Pharmacology News and Research

Latest Pharmacology News and Research

Researchers identify how immune cells triggered by recurrent Strep A infections affect the brain

Researchers have discovered how immune cells triggered by recurrent Strep A infections enter the brain, causing inflammation that may lead to autoimmune neuropsychiatric disorders in children.

16 Dec 2015

Many gene variants affect person's response to medication

In recent decades much hope was based on the development of personalised drug treatments, in which genetic tests determine the choice and optimal dose of medication for each individual patient. However, the real breakthrough is still to be seen, and now researchers at Karolinska Institutet show in two separate scientific papers that many more gene variants affect how a person responds to medication than previously thought - and thus that today's analytical tools are too coarse.

16 Dec 2015

Bile acid may help treat fatty liver disease and obesity

A bile acid that can turn off a receptor in the gut has prevented and reversed fatty liver disease in mice, according to an international team of researchers. The compound may help treat certain metabolic disorders, such as Type 2 diabetes and obesity, as well.

16 Dec 2015

VCU Massey Cancer Center scientists reveal signaling process that leads to excessive growth of cancer

The gene p53 has been described as the "guardian of the genome" due to its prominent role in preventing genetic mutations. More than half of all cancers are thought to originate from p53 mutations or loss of function, and now a recent study by VCU Massey Cancer Center scientist Richard Moran, Ph.D., explains why.

15 Dec 2015

Researchers discover novel way to enhance, restore cancer suppressor activity in B-ALL

Researchers at Penn State College of Medicine, working with Chinese and American colleagues, have discovered a novel way to enhance and restore cancer suppressor activity in B-cell acute lymphoblastic leukemia, resulting in better outcomes in a pre-clinical model of the disease. The finding could pave the way for a new class of drugs for this and other forms of leukemia.

15 Dec 2015

CAP2 gene responsible for cardiac conduction disease in mice

The presence or absence of the CAP2 gene causes sudden cardiac death in mice, according to new research from the Perelman School of Medicine at the University of Pennsylvania. In particular, the absence of the gene interrupts the animal's ability to send electrical signals to the heart to tell it to contract, a condition called cardiac conduction disease.

15 Dec 2015

Unhealthy microbiome shifts can lead to weight gain, obesity

The link between the gut microbiome and obesity seems clear, but just how changes to gut bacteria can cause weight gain is not.

14 Dec 2015

UC San Diego biologists develop a method to screen natural products for new antibiotics

Biologists at UC San Diego have found that a method they developed to identify and characterize new antibiotics can be employed to screen natural products quickly for compounds capable of controlling antibiotic resistant bacteria.

11 Dec 2015

Study: Spanish-speaking Hispanic women less likely to use neuraxial analgesia during labor

Why do Hispanic women have reduced rates of epidural or spinal (neuraxial) analgesia during labor? Language barriers may be a key factor, according to a study in Anesthesia & Analgesia.

11 Dec 2015

Penn's Brian Litt recognized with AES Research Recognition Award for Clinical Science

The American Epilepsy Society announces that Brian Litt, M.D., professor of neurology, neurosurgery and bioengineering at the University of Pennsylvania, is being honored with the AES Research Recognition Award for Clinical Science on December 7, 2015, at the Society's 69th annual meeting in Philadelphia.

8 Dec 2015

The Importance of Flexibility in Spectrophotometry

News-Medical speaks to Jessica Geisler about the need for flexible spectrophotometers that can handle a range of measurement types.

From Eppendorf 1 Dec 2015

New model of arterial thrombus formation is similar to popular video game

A group of biophysicists, including representatives from MIPT, has developed a mathematical model of arterial thrombus formation, which is the main cause of heart attacks and strokes.

1 Dec 2015

MPP collaborates with University of Liverpool to accelerate development of HIV nanomedicines

The Medicines Patent Pool today announced a collaboration with the University of Liverpool and a licence for the university's Solid Drug Nanoparticle (SDN) technology to accelerate the development of WHO-recommended antiretrovirals as nanomedicines.

