Depression

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life.

Clinical Depression: Diagnosis, Causes & Treatment

Depression is a clinical condition that, contrary to popular opinion, cannot simply be overcome with time and it needs to be treated.

The Science Behind the Winter Blues: Understanding Seasonal Affective Disorder

How is Depression in Children Diagnosed?

Supporting Children with Mental Health Disorders

Contributing Factors to Post-Adoption Depression

Genes and Depression

Can Depression and Anxiety Occur Together?

Symptoms of Depression

Depression and Sleep Length

Ghrelin and Depression

How Does Your Diet Affect Depression?

Treatment Options for Children with Depression

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Link Between Chronic Illness and Depression

Prisoner Depression and Low Mood

Intrusive Thoughts and Depression

How Can I Tell if My Child is Depressed?

Food Insecurity and Depression

Depression in children

Treatment of Depression

Antidepressants and Weight Changes

Situational Depression: Symptoms, Causes, Treatments

Causes of Depression

5 Facts You May Not Know About Depression

Depression Diagnosis

Latest Depression News and Research

Neighborhood environments impact long-term health of 9/11 responders

Twenty-five years after the September 11 terrorist attacks, researchers at the Icahn School of Medicine at Mount Sinai have found that environmental conditions where World Trade Center responders live may influence their long-term physical and mental health.

11 Sep 2026

AI identifies hidden biological patterns to accurately diagnose migraines

AI can trawl vast amounts of health data which is not specifically related to migraines, but which can be used to identify people predisposed to the condition.

11 Sep 2026

Liberian women face long waits for urgent fistula surgery

For more than three years, Lorpu has lived with the constant leakage of urine and faeces caused by obstetric fistula, a debilitating childbirth injury.

11 Sep 2026

Medicaid ACOs can improve maternal care quality and equity

A new study details how Medicaid Accountable Care Organizations can improve maternal healthcare quality and equity in the US by aligning performance mandates with innovative care coordination and social needs support among patients before, during, and after pregnancy.

10 Sep 2026

Breast cancer AI test finds no single chatbot excels across every measure

Researchers compared five large language models on breast cancer health information using 90 knowledge questions, 10 clinical cases, and 20 common patient concerns, with all prompts submitted in simplified Chinese. The models performed strongly on standardized knowledge overall, but differed in linguistic complexity and expert-rated completeness, readability, helpfulness, correctness, and safety.

10 Sep 2026

Prediabetes linked to substantial burden of mental health conditions

Announcing a new article publication for BIO Integration. Prediabetes has a high prevalence worldwide; however, the prevalence of mental health conditions within the population with prediabetes is not well understood.

10 Sep 2026

Five minutes of coffee aroma was linked to shifts in mood and brain activity

Short-term coffee aroma exposure was followed by reductions in several negative mood measures and an increase in an EEG-derived relaxation index in 20 healthy young adults. Heart rate and HRV did not change significantly, and the uncontrolled study cannot establish that coffee aroma caused the observed responses.

10 Sep 2026

Review highlights solute carriers as targets for central nervous system disorders

Solute carriers (SLCs) are specialized transport proteins that control the movement of nutrients, ions and neurotransmitters across cell membranes and are essential for brain metabolism and neuronal communication.

10 Sep 2026

Tizanidine looked promising early in a migraine trial, but the benefit did not last

A randomized, double-blind, placebo-controlled trial found that low-dose tizanidine did not provide sustained reductions in headache burden over 12 weeks in people with episodic migraine, despite a transient improvement with the 1 mg dose at week 4. Exploratory analyses suggested that smoking and sex may influence tizanidine exposure, while sex-specific efficacy signals remained hypothesis-generating and require confirmation.

10 Sep 2026

Early pregnancy emotions may predict childhood developmental delay risks

Pregnancy is often one of the biggest emotional and physical transitions in a woman's life. Alongside the well-known physical changes, many women also experience shifts in mood and mental health during pregnancy and after giving birth, with anxiety and depression being quite common.

9 Sep 2026

Digital program reduces burnout and anxiety in distressed nurses

Burnout, depression, anxiety, and suicide are increasing in the nursing and overall health care workforce, which adversely impacts health care quality and safety.

9 Sep 2026

Astrocyte changes may explain how stress affects mental health

A new study led by UCLA Health researchers has identified a specific type of brain cell and a tiny structure on its surface that changes when the body is under stress, which may help explain why stress can lead to anxiety and depression.

8 Sep 2026

Integrated mental health care could transform Canada's primary care

As Prime Minister Mark Carney prepares to host the inaugural Canada Investment Summit in Toronto this September, a new review co-led by researchers at UBC argues that the country is leaving one of its largest economic and health-care system opportunities untouched: the integration of psychological care into primary care.

8 Sep 2026

Ultrasonic vocalizations in rats linked to pleasurable food consumption

Understanding how the brain processes rewarding experiences could help researchers better understand behaviors such as overeating, as well as conditions such as anhedonia-the inability to experience pleasure, which is a common symptom of depression.

8 Sep 2026

Why do older adults often feel better emotionally? Mindfulness may be part of the answer

In a cross-sectional U.S. sample of 129 adults, older age was associated with greater positive and lower negative emotional well-being, alongside greater dispositional mindfulness and lower neuroticism. Lower neuroticism statistically accounted for age differences in both positive and negative well-being, while mindfulness statistically accounted for differences in negative well-being only, although the study cannot establish causality.

8 Sep 2026

GLP-1 drugs looked promising for depression. The evidence tells a more complicated story

A systematic review of 43 studies found highly heterogeneous results for GLP-1 receptor agonists across animal models and human research assessing depression-, anxiety-, and stress-related outcomes. No study directly tested these drugs as a treatment for PTSD, and the available evidence does not currently support their use for depression or PTSD, although people with metabolic dysfunction may warrant further investigation.

7 Sep 2026

Psilocybin microdosing sounds promising, but the strongest studies tell a different story

A systematic review of 11 studies involving 3,262 adults found that psilocybin mushroom and truffle microdosing was associated with reported improvements across areas including mental health, well-being, cognition, creativity, and social functioning. However, the evidence was methodologically weak and highly heterogeneous, the two placebo-controlled trials found no significant improvements, and inadequate adverse-event reporting means efficacy and safety remain uncertain.

7 Sep 2026

GLP-1 drugs appear psychiatrically safe, but one finding still raises questions

A systematic review of 11 observational studies representing more than 4.9 million patients found that GLP-1 receptor agonists were generally associated with neutral or potentially protective psychiatric outcomes, although one obesity-focused cohort reported increased risks of depression, anxiety, and suicidal behavior. Direct evidence for antidepressant effects remains limited, with only one cross-sectional study using validated mood scales and no randomized trials in the final synthesis, meaning causality cannot be established

6 Sep 2026

Some popular drinks were linked to depression and anxiety. Coffee was different

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6 Sep 2026

Mental health warning labels prompt young people to limit screens

Pop-up messages that warn of the harms of social media - such as mental health consequences - have potential to reduce young people's social media use, a new Stanford Medicine study has found.

4 Sep 2026