Lupus News and Research

Latest Lupus News and Research

Human gene maps show widespread gaps in non-European representation

Human gene maps contain major blind spots because they were built largely from the DNA sequences of people with European ancestry, according to a study published today in Nature Communications.

3 Dec 2025

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

A new paper from the University of Kansas overturns the idea that a "risk gene" carried by millions of people worldwide influences production of Type 1 interferon, a workhorse of the immune system.

25 Nov 2025

Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus

Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by Weill Cornell Medicine investigators.

24 Nov 2025

Study develops highly accurate polygenic risk models tailored for Han Chinese populations

Researchers at Academia Sinica have developed the first population-specific polygenic risk score (PRS) models for people of Han Chinese ancestry, achieving unprecedented accuracy in predicting risks for common diseases such as diabetes, heart disease, autoimmune disorders.

20 Nov 2025

Breakthrough in FcγRI inhibition opens path to safer autoimmune therapies

An international research group directed by UMC Utrecht have developed and characterized two first-in-class antibodies that specifically block the high-affinity IgG receptor FcγRI.

19 Nov 2025

New transplant approach resets the immune system to stop Type 1 diabetes

A combination blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured Type 1 diabetes in mice in a study by Stanford Medicine researchers.

18 Nov 2025

UCI Health launches clinical trial to test investigational cell therapy for lupus

UCI Health has opened a clinical trial to test an investigational cell therapy for lupus with the potential to give patients long-term remission of symptoms.

17 Nov 2025

Scientists map the genetic control system behind FOXP3 in immune cells

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues.

13 Nov 2025

Study links common Epstein-Barr virus to autoimmune lupus

One of humanity's most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus erythematosus or, colloquially, lupus, Stanford Medicine investigators and their colleagues have found.

12 Nov 2025

Mutated RIG-I receptor causes kidney inflammation through Y-RNA activation

Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction.

31 Oct 2025

First multiple sclerosis patient in the UK receives CAR T cell therapy in groundbreaking trial

A multiple sclerosis (MS) patient in the UK was the first to receive CAR T cell therapy, invented by UCL researchers, in a clinical trial testing whether this personalized treatment can slow or even halt the progression of the disease.

24 Oct 2025

Rozanolixizumab prevents congenital heart block in high-risk pregnancy

Congenital heart block, sometimes referred to as cardiac neonatal lupus, is a rare but potentially life-threatening condition that affects babies born to mothers with specific autoantibodies - called anti-SSA/Ro antibodies - which can attack the fetal heart via its electrical conduction system, leading to a slower heart rate.

22 Oct 2025

Scientists uncover a key mechanism that protects the skin from harmful inflammation

Researchers at VIB and Ghent University have uncovered a key mechanism that protects the skin from harmful inflammation.

21 Oct 2025

Researchers uncover TRAT1's central role in T helper cell function

Researchers at the Medical University of Vienna have taken a closer look at a previously largely unknown component of the immune system: the protein molecule TRAT1 (T Cell Receptor Associated Transmembrane Adaptor 1) plays a central role in how so-called T helper cells (a specialised subgroup of immune cells) distinguish between attack and self-control - an important mechanism for restraining inflammation and preventing autoimmune diseases. The findings have recently been published in the journal Cell Communication and Signaling.

16 Oct 2025

SGLT-2 inhibitors offer protection against autoimmune conditions

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors used to treat type 2 diabetes are associated with an 11% lower risk of autoimmune rheumatic diseases, such as rheumatoid arthritis and lupus, compared with another group of diabetes drugs called sulfonylureas, finds a study from South Korea published by The BMJ today.

15 Oct 2025

How shifting antibodies fuel aging and the new therapies aiming to slow it

This review uncovers how aging reshapes immunoglobulins, particularly IgG, IgM, and IgA, driving inflammation, cellular senescence, and tissue degeneration. By dissecting B-cell dysfunction, glycosylation changes, and Fc receptor pathways, it reveals immunoglobulins as both biomarkers and potential therapeutic targets in aging.

14 Oct 2025

X-HiDE project advances toward earlier detection and precision treatment of inflammatory diseases

Facilitating earlier diagnosis and more precise treatment for patients with inflammatory diseases. This is the goal as the X-HiDE research project at örebro University in Sweden now enters its next phase, in collaboration with eleven companies and four other universities in Europe and the USA.

8 Oct 2025

Engineered CAR-NK cells show enhanced cancer killing and immune evasion

One of the newest weapons that scientists have developed against cancer is a type of engineered immune cell known as CAR-NK (natural killer) cells. Similar to CAR-T cells, these cells can be programmed to attack cancer cells.

8 Oct 2025

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

Scientists have mapped underappreciated scaffolding cells in skin, known as fibroblasts. They show for the first time how fibroblasts go 'rogue' in many different diseases affecting multiple organs – from acne and psoriasis, to rheumatoid arthritis and inflammatory bowel disease.

24 Sep 2025

A universal solution emerges: Anti-linker antibodies simplify CAR-T detection and development

CAR-T cell therapy has demonstrated remarkable success in treating hematologic malignancies and is now expanding into solid tumors.

From Sino Biological Inc. 13 Sep 2025

Lupus News and Research

Latest Lupus News and Research

Human gene maps show widespread gaps in non-European representation

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus

Study develops highly accurate polygenic risk models tailored for Han Chinese populations

Breakthrough in FcγRI inhibition opens path to safer autoimmune therapies

New transplant approach resets the immune system to stop Type 1 diabetes

UCI Health launches clinical trial to test investigational cell therapy for lupus

Scientists map the genetic control system behind FOXP3 in immune cells

Study links common Epstein-Barr virus to autoimmune lupus

Mutated RIG-I receptor causes kidney inflammation through Y-RNA activation

First multiple sclerosis patient in the UK receives CAR T cell therapy in groundbreaking trial

Rozanolixizumab prevents congenital heart block in high-risk pregnancy

Scientists uncover a key mechanism that protects the skin from harmful inflammation

Researchers uncover TRAT1's central role in T helper cell function

SGLT-2 inhibitors offer protection against autoimmune conditions

How shifting antibodies fuel aging and the new therapies aiming to slow it

X-HiDE project advances toward earlier detection and precision treatment of inflammatory diseases

Engineered CAR-NK cells show enhanced cancer killing and immune evasion

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

A universal solution emerges: Anti-linker antibodies simplify CAR-T detection and development

Industry Focus eBook - Pharmaceutical manufacturing (2nd edition) eBook

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

Lupus News and Research

Latest Lupus News and Research

Industry Focus eBook - Pharmaceutical manufacturing (2nd edition) eBook

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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