Cirrhosis

Cirrhosis is a condition in which the liver slowly deteriorates and malfunctions due to chronic injury. Scar tissue replaces healthy liver tissue, partially blocking the flow of blood through the liver.

What is Cirrhosis?

Cirrhosis is a severe form of liver disease wherein normal liver tissue is replaced by scar tissue (fibrous tissue).

Liver Disease Symptoms

What Causes Cirrhosis?

Managing and Treating Cirrhosis

Richmond Pharmacology highlights encouraging first-in-human results for Regeneron's investigational RNAi therapy in MASLD

Richmond Pharmacology, a specialist early-phase clinical research organization, has announced encouraging results from a first-in-human clinical trial evaluating CIDEBsiRNA, an investigational RNA interference (RNAi) therapy developed by Regeneron Pharmaceuticals, Inc.

12 Nov 2026

Liver transplants dramatically extend survival for alcohol-associated liver disease

People with alcohol-associated liver disease who received a liver transplant survived years longer than those who did not, but there are disparities in which patients receive a transplant.

9 Nov 2026

New nanovesicle therapy shows promise for treating alcohol-related liver disease

Alcohol-related liver disease (ALD) is characterized by hepatocellular injury, oxidative stress, inflammation, and extracellular matrix remodeling, yet effective therapies remain limited.

4 Nov 2026

Major studies identify accurate non-invasive tests for liver disease

Two major international studies have delivered the strongest evidence to date on which non-invasive tests can accurately diagnose and measure the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) and its more severe form, MASH, reducing reliance on liver biopsy.

29 Oct 2026

AI tool reads abdominal ultrasounds and accelerates emergency diagnoses

When a patient arrives in the emergency department with severe abdominal pain, every minute counts. Researchers at the University of Colorado Anschutz School of Medicine are investigating ways to streamline the work of radiologists and make it more efficient.

29 Oct 2026

New research center aims to accelerate hepatitis C vaccine development

The shifty hepatitis C virus (HCV) has a knack for outmaneuvering the immune system. Its secret is an especially high mutation rate, which has generated an abundance of viral variants with extreme genetic diversity.

27 Oct 2026

AGA/AASLD joint guideline evaluates newer medications for primary biliary cholangitis

For the first time, a joint guideline from the American Gastroenterological Association (AGA) and American Association for the Study of Liver Diseases (AASLD) evaluates newer medications for primary biliary cholangitis (PBC), the most common cholestatic disease in adults.

22 Oct 2026

Routine liver cancer screening extends lives for patients with alcohol-associated cirrhosis

A new study led by investigators from Mass General Brigham found routine liver cancer screening to be cost-effective and life-extending for individuals with alcohol-associated cirrhosis, even when their annual risk of developing liver cancer is less than half the risk level guiding current screening recommendations.

20 Oct 2026

New AI model detects hidden diseases in routine CT scans

When analyzed by a new artificial intelligence model developed at Penn Medicine, CT scans reveal much about a patient's health beyond the specific condition they were originally ordered for, according to a new study published in NPJ Digital Medicine.

20 Oct 2026

Mursla Bio publishes peer-reviewed validation of tissue-specific extracellular vesicle platform for liquid biopsy

Mursla Bio, a precision medicine and diagnostics company built on tissue-specific extracellular vesicles (TS-EVs), today announced publication of a peer-reviewed study in the Journal of Extracellular Vesicles (impact factor 21.7), the founding journal of the International Society for Extracellular Vesicles. This validates the TS-EV platform for a new class of liquid biopsy: the multiomic disease biology of living cells in a chosen tissue, read from blood, starting with the liver.

From Mursla Bio 13 Oct 2026

Late-night snacking may affect liver health

New research led by Oregon Health & Science University suggests you should think twice about indulging in a late-night snack if you'd like to preserve liver health.

9 Oct 2026

Scientists discover how excess dietary salt drives 'lean MASH'

Fatty liver disease is commonly associated with obesity, yet a growing number of people with normal body weight develop a severe form of the condition.

29 Sep 2026

Baseline liver fibrosis severity predicts treatment response in patients with HBeAg-positive CHB

The impact of baseline liver fibrosis severity on the effectiveness of pegylated interferon (Peg-IFN) combined with nucleos(t)ide analogs (NAs) in the treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) has not been fully clarified.

