Lupus

Systemic lupus erythematosus (SLE), also called lupus, is an autoimmune disorder characterized by the immune system attacking the body's own tissues and organs, leading to inflammation and damage. The severity of the disease varies, from mild cases only involving the skin to severe cases affecting multiple organs, including the brain. Lupus sufferers experience flares, or intervals of active disease, and remissions in disease. The disease most predominantly occurs in women of childbearing age, but also affects children, adolescents, and men. While the cause of lupus is still unknown, various genetic, environmental, and infectious causes have been associated with its development. Current treatments for lupus vary depending on the extent of the disease, and may change over time. Some medications used to ease symptoms include nonsteroidal anti-inflammatory drugs, antimalarial drugs, corticosteroids, and immunosuppressive medications, though many of these drugs carry their own risks.
What is Lupus?

Systemic lupus erythematosus (SLE), which is more commonly referred to as lupus, is a disease that affects the immune system.

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Latest Lupus News and Research

New book guides high-risk pregnancy decisions after Dobbs

New book guides high-risk pregnancy decisions after Dobbs

Placental biology breakthrough could make biologic medicines safer during pregnancy

Placental biology breakthrough could make biologic medicines safer during pregnancy

Study shows how the immune system behaves throughout pregnancy

Study shows how the immune system behaves throughout pregnancy

Pediatric rheumatic diseases have unique genetic architecture compared to adults

Pediatric rheumatic diseases have unique genetic architecture compared to adults

Study of lung immune cells uncovers roots of autoimmune disease

Study of lung immune cells uncovers roots of autoimmune disease

Newly-discovered protein acts as off switch for human immune cells

Newly-discovered protein acts as off switch for human immune cells

Mount Sinai establishes new autoimmunity center with $5 million gift

Mount Sinai establishes new autoimmunity center with $5 million gift

Inflammatory messenger substance interferon-alpha can trigger Sjögren's syndrome

Inflammatory messenger substance interferon-alpha can trigger Sjögren's syndrome

Dysregulation of immune regulator NF-κB drives major human diseases

Dysregulation of immune regulator NF-κB drives major human diseases

Off-the-shelf CAR T therapy targets treatment-resistant systemic sclerosis

Off-the-shelf CAR T therapy targets treatment-resistant systemic sclerosis

Anti-lipid antibodies could improve early testing for Lyme disease

Anti-lipid antibodies could improve early testing for Lyme disease

Monoclonal antibody shows promise for treating acute respiratory distress syndrome

Monoclonal antibody shows promise for treating acute respiratory distress syndrome

New anti-lipid antibodies could improve diagnosis of Lyme disease

New anti-lipid antibodies could improve diagnosis of Lyme disease

HSS researchers link early-life immunity to adult immune function

HSS researchers link early-life immunity to adult immune function

Scientists find link between bacterium in the gut ecosystem and lupus

Scientists find link between bacterium in the gut ecosystem and lupus

Immune cells drive abnormal joint tissue growth in rheumatoid arthritis

Immune cells drive abnormal joint tissue growth in rheumatoid arthritis

Researchers uncover key mechanism driving chronic Sjögren disease

Researchers uncover key mechanism driving chronic Sjögren disease

Philanthropic investment expands collaborative network for autoimmune research

Philanthropic investment expands collaborative network for autoimmune research

Review finds vitamin D lacks disease-modifying effect in rheumatic diseases

Review finds vitamin D lacks disease-modifying effect in rheumatic diseases

GLP-1 therapies linked to fewer complications in adults with both obesity and autoimmune disease

GLP-1 therapies linked to fewer complications in adults with both obesity and autoimmune disease

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