Pharmacology News and Research

Latest Pharmacology News and Research

Experts release new guidelines on JAK inhibitors for chronic inflammatory diseases

Janus kinase inhibitors (JAKis) are an important treatment option for people with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis.

17 Mar 2025

Scientist whose work led FDA to ban food dye says agency overstated risk

When the FDA announced in January, before President Joe Biden's term ended, that it would ban a dye called red dye No. 3 in food and ingested drugs, the federal agency cited just one 1987 study on rats to support its action.

17 Mar 2025

Nanogels can improve antibiotic delivery for urinary tract infections

Researchers from the University of Colorado Anschutz Medical Campus studied a new method to deliver antibiotics, specifically gentamicin, directly into the bladder tissue to better treat UTIs.

12 Mar 2025

Breakthrough drug combination targets KRAS mutation in lung cancer

A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have uncovered a powerful combination therapy leveraging sotorasib-an FDA-approved drug in the market-and an experimental drug called FGTI-2734, which could make precision medicine more effective for patients with a highly resistant form of lung cancer.

10 Mar 2025

Diabetes changes the biology of breast cancer, study shows

More than 120 million Americans suffer from diabetes or pre-diabetes. Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and TNBC patients with obesity-driven diabetes often have worse outcomes.

6 Mar 2025

Melatonin protects skeletal muscle from damage caused by "diabesity"

An international study led by the University of Granada (UGR) has revealed that melatonin, known for its ability to regulate the sleep/wake cycle, can restore the composition of muscle fibers and protect skeletal muscle from damage caused by obesity and type 2 diabetes, known as "diabesity".

5 Mar 2025

New three-organ system offers an animal-free alternative for pharmacokinetics research

Innovative organ-on-chip specialist Dynamic42 and ESQlabs, experts in digital life sciences solutions, have successfully developed a three-organ system, in close collaboration with Consumer Health Division of Bayer, and the Placenta Lab at Jena University Hospital.

2 Mar 2025

Scientists develop fenugreek-based nanoparticles to enhance diabetes drug effectiveness

Researchers explored L-arginine-loaded lipid nanoparticles from fenugreek seed oil, finding they enhance drug stability and bioavailability, showing promise for diabetes treatment.

2 Mar 2025

New study identifies brain circuit key to reducing cocaine-seeking behavior

Imagine a future where the grip of cocaine use disorder can be loosened, where cravings fade, and the risk of relapse diminishes.

27 Feb 2025

Review: Artificial intelligence is shaping the future of diabetes care

The global incidence and prevalence of diabetes continue to rise, increasing rates of associated disability and mortality while imposing a substantial economic burden.

26 Feb 2025

Genetic study demonstrates fat-selective weight loss with GLP-1 agonist use

Diabetes and obesity have become pressing health issues worldwide. Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications widely used in the treatment of type 2 diabetes (T2D), have shown significant effectiveness in both lowering blood sugar levels and aiding weight loss due to their unique pharmacological mechanisms.

25 Feb 2025

Considerations for taking ASO discovery programs into animal models

ALS therapy can be drastically advanced with the help of ASOs.

From Charles River Labs - Neuroscience Discovery Services 24 Feb 2025

Antioxidant-enzyme interactions and their role in non-communicable diseases

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role in the development of non-communicable diseases (NCDs).

21 Feb 2025

Younger people more susceptible to nicotine addiction than middle-aged adults

People in their late teens and early 20s may be more sensitive to nicotine and more susceptible to nicotine addiction than middle aged adults, according to a new study in mice from researchers in the Penn State Department of Biobehavioral Health.

20 Feb 2025

Survey reveals public enthusiasm for personalizing medicine with genetic data

Pharmacogenomics – an individual's genetic response to medications – is an increasingly important strand of personalised healthcare but little is known about the public's views on it.

20 Feb 2025

Exploring ketamine's potential in the fight against treatment-resistant depression

Major depressive disorder (MDD) is a leading cause of disability worldwide, with a significant proportion of patients (10-20%) progressing to treatment-resistant depression (TRD).

19 Feb 2025

Nanotechnology offers new hope for treating Neglected Tropical Diseases

Neglected Tropical Diseases (NTDs) remain a significant health burden in tropical and subtropical regions, with limited treatment options and diagnostic capabilities.

19 Feb 2025

How can machine learning accelerate neuroscience behavior studies?

Thanks to its capacity to detect patterns and stay consistent, machine learning is a great tool for CNS behaviour studies.

From Charles River Labs - Neuroscience Discovery Services 18 Feb 2025

Gene therapy shows promise in treating SCN1B-linked epileptic encephalopathies

Dravet syndrome and other developmental epileptic encephalopathies are rare but devastating conditions that cause a host of symptoms in children, including seizures, intellectual disability, and even sudden death.

14 Feb 2025

Opioid δ-receptor agonists show promise for treating IBS-like symptoms

Research reveals that δ-receptor agonists like KNT-127 alleviate IBS symptoms by modulating gut-brain interactions and reducing stress-induced hypermotility.

7 Feb 2025