Fatty Liver News and Research

Latest Fatty Liver News and Research

New project aims to estimate scientific basis of health risks posed by substance mixtures

The BfR is involved with two work groups in the project, which is being coordinated by the Dutch National Institute for Public Health and the Environment

1 Nov 2018

Forced expression of a natural protein reduces fat in mice by a third

In a mouse model of obesity, forced expression of the protein FGFBP3 (BP3 for short) significantly reduced the animals’ fat mass.

29 Oct 2018

Natural protein may offer novel therapy to reverse disorders associated with metabolic syndrome

To the great surprise of cancer researchers, a protein they investigated for its possible role in cancer turned out to be a powerful regulator of metabolism.

29 Oct 2018

Novartis enters into clinical development agreement with Pfizer to improve treatment of NASH

Novartis announced today that it has entered into a clinical development agreement with Pfizer which will include a study combining tropifexor and one or more Pfizer compounds for the treatment of NASH, including an Acetyl CoA-Carboxylase (ACC) Inhibitor (PF-05221304, a Diacylglycerol O-Acyltransferase 2 (DGAT2) Inhibitor (PF-06865571, and a Ketohexokinase (KHK) Inhibitor (PF-06835919).

29 Oct 2018

Researchers identify new potential target to inhibit progression of liver disease

Naglaa Shoukry, Ph. D., and her team have made a significant breakthrough in their research aiming to limit the progression of liver disease.

26 Oct 2018

Map of human liver cells reveals molecular make-up of individual cells

A map of the cells in the human liver has been created by University Health Network Transplant Program and University of Toronto researchers, revealing for the first time differences between individual cells at the molecular level which can have a profound impact on their behaviour in tissue, tumours and disease.

From 10x Genomics, Inc. 23 Oct 2018

UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery

UT Southwestern biochemist Dr. Zhijian "James" Chen today was named winner of the prestigious 2019 Breakthrough Prize in Life Sciences for his discovery of the cGAS enzyme that launches the body's immune defense against infections and cancers.

19 Oct 2018

Sleeping Beauty technique helps identify genes responsible for NAFLD-associated liver cancer

With an estimated twenty-thousand protein-coding genes in the human genome, pinpointing a specific gene or pathway responsible for a particular disease can be like finding a needle in the proverbial haystack.

17 Oct 2018

Low levels of cellular copper may make fat cells fatter

In studies of mouse cells, Johns Hopkins researchers have found that low levels of cellular copper appear to make fat cells fatter by altering how cells process their main metabolic fuels, such as fat and sugar.

11 Oct 2018

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

Carnegie's Department of Embryology scientist Steven Farber and team have been awarded a 5-year $3.3-million NIH grant to identify novel pharmaceuticals for combatting a host of diseases associated with altered levels of lipoproteins like LDL ("bad cholesterol").

11 Oct 2018

University of Houston biologist explores therapeutic targets to prevent atherosclerosis

University of Houston biologist Michihisa Umetani, having discovered that a certain protein partnership acts to rapidly signal molecules inside blood vessels that danger is upon them, has been awarded $382,500 by the National Institutes of Health.

10 Oct 2018

Study examines link between alcohol consumption and death risk in patients with NAFLD

Non-Alcoholic Fatty Liver Disease, which is not caused by significant alcohol consumption, has become the most common liver disease in the United States and comprises more than two thirds of patients with chronic liver disease.

3 Oct 2018

Liver transplant and weight-loss surgery combination offers long-term benefits to obese patients

Obese patients who underwent a life-saving liver transplant and weight-loss surgery at the same time were better able to keep the weight off long term and had fewer metabolic complications than those who lost weight on their own before undergoing a liver transplant, Mayo Clinic research shows.

3 Oct 2018

Novel method achieves accurate and precise temperature estimation in fat-containing tissues

Magnetic resonance thermometry is the only imaging technique that noninvasively provides temperature distribution in vivo. The water proton resonance frequency shift -based method is the most popular choice for MR temperature monitoring in aqueous tissues.

20 Sep 2018

New studies examine links between fatty liver disease and mitochondrial dysfunction

Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.

17 Sep 2018

Caspase-2 enzyme inhibitor could provide effective way to stop aggressive fatty liver disease

Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis, a chronic and aggressive liver condition.

14 Sep 2018

Cellular environment affects type of tumor development

Liver cancer is the second leading cause of cancer death worldwide. Two different forms of primary liver cancer cover the majority of cases: About 10 to 20 percent of those affected develop a bile duct carcinoma within the liver (intrahepatic cholangiocellular carcinoma; ICC), the far higher proportion of liver cancers are hepatocellular carcinomas.

12 Sep 2018

New test to predict advanced fibrosis in people with NAFLD

A new test may soon be available to predict advanced fibrosis in people with non-alcoholic fatty liver disease.

12 Sep 2018

Blocking RNA-silencing protein in the liver prevents obesity and diabetes in mice

Obesity and its related ailments like type 2 diabetes and fatty liver disease pose a major global health burden, but researchers report in Nature Communications that blocking an RNA-silencing protein in the livers of mice keeps the animals from getting fat and diabetic conditions.

11 Sep 2018

Losing a single night's sleep may increase risk of metabolic diseases

Losing a single night's sleep may affect the liver's ability to produce glucose and process insulin, increasing the risk of metabolic diseases such as hepatic steatosis (fatty liver) and type 2 diabetes.

5 Sep 2018

Fatty Liver News and Research

Latest Fatty Liver News and Research

New project aims to estimate scientific basis of health risks posed by substance mixtures

Forced expression of a natural protein reduces fat in mice by a third

Natural protein may offer novel therapy to reverse disorders associated with metabolic syndrome

Novartis enters into clinical development agreement with Pfizer to improve treatment of NASH

Researchers identify new potential target to inhibit progression of liver disease

Map of human liver cells reveals molecular make-up of individual cells

UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery

Sleeping Beauty technique helps identify genes responsible for NAFLD-associated liver cancer

Low levels of cellular copper may make fat cells fatter

Carnegie scientist awarded NIH grant to identify novel medicines for cardiovascular disease

University of Houston biologist explores therapeutic targets to prevent atherosclerosis

Study examines link between alcohol consumption and death risk in patients with NAFLD

Liver transplant and weight-loss surgery combination offers long-term benefits to obese patients

Novel method achieves accurate and precise temperature estimation in fat-containing tissues

New studies examine links between fatty liver disease and mitochondrial dysfunction

Caspase-2 enzyme inhibitor could provide effective way to stop aggressive fatty liver disease

Cellular environment affects type of tumor development

New test to predict advanced fibrosis in people with NAFLD

Blocking RNA-silencing protein in the liver prevents obesity and diabetes in mice

Losing a single night's sleep may increase risk of metabolic diseases

Innovation in neuroscience drug discovery - eBook eBook

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

Fatty Liver News and Research

Latest Fatty Liver News and Research

Innovation in neuroscience drug discovery - eBook eBook

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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