Constipation

Constipation is a condition in which stool becomes hard, dry, and difficult to pass, and bowel movements don’t happen very often. Other symptoms may include painful bowel movements, and feeling bloated, uncomfortable, and sluggish.

What is Constipation?

Constipation is a condition characterized by inability to pass stools that become hard and more difficult to pass.

Constipation Diagnosis

Constipation in Children

Constipation Prevention

Constipation Symptoms

Constipation in the Elderly

Constipation in Babies

Causes of Constipation

Drugs that Cause Constipation

Slow Transit Constipation

Constipation Treatments

Latest Constipation News and Research

Piezo ion channels: Key regulators of digestive health and disease

Mechanosensitive Piezo ion channels, particularly Piezo1 and Piezo2, are gaining recognition as central regulators of digestive system physiology and disease.

7 Aug 2026

Hypothyroidism linked to higher risk of obstructive sleep apnea

According to a study conducted in Brazil by researchers at the Federal University of São Paulo (UNIFESP) with participants from the São Paulo Epidemiological Sleep Study (EPISONO 2018), people with hypothyroidism experience a higher frequency and severity of obstructive sleep apnea (OSA).

5 Aug 2026

Biofortified millet improves toddler gut health without adverse effects

Toddlers who ate iron- and zinc-biofortified pearl millet for nine months did not experience adverse effects typically associated with increased iron intake and developed gut microbiomes with distinct and potentially beneficial changes, according to a new study led by researchers at Cornell University's Joan Klein Jacobs Center for Precision Nutrition and Health.

5 Aug 2026

Review outlines effective approaches to reduce recurrent hepatic encephalopathy

Hepatic encephalopathy (HE) is a neurologic complication of advanced liver disease, causing impaired functioning, reduced quality of life (QOL), and increased hospitalisation and mortality.

31 Jul 2026

Time zone changes disrupt vital gut bacteria during travel

A dream holiday, an exotic destination, a long-haul flight, and finally some well-deserved rest. The problem is that many travelers arrive at their destination only to spend the first days of their vacation struggling with fatigue, sleep disturbances, low energy levels, and digestive issues.

23 Jul 2026

Vitamin D falls short as an add-on treatment for endometriosis

An eight-week randomized trial of 66 women found that adjunctive vitamin D did not significantly or meaningfully improve endometriosis pain or quality of life compared with placebo during dienogest therapy. The results do not support routine short-term adjunctive supplementation, although the brief trial and absence of post-treatment vitamin D measurements leave longer-term effects uncertain.

19 Jul 2026

Semaglutide outperforms other GLP-1 drugs for weight loss in psychiatric populations

A network meta-analysis of nine randomized controlled trials found that once-weekly semaglutide showed the largest estimated weight-loss effect among GLP-1 receptor agonists tested in adults with mental illness and obesity or related metabolic risk. The authors cautioned that the findings remain preliminary because the evidence base was small, heterogeneous, and largely indirect.

9 Jul 2026

Genetic research reveals surprising metabolic pathway for irritable bowel syndrome

Irritable bowel syndrome (IBS) is a common condition that affects more than 10% of the general population, causing recurrent abdominal pain, bloating, constipation and diarrhea.

9 Jul 2026

University of Malaga scientists find way to improve morphine treatments

Scientists at the Department of Cell Biology of the University of Malaga have taken a step forward in the search for more effective treatments for pain with a new study that continues advancing in mitigating the addictive effects of morphine -one of the main drugs used for this purpose- as well as the development of analgesic tolerance to this drug.

9 Jul 2026

Fiber blend relieves constipation and improves stool consistency

A recent study found that a combination of dietary fibers effectively alleviated chronic constipation, enhancing bowel function and stool quality in adults.

30 Jun 2026

Short-chain oat fiber helps steady glucose and ease gut symptoms in pilot trial

A 14-day open-label pilot study in 63 healthy adults found that short-chain oat fiber was well tolerated at doses up to 20 g/day and was associated with improved gastrointestinal symptom scores.

14 Jun 2026

Oral GLP-1 drug elecoglipron helps adults lose up to 11.8% body weight

Once-daily oral elecoglipron produced dose-dependent weight loss in adults with obesity or overweight without diabetes, with mean reductions reaching 10.5% at 26 weeks and 11.8% at 36 weeks in the highest-dose weekly-titration group. The phase 2 trial found no evidence of a weight-loss plateau by 36 weeks, while gastrointestinal adverse events were common but generally manageable.

11 Jun 2026

Western diet weakens the gut’s nervous system through iron-dependent damage

A JCI study found that exposure to a Western diet in mice and to palmitic acid in murine and ex vivo human enteric nervous system models triggered ferroptosis, characterized by iron loading, lipid peroxidation, mitochondrial stress, and enteric neuronal loss. Boosting Nrf2 signaling protected enteric neurons and prevented Western diet-induced delayed colonic transit in mice, pointing to a potential pathway linking dietary fat exposure to gut motility dysfunction.

10 Jun 2026

Constipation may be tied to more than discomfort

Constipation was associated with approximately twofold higher odds of depression in a meta-analysis of 18 observational studies involving 730,263 participants. The findings support integrated gastrointestinal and mental health assessment, especially for adolescents and young adults, while emphasizing that causality cannot yet be established.

3 Jun 2026

Children left waiting up to two years for NHS continence care, new data reveals

Children with bladder and bowel conditions are waiting months – and in some cases years – for specialist NHS support, as overstretched continence services struggle to meet rising demand, new Freedom of Information (FOI) data reveals.

29 May 2026

Could guava juice help prevent anemia?

Guava juice intake is linked to increased hemoglobin levels in females, highlighting its role as a dietary complement to traditional iron supplementation.

29 May 2026

Once-daily orforglipron helps preserve weight loss after semaglutide or tirzepatide

Oral orforglipron helped adults maintain clinically meaningful weight loss after prior injectable tirzepatide or semaglutide therapy. The phase 3b ATTAIN-MAINTAIN trial suggests switching to once-daily oral therapy may help reduce weight regain when injectable treatment is discontinued.

13 May 2026

Survey finds one in three women suffer silently with pelvic prolapse

Up to half of all women will experience some degree of pelvic organ prolapse in their lifetime. The condition can cause incontinence, constipation and the descent of the bladder or uterus into the vagina.

13 May 2026

Study challenges structural explanation for gut symptoms in hEDS patients

A study, led by experts at the University of Nottingham, has found that persistent and distressing upper gut symptoms experienced by people with hypermobile Ehlers-Danlos syndrome (hEDS), are not due to structural problems with the gullet (esophagus), as previously assumed.

13 May 2026

Semaglutide shows sustained weight loss benefits in older adults

A new analysis of the STEP trails carried out by semaglutide manufacturer Novo Nordisk has analysed various trials to show the safety and efficacy of the obesity drug semaglutide in older adults (over 65 years), and found similar efficacy and safety as in the general trial populations .

11 May 2026