Fatty Liver

Fatty liver, also known as fatty liver disease (FLD), is a reversible condition where large vacuoles of triglyceride fat accumulate in liver cells via the process of steatosis (i.e. abnormal retention of lipids within a cell).

What is Fatty Liver?

Fatty liver is a very common disorder and up to 20 percent of adults and approximately 5 percent of children are affected.

Fatty Liver Pathology

Fatty Liver Diagnosis

Acute Fatty Liver of Pregnancy Treatment

MASLD in children linked to increased mortality and chronic complications

Researchers from University of California San Diego have found that children diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD) are at significantly increased risk of premature death and serious long-term health complications.

28 Apr 2025

Researchers pioneer method to measure liver tissue stiffness without damage

Researchers in South Korea have developed an organoid disease model and non-destructive stiffness analysis technology for evaluating the efficacy of new drugs for fatty liver disease.

25 Apr 2025

DT-109 shows promise in treating atherosclerosis and liver disease

A drug candidate, previously successful at treating severe fatty liver disease, reduces atherosclerosis - a primary driver of cardiovascular death worldwide - in large mammals, a study suggests.

23 Apr 2025

Interferon regulatory factor 8 identified as key driver of liver fat buildup in NAFLD

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance. Interferon regulatory factor 8 (IRF8) is well known for its roles in immune cell differentiation and tumor pathogenesis; however, its role in regulating glucose homeostasis and lipid metabolism remains unclear.

22 Apr 2025

Plastic additives found in 85% of foods raise concern for infant health

Researchers assessed plasticizer levels in foods typical of the Spanish diet and found widespread contamination, with infants showing the highest exposure. Certain additives, like DEHP, exceeded safety thresholds in high-exposure scenarios.

21 Apr 2025

Mitochondrial pyruvate carrier structure solved after fifty years

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a process vital to all life on Earth.

18 Apr 2025

Multi-omics analysis uncovers molecular drivers of non-viral liver cancer development

Researchers discover that inflammation and aging contribute to non-viral liver cancer development. Green tea's role in reversing some of the pathway dysregulation that may contribute to the cancer development and other therapies explored.

15 Apr 2025

Sleep fragmentation in diabetes triggers lasting liver damage and cardiovascular risk

This new article publication from Acta Pharmaceutica Sinica B, discusses how diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4.

14 Apr 2025

Simple changes in eating habits could help fight obesity

Obesity is linked to numerous health complications, including diabetes, cardiovascular disease, and fatty liver disease.

25 Mar 2025

Fatty liver disease linked to higher mortality risk from many common diseases

A comprehensive study from Karolinska Institutet shows that people with fatty liver disease have almost twice the mortality rate of the general population.

24 Mar 2025

Sticking to Life’s Essential 8 slashes cancer risk, major study shows

Long-term adherence to the American Heart Association’s “Life’s Essential 8” lifestyle score significantly reduces the risk of overall and site-specific cancers. Stable high LE8 scores over four years were linked to notably lower risks of lung, breast, liver, and colorectal cancers in a large Chinese cohort study.

23 Mar 2025

Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.

14 Mar 2025

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis to more severe forms, including metabolic dysfunction-associated steatohepatitis (MASH), which may progress to fibrosis, cirrhosis, and even liver cancer.

11 Mar 2025

Asah1 gene plays key role in preventing progression of nonalcoholic fatty liver disease

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid homeostasis and cellular maintenance processes.

6 Mar 2025

Review sheds light on the mechanistic role of long non-coding RNAs in liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a global health challenge, affecting nearly 30% of adults worldwide.

28 Feb 2025

Understanding the impact of SLC transporters on liver disease progression

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

28 Feb 2025

Study unravels the link between colorectal cancer risk and steatotic liver disease

Alcoholic and non-alcoholic fatty liver disease (NAFLD) are well-known risk factors for colorectal cancer (CRC).

27 Feb 2025

Vitamin E significantly improves liver health in MASH patients, new study finds

A 96-week clinical trial found that 300 mg of Vitamin E significantly improved liver histology and reduced inflammation in patients with MASH, with no major safety concerns reported.

19 Feb 2025

Study connects loneliness and social isolation to non-alcoholic fatty liver disease risk

Loneliness and social isolation have been linked to an elevated risk of non-alcoholic fatty liver disease (NAFLD), according to a groundbreaking study conducted by researchers from Central South University and the Army Medical University in China, in collaboration with the Karolinska Institutet in Sweden.

12 Feb 2025

Could a common sugar in processed foods be fueling childhood liver disease?

Researchers found that high fructose intake, especially from processed foods, is linked to metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity, with potential misreporting of sugary food sources.

12 Feb 2025

Fatty Liver

Overview

Fatty Liver Pathology

Fatty Liver Diagnosis

Acute Fatty Liver of Pregnancy Treatment

Latest Fatty Liver News and Research

MASLD in children linked to increased mortality and chronic complications

Researchers pioneer method to measure liver tissue stiffness without damage

DT-109 shows promise in treating atherosclerosis and liver disease

Interferon regulatory factor 8 identified as key driver of liver fat buildup in NAFLD

Plastic additives found in 85% of foods raise concern for infant health

Mitochondrial pyruvate carrier structure solved after fifty years

Multi-omics analysis uncovers molecular drivers of non-viral liver cancer development

Sleep fragmentation in diabetes triggers lasting liver damage and cardiovascular risk

Simple changes in eating habits could help fight obesity

Fatty liver disease linked to higher mortality risk from many common diseases

Sticking to Life’s Essential 8 slashes cancer risk, major study shows

Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

Asah1 gene plays key role in preventing progression of nonalcoholic fatty liver disease

Review sheds light on the mechanistic role of long non-coding RNAs in liver disease

Understanding the impact of SLC transporters on liver disease progression

Study unravels the link between colorectal cancer risk and steatotic liver disease

Vitamin E significantly improves liver health in MASH patients, new study finds

Study connects loneliness and social isolation to non-alcoholic fatty liver disease risk

Could a common sugar in processed foods be fueling childhood liver disease?

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Scalable, Smart, and Accessible: The Future of Lab Automation

Fatty Liver

Overview

Latest Fatty Liver News and Research

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Scalable, Smart, and Accessible: The Future of Lab Automation

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