30 Nov 2015

Novel anticancer agent appears to have greater potency, longer efficacy than irinotecan and topotecan

In the five decades since camptothecin was first isolated from the bark of a tree used in traditional Chinese medicine and identified as a powerful anticancer agent, several thousand chemicals with similar structures and functions have been investigated. And while two of these analog compounds, irinotecan and topotecan, have been approved in the U.S. as treatments for cancer, both are associated with significant shortcomings.

26 Nov 2015

Scientists show evidence for exchange of lactate between different brain cells

Nerve cells cover their high energy demand with glucose and lactate. Scientists of the University of Zurich now provide new support for this. They show for the first time in the intact mouse brain evidence for an exchange of lactate between different brain cells. With this study they were able to confirm a 20-year old hypothesis.

25 Nov 2015

Study suggests new approaches to fighting diseases using the power of illusion

Magic tricks work because they take advantage of the brain's sensory assumptions, tricking audiences into seeing phantoms or overlooking sleights of hand. Now a team of UC San Francisco researchers has discovered that even brainless single-celled yeast have sensory biases that can be hacked by a carefully engineered illusion, a finding that could be used to develop new approaches to fighting diseases such as cancer.

20 Nov 2015

Simple blood test may predict speed of recovery from postoperative pain and dysfunction

A simple blood test taken before surgery may predict how quickly patients recover from their procedure, suggests a new study in the December issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists.

20 Nov 2015

Scientists identify way to sensitize drug-resistant glioblastoma cells to chemotherapy

Scientists from the Virginia Tech Carilion Research Institute and clinicians from Carilion Clinic have discovered how to sensitize drug-resistant human glioblastoma cells to chemotherapy.

20 Nov 2015

Sildenafil drug improves insulin sensitivity in people at risk for diabetes

The drug sildenafil, sold as Viagra and other brand names, improves insulin sensitivity in people at risk for diabetes, researchers at Vanderbilt University Medical Center reported today.

19 Nov 2015

UCLA researchers find new way to reduce ascites with minimal side effects

Women who have ovarian cancer often develop a condition called ascites, which is a buildup of fluids in the abdomen. The most common treatment for ascites is puncturing the abdomen and manually draining the fluid, which is painful and risky and must be repeated every few weeks.

18 Nov 2015

Pharmacology News and Research

Latest Pharmacology News and Research

Researchers identify how immune cells triggered by recurrent Strep A infections affect the brain

Many gene variants affect person's response to medication

Bile acid may help treat fatty liver disease and obesity

VCU Massey Cancer Center scientists reveal signaling process that leads to excessive growth of cancer

Researchers discover novel way to enhance, restore cancer suppressor activity in B-ALL

CAP2 gene responsible for cardiac conduction disease in mice

Unhealthy microbiome shifts can lead to weight gain, obesity

UC San Diego biologists develop a method to screen natural products for new antibiotics

Study: Spanish-speaking Hispanic women less likely to use neuraxial analgesia during labor

Penn's Brian Litt recognized with AES Research Recognition Award for Clinical Science

The Importance of Flexibility in Spectrophotometry

New model of arterial thrombus formation is similar to popular video game

MPP collaborates with University of Liverpool to accelerate development of HIV nanomedicines

Novel anticancer agent appears to have greater potency, longer efficacy than irinotecan and topotecan

Scientists show evidence for exchange of lactate between different brain cells

Study suggests new approaches to fighting diseases using the power of illusion

Simple blood test may predict speed of recovery from postoperative pain and dysfunction

Scientists identify way to sensitize drug-resistant glioblastoma cells to chemotherapy

Sildenafil drug improves insulin sensitivity in people at risk for diabetes

UCLA researchers find new way to reduce ascites with minimal side effects

Industry Focus eBook - Pharmaceutical manufacturing (2nd edition) eBook

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

Pharmacology News and Research

Latest Pharmacology News and Research

Industry Focus eBook - Pharmaceutical manufacturing (2nd edition) eBook

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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