Diarrhea News and Research

Latest Diarrhea News and Research

A closer look at TMPRSS2: This could help treat COVID-19

The transmembrane protease serine-type 2 (TMPRSS2) protein plays a key role in COVID-19 infection since it primes the viral spike protein to allow viral entry into the target cell. A new study by researchers at Imperial College London and published on the preprint server bioRxiv in May 2020 describes the protein, which could be an attractive drug target to help manage COVID-19.

28 May 2020

Mouse model mimics clinical course and pathology observed in COVID-19 patients

A mouse model of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reproduces features observed in human patients, researchers report May 26 in the journal Cell Host & Microbe.

27 May 2020

A key player in hepatitis A virus infection discovered

How hepatitis A virus manages to enter liver cells called hepatocytes and initiate infection had remained a mystery for fifty years until now.

26 May 2020

ACE2 receptors for SARS-CoV-2 in human eye

Since its emergence in Wuhan, China, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly over most of the world’s inhabited regions, causing millions of cases and hundreds of thousands of deaths. The primary symptoms of COVID-19, the disease caused by SARS-CoV-2, are fever, dry cough, and tiredness.

25 May 2020

Immunotherapy, steroids restore heart function in children with COVID-related multi-system inflammatory syndrome

Treatment with antibodies purified from donated blood - immune globulin therapy - and steroids restored heart function in the majority of children with COVID-related multi-system inflammatory syndrome, according to new research published yesterday in Circulation, the flagship journal of the American Heart Association.

19 May 2020

Steroids and immunotherapy improve outcomes in children with COVID-related multi-system inflammatory syndrome

19 May 2020

Most Australians do not understand difference between bacterial and viral infection

Public awareness matters amid the coronavirus disease (COVID-19) pandemic; however, a new study shows that more than 92 percent of the Australian population cannot differentiate between a bacterial and viral infection.

18 May 2020

Kawasaki disease outbreak in children with COVID-19

The ongoing COVID-19 pandemic has marched its way to almost all parts of the world, with hundreds of thousands of deaths and over 4.5 million cases as of May 15, 2020. One saving grace has been the apparent sparing of children, though the mortality in older people is quite high.

17 May 2020

Rotavirus infection mainly affects children under 5 years of age

A research team from the University of Valencia has carried out a study of infection and immunity markers by detecting antibodies in the blood of 7 different genotypes of the rotavirus VP8 protein, the virus that causes infectious diarrhoea, and concludes that more frequent types mainly affect the child population.

14 May 2020

Low albumin levels could predict poor outcome in COVID-19

A Spanish study has revealed that COVID-19 patients who have a low level of albumin have a poorer outcome compared to those with normal levels of blood albumin. The study titled, “Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study,” was released prior to peer-review on the open-access preprint server site Medrxiv*.

13 May 2020

Analysis of single-cell data indicates that SARS-Cov-2 targets many cell types

Before it can sicken people, the new coronavirus must first sneak into their cells. But not any cell will do. The virus can enter only those with a certain combination of molecules on their surfaces.

13 May 2020

Rotavirus vaccination leads to a decrease in hospitalizations and deaths of children

Vaccination against rotavirus has led to a significant decrease in hospitalisations and deaths of children due to severe diarrhoea in the Western Pacific region, a new study has found.

12 May 2020

Study: Diarrhea-causing bacteria provoke host's response to increase infectivity

A type of E. coli bacteria that causes bloody diarrhea uses an amino acid produced by the body in response to infection to intensify its symptoms, according to a new study from UT Southwestern scientists.

12 May 2020

Study shows how diarrhea-causing bug finds its way through the human gut

A study from UT Southwestern researchers sheds new light on how the bug that's the No. 1 cause of bacterial diarrhea finds its way through the human gut.

12 May 2020

Antiviral cocktail may help treat mild COVID-19 patients

The skyrocketing number of cases due to the coronavirus pandemic has taken a massive toll on the health systems in many countries. Since the advent of the coronavirus disease (COVID-19), hundred of research teams are racing to find an effective vaccine and treatment to combat the deadly infection. Now, a team of researchers in Hong Kong suggests that combining three existing antivirals may help treat COVID-19 patients.

12 May 2020

No evidence COVID-19 is spread by fecal-oral transmission

A new study published on the preprint server medRxiv* in May 2020 shows that in patients who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pharyngeal and fecal samples, the virus persists longer in the fecal samples than in the pharyngeal samples. However, fecal-oral transmission does not appear to occur.

10 May 2020

Study demonstrates dynamic and broad-scale immune alterations in COVID-19 patient

A new case report released on the preprint server medRxiv* provides a detailed longitudinal analysis of the immune response associated with a fatal case of coronavirus disease (COVID-19). It highlights the need for addressing the source of hyper inflammation in the treatment approach.

10 May 2020

Predicting the dose for repurposing nitazoxanide in COVID-19

A new study published on the preprint server medRxiv in May 2020 reports a model that could help evolve appropriate dosage protocols for future clinical trials of the repurposed drug nitazoxanide in COVID-19 prevention and treatment. The researchers say, “It was possible to achieve plasma and lung tizoxanide concentrations, using proven safe doses of nitazoxanide, that exceed the EC90 for SARS-CoV-2.”

7 May 2020

Some foods common in diets of adults with inflammatory bowel disease

American researchers from the Institute for Biomedical Sciences at Georgia State University have found that certain foods such as cheese, cookies, French fries, energy drinks, soda, and other types of junk foods are found more frequently in the diets of adults suffering from inflammatory bowel disease (IBD).

7 May 2020

Antibiotic Resistance: The Patient Perspective

We discuss the impact of antibiotic-resistant infections on everyday life and the work that is being done to overcome this issue with Antibiotic Research UK.

From Bionow 6 May 2020