Lupus

Systemic lupus erythematosus (SLE), also called lupus, is an autoimmune disorder characterized by the immune system attacking the body's own tissues and organs, leading to inflammation and damage. The severity of the disease varies, from mild cases only involving the skin to severe cases affecting multiple organs, including the brain. Lupus sufferers experience flares, or intervals of active disease, and remissions in disease. The disease most predominantly occurs in women of childbearing age, but also affects children, adolescents, and men. While the cause of lupus is still unknown, various genetic, environmental, and infectious causes have been associated with its development. Current treatments for lupus vary depending on the extent of the disease, and may change over time. Some medications used to ease symptoms include nonsteroidal anti-inflammatory drugs, antimalarial drugs, corticosteroids, and immunosuppressive medications, though many of these drugs carry their own risks.
What is Lupus?

Systemic lupus erythematosus (SLE), which is more commonly referred to as lupus, is a disease that affects the immune system.

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Overview

Feature Articles

Latest Lupus News and Research

Mutated RIG-I receptor causes kidney inflammation through Y-RNA activation

Mutated RIG-I receptor causes kidney inflammation through Y-RNA activation

First multiple sclerosis patient in the UK receives CAR T cell therapy in groundbreaking trial

First multiple sclerosis patient in the UK receives CAR T cell therapy in groundbreaking trial

Rozanolixizumab prevents congenital heart block in high-risk pregnancy

Rozanolixizumab prevents congenital heart block in high-risk pregnancy

Scientists uncover a key mechanism that protects the skin from harmful inflammation

Scientists uncover a key mechanism that protects the skin from harmful inflammation

Researchers uncover TRAT1's central role in T helper cell function

Researchers uncover TRAT1's central role in T helper cell function

SGLT-2 inhibitors offer protection against autoimmune conditions

SGLT-2 inhibitors offer protection against autoimmune conditions

How shifting antibodies fuel aging and the new therapies aiming to slow it

How shifting antibodies fuel aging and the new therapies aiming to slow it

X-HiDE project advances toward earlier detection and precision treatment of inflammatory diseases

X-HiDE project advances toward earlier detection and precision treatment of inflammatory diseases

Engineered CAR-NK cells show enhanced cancer killing and immune evasion

Engineered CAR-NK cells show enhanced cancer killing and immune evasion

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

A universal solution emerges: Anti-linker antibodies simplify CAR-T detection and development

A universal solution emerges: Anti-linker antibodies simplify CAR-T detection and development

Understanding how mRNA stability influences immune diseases

Understanding how mRNA stability influences immune diseases

New guidelines for managing interstitial lung disease associated with connective tissue diseases

New guidelines for managing interstitial lung disease associated with connective tissue diseases

New protein-based therapeutic tool could change the way we treat diseases

New protein-based therapeutic tool could change the way we treat diseases

Researchers reveal how diseases interact at the genetic level

Researchers reveal how diseases interact at the genetic level

Glycosylation emerges as a key player in kidney disease progression

Glycosylation emerges as a key player in kidney disease progression

Antibiotics in pregnancy and infancy do not raise autoimmune disease risk in children

Antibiotics in pregnancy and infancy do not raise autoimmune disease risk in children

New core dataset advances standardized care and research in systemic lupus erythematosus

New core dataset advances standardized care and research in systemic lupus erythematosus

Johns Hopkins team develops a more reliable AI for early cancer detection

Johns Hopkins team develops a more reliable AI for early cancer detection

New nanoparticle drug delivery system targets the spleen for precise lupus treatment

New nanoparticle drug delivery system targets the spleen for precise lupus treatment

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