inactivity linked to increased risk of liver disease by young adulthood

Children who are sedentary for more than six waking hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood, a new study finds.

3 Jun 2024

Evaluating systemic thrombolysis for acute portal vein thrombosis in cirrhotic patients

The prevalence of Portal Vein Thrombosis (PVT) varies significantly at different stages of liver disease: 10% in compensated patients, 17% in decompensated patients, 9% in those with acute decompensated cirrhosis, and 2-26% in post-liver transplant patients.

24 May 2024

Key studies on GLP-1 drugs, alpha-gal syndrome, and liver disease medications to be presented at DDW 2024

Studies examining the risks of GLP-1 weight-loss drugs, distinguishing alpha-gal syndrome from other GI disorders, and comparing medications to slow the progression of liver disease in patients with alcohol-use disorder will be presented this week at Digestive Disease Week (DDW) 2024.

21 May 2024

Metabolomic analysis sheds light on gut microbes' role in cardiovascular disease risk

The effect of gut bacteria on non-high-density lipoprotein cholesterol (non-HDL-c) variations.

14 May 2024

Intermittent fasting halts liver disease progression and reduces cancer risk

Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development.

8 May 2024

Differences in leading causes of disease burden between males and females

A recent study reveals that males bear a higher disease burden overall, while females experience a higher burden from seven specific conditions, emphasizing the need for tailored health interventions.

5 May 2024