23 Sep 2026

Siemens Healthineers and Novo join forces to advance care for people living with MASLD and MASH

Siemens Healthineers and Novo have announced a collaboration focused on advancing care for people living with metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH).

From Siemens Healthineers 22 Sep 2026

Celastrol reduces cholestatic liver injury by inhibiting specific protein

Cholestasis occurs when bile formation, secretion, or flow is impaired, causing toxic bile acids to accumulate and trigger inflammation and liver-cell damage.

17 Sep 2026

Study identifies bile acid that helps reduce excess fat accumulation in the liver

Non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD), is a common condition that causes excess fat to build up in the liver, affecting about one-quarter of adults worldwide.

17 Sep 2026

Study defines early-onset cirrhosis caused by fatty liver disease

Researchers at University of California San Diego School of Medicine have published the first study to define early-onset cirrhosis caused by metabolic dysfunction-associated steatotic liver disease (MASLD), a condition known as fatty liver disease.

16 Sep 2026

Could scorpion venom inspire new treatments for liver disease?

Scorpion venom peptides show promising anti-inflammatory, antiviral, analgesic, and immunomodulatory effects, with experimental evidence suggesting that some candidates could target pathways involved in chronic liver disease and viral hepatitis. The review highlights Kv1.3-blocking peptides and antiviral compounds as potential therapeutic leads, while emphasizing that limited hepatic efficacy data, poor pharmacokinetics, immunogenicity, and manufacturing challenges must be overcome before clinical translation.

8 Sep 2026

Gut bacterial molecule discovered to drive serious bile duct disease

Researchers at the University of Oslo and Oslo University Hospital have, together with international collaborators, discovered that a small molecule made exclusively by gut bacteria can actively drive disease in the bile ducts and worsen primary sclerosing cholangitis (PSC), a serious liver and bile duct disease.

4 Sep 2026

Alcohol-related liver cancer deaths were falling. Then the trend reversed during the COVID-19 pandemic

A global analysis of GBD 2023 data found that alcohol-attributable liver cancer mortality increased modestly from 1990 to 2023, while mortality from alcohol-attributable cirrhosis, alcoholic cardiomyopathy, and alcohol use disorders declined. Liver cancer mortality shifted from a pre-pandemic decline to an increase during 2020–2023, particularly among women, although the researchers cautioned that the ecological analysis cannot establish that pandemic-related changes caused the reversal.

1 Sep 2026

Cirrhosis

Overview

Liver Disease Symptoms

What Causes Cirrhosis?

Managing and Treating Cirrhosis

Latest Cirrhosis News and Research

Richmond Pharmacology highlights encouraging first-in-human results for Regeneron's investigational RNAi therapy in MASLD

Liver transplants dramatically extend survival for alcohol-associated liver disease

New nanovesicle therapy shows promise for treating alcohol-related liver disease

Major studies identify accurate non-invasive tests for liver disease

AI tool reads abdominal ultrasounds and accelerates emergency diagnoses

New research center aims to accelerate hepatitis C vaccine development

AGA/AASLD joint guideline evaluates newer medications for primary biliary cholangitis

Routine liver cancer screening extends lives for patients with alcohol-associated cirrhosis

New AI model detects hidden diseases in routine CT scans

Mursla Bio publishes peer-reviewed validation of tissue-specific extracellular vesicle platform for liquid biopsy

Late-night snacking may affect liver health

Scientists discover how excess dietary salt drives 'lean MASH'

Baseline liver fibrosis severity predicts treatment response in patients with HBeAg-positive CHB

Siemens Healthineers and Novo join forces to advance care for people living with MASLD and MASH

Celastrol reduces cholestatic liver injury by inhibiting specific protein

Study identifies bile acid that helps reduce excess fat accumulation in the liver

Study defines early-onset cirrhosis caused by fatty liver disease

Could scorpion venom inspire new treatments for liver disease?

Gut bacterial molecule discovered to drive serious bile duct disease

Alcohol-related liver cancer deaths were falling. Then the trend reversed during the COVID-19 pandemic

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

Cirrhosis

Overview

Latest Cirrhosis News and Research

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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