Pharmacology News and Research

Latest Pharmacology News and Research

Mount Sinai study provides a mechanistic explanation for variations in individual responses to drugs

Mount Sinai researchers have shown for the first time that a person's beliefs related to drugs can influence their own brain activity and behavioral responses in a way comparable to the dose-dependent effects of pharmacology.

3 Jan 2024

Yale scientists identify drug target that may alleviate joint degeneration in osteoarthritis

Yale researchers have identified a drug target that may alleviate joint degeneration associated with osteoarthritis, a debilitating condition that afflicts as many as 30 million people in the United States alone, which they report on Jan. 3 in the journal Nature.

3 Jan 2024

Calcium channel blockers reverse muscle weakness in animal model of myotonic dystrophy type 1

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these symptoms in animal models of the disease.

2 Jan 2024

Brain receptor discovery opens door to new therapies for addiction and mental health

Researchers at the Icahn School of Medicine at Mount Sinai have uncovered insights into the potential mechanism of action of the antipsychotic medication asenapine, a possible therapeutic target for substance use and neuropsychiatric disorders.

2 Jan 2024

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

22 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Scientists design non-hallucinogenic psychedelic treatments potentially accelerating research on mental health benefits

Researchers identified 5-hydroxytryptamine 2A (5-HT2A) receptor (5-HT2AR) signaling pathways associated with psychedelic potential.

19 Dec 2023

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Amidst a backdrop of industry-wide hurdles like inflation, talent scarcities, and stringent regulatory landscapes, Nona Biosciences is showing great promise as an emerging global leader in biotechnology.

From Nona BioSciences 19 Dec 2023

Paternal alcohol consumption prior to conception can have a negative effect on fetal development

Researchers at Texas A&M University have already shown that paternal drinking habits prior to conception can have a negative effect on fetal development -; with semen from men who regularly consume alcohol impacting placenta development, fetal alcohol syndrome (FAS)-associated brain and facial defects, and even IVF outcomes.

13 Dec 2023

Study cautions against using QbTest as a standalone tool for diagnosing ADHD

A new study cautions against using the QbTest as a standalone diagnostic or screening tool for ADHD.

13 Dec 2023

Novel molecular link between vitamin B12 and multiple sclerosis revealed in astrocytes

For decades, scientists have noted an intriguing similarity between a deficiency in vitamin B12 – an essential nutrient that supports healthy development and functioning of the central nervous system (CNS) – and multiple sclerosis (MS), a chronic disease in which the body's immune system attacks the CNS and which can produce neurodegeneration.

11 Dec 2023

New drug combo shows promise in targeting RAS-mutant multiple myeloma

The combination of a drug and a protein fragment prevents the growth of blood cancer cells, a new study in mice shows.

11 Dec 2023

Study offers new hope for heart repair and regeneration with reduced mitochondrial activity

USF Health Heart Institute doctors are upbeat about cardiac regeneration. But when those batteries – heart muscle cells called cardiomyocytes − short circuit and die, the damage can be devastating.

8 Dec 2023

Vanderbilt's potential schizophrenia treatment enters phase 1 clinical trials

A potential schizophrenia treatment discovered through the Warren Center for Neuroscience Drug Discovery has been cleared by the U.S. Food and Drug Administration for use in phase 1 clinical trials-;the third WCNDD therapeutic to reach that benchmark.

7 Dec 2023

MedUni Vienna scientists discover new pain medication with fewer side effects

People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects.

6 Dec 2023

Research uncovers stealthy strategy of SARS-CoV-2 infection

Researchers have discovered a novel mechanism whereby the SARS-CoV-2 virus, which causes COVID-19, can vary its mode of infection in human cells. Published in the journal eLife, a team from the University of Minnesota and the Midwest Antiviral Drug Discovery (AViDD) Center found the virus can alternate between being highly infectious and avoiding detection by the immune system.

5 Dec 2023

Pharmacology News and Research

Latest Pharmacology News and Research

Mount Sinai study provides a mechanistic explanation for variations in individual responses to drugs

Yale scientists identify drug target that may alleviate joint degeneration in osteoarthritis

Calcium channel blockers reverse muscle weakness in animal model of myotonic dystrophy type 1

Brain receptor discovery opens door to new therapies for addiction and mental health

St. Jude researchers crack the code of the β2-adrenergic receptor

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Scientists design non-hallucinogenic psychedelic treatments potentially accelerating research on mental health benefits

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Paternal alcohol consumption prior to conception can have a negative effect on fetal development

Study cautions against using QbTest as a standalone tool for diagnosing ADHD

Novel molecular link between vitamin B12 and multiple sclerosis revealed in astrocytes

New drug combo shows promise in targeting RAS-mutant multiple myeloma

Study offers new hope for heart repair and regeneration with reduced mitochondrial activity

Vanderbilt's potential schizophrenia treatment enters phase 1 clinical trials

MedUni Vienna scientists discover new pain medication with fewer side effects

Research uncovers stealthy strategy of SARS-CoV-2 infection

Scientists uncover dopamine's role in learning from rewards and punishments

Brain peptide identified as key player in heavy alcohol drinking

Silencing galectin 1 protein shrinks liver cancer tumors in mice

Latest scientific findings provide new insights into heart and stroke health

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Pharmacology News and Research

Latest Pharmacology News and Research

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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