Lupus

Systemic lupus erythematosus (SLE), also called lupus, is an autoimmune disorder characterized by the immune system attacking the body's own tissues and organs, leading to inflammation and damage. The severity of the disease varies, from mild cases only involving the skin to severe cases affecting multiple organs, including the brain. Lupus sufferers experience flares, or intervals of active disease, and remissions in disease. The disease most predominantly occurs in women of childbearing age, but also affects children, adolescents, and men. While the cause of lupus is still unknown, various genetic, environmental, and infectious causes have been associated with its development. Current treatments for lupus vary depending on the extent of the disease, and may change over time. Some medications used to ease symptoms include nonsteroidal anti-inflammatory drugs, antimalarial drugs, corticosteroids, and immunosuppressive medications, though many of these drugs carry their own risks.
What is Lupus?

Systemic lupus erythematosus (SLE), which is more commonly referred to as lupus, is a disease that affects the immune system.

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Overview

Feature Articles

Latest Lupus News and Research

Novel peptide PEPITEM shows promise in fighting 'inflammaging'

Novel peptide PEPITEM shows promise in fighting 'inflammaging'

Tulane University leads effort in sex-based precision medicine with NIH grant

Tulane University leads effort in sex-based precision medicine with NIH grant

Scientists discover a molecular defect that promotes pathologic immune response in lupus

Scientists discover a molecular defect that promotes pathologic immune response in lupus

Chronic exposure to air pollutants may increase lupus risk, research shows

Chronic exposure to air pollutants may increase lupus risk, research shows

Breakthrough humanized mouse model offers new insights for immunotherapy development

Breakthrough humanized mouse model offers new insights for immunotherapy development

Researchers discover role of particular protein in the development of lupus

Researchers discover role of particular protein in the development of lupus

Innovative CAR T cell therapy shows promise for relapsed CIDP patients

Innovative CAR T cell therapy shows promise for relapsed CIDP patients

Study reveals doubling of chronic hypertension in pregnancy from 2008 to 2021 in the U. S.

Study reveals doubling of chronic hypertension in pregnancy from 2008 to 2021 in the U. S.

New insights into predictors of organ damage in childhood-onset SLE

New insights into predictors of organ damage in childhood-onset SLE

Mutated TREX1 gene linked to catastrophic DNA damage and deadly rare disease

Mutated TREX1 gene linked to catastrophic DNA damage and deadly rare disease

Dose reduction of glucocorticoids in systemic lupus erythematosus

Dose reduction of glucocorticoids in systemic lupus erythematosus

Genetic discovery reveals key to inflammatory diseases

Genetic discovery reveals key to inflammatory diseases

Novel technique maps enhancer-gene interactions in single cells

Novel technique maps enhancer-gene interactions in single cells

New genetic discoveries offer hope for targeted lupus therapies

New genetic discoveries offer hope for targeted lupus therapies

Hallucinations and nightmares could herald the onset of autoimmune diseases

Hallucinations and nightmares could herald the onset of autoimmune diseases

New study sheds light on interferon combinations' role in lupus variability

New study sheds light on interferon combinations' role in lupus variability

Breakthrough implantable cardiac pump offers hope for children awaiting heart transplants

Breakthrough implantable cardiac pump offers hope for children awaiting heart transplants

Personalized screening approach may better predict preeclampsia in the first trimester of pregnancy

Personalized screening approach may better predict preeclampsia in the first trimester of pregnancy

Columbia researchers uncover brain's ability to control inflammation

Columbia researchers uncover brain's ability to control inflammation

Garvan Institute and Illumina collaborate to transform the treatment of complex diseases

Garvan Institute and Illumina collaborate to transform the treatment of complex diseases

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