T Cell News and Research

Latest T Cell News and Research

Sulforaphane prolongs lifespan and healthspan of C. elegans through insulin/IGF-1 signaling

Aging-US published "Sulforaphane promotes C. elegans longevity and healthspan via DAF- 16/DAF-2 insulin/IGF-1 signaling" which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear.

4 Feb 2021

Novel quantum sensor offers a new route to early diagnosis, preventive treatment

Oxygen is essential for human life, but within the body, certain biological environmental conditions can transform oxygen into aggressively reactive molecules called reactive oxygen species (ROS), which can damage DNA, RNA, and proteins.

4 Feb 2021

Chronic hypoxia upregulates RNA polymerase I, alters methylation on ribosomal RNAs

Hypoxia -- where a tissue is deprived of an adequate supply of oxygen -- is a feature inside solid cancer tumors that renders them highly invasive and resistant to treatment. Study of how cells adapt to this critical stressor, by altering their metabolism to survive in a low-oxygen environment, is important to better understand tumor growth and spread.

4 Feb 2021

Study shows how tissue damage promotes the earliest stages of pancreatic cancer

Like weeds sprouting from cracks in the pavement, cancer often forms in sites of tissue damage. That damage could be an infection, a physical wound, or some type of inflammation.

4 Feb 2021

New molecular voltage sensor helps observe propagation of electrical signals in neurons

A type of novel molecular voltage sensor makes it possible to watch nerve cells at work. The principle of the method has been known for some time. However, researchers at the University of Bonn and the University of California in Los Angeles have now succeeded in significantly improving it.

4 Feb 2021

Predicting future mamalian hosts of SARS-CoV-2

Researchers at the Beijing Computational Science Research Center and Peking University analyzed sequences of the angiotensin-converting enzyme 2 (ACE2) proteins from 16 mammals and predicted the structures of ACE2- receptor-binding domain (RBD) complexes.

4 Feb 2021

Hematological findings in Amazonian patients with COVID-19

To discriminate between patients with severe and non-severe COVID-19 quickly, researchers from Peru looked for prognostic signatures in the blood samples of COVID-19 patients. Virgilio E. Failoc-Rojas et al. examined laboratory results and clinical prognosis of COVID-19 patients from a hospital in the Peruvian Amazon.

3 Feb 2021

Nasodine antiseptic nasal spray shows potential antiviral activity against SARS-CoV-2

A team of international scientists has recently investigated the efficacy of PVP-1, a complex of polyvinylpyrrolidone and iodine, in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Using in vitro cell culture settings, the scientists observe that PVP-1 formulation used in a commercially available nasal spray (Nasodine) readily inactivates SARS-CoV-2 within a short period of time.

3 Feb 2021

Insight into role of aging in response to SARS-CoV-2 infection

Researchers at the University of California, Irvine set out to determine the differences between young people and older adults regarding their host responses against SARS-CoV-2. The team revealed that independent of disease severity, COVID-19 was linked to a significant shift in plasma inflammatory factors. The research is posted to the pre-print server medRxiv*.

3 Feb 2021

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Pompe disease is a hereditary genetic disorder caused by a deficiency of acid alpha-glucosidase leading to build-up of glycogen in the lyosomes, which then causes cell damage in various tissues, in particular the heart, the muscles, the liver and the nervous system.

3 Feb 2021

Scientists unravel the workings of a mysterious protein implicated in movement disorders

Scientists at Scripps Research have clarified the workings of a mysterious protein called Gαo, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders.

3 Feb 2021

Study gives new clues to how muscle wasting occurs on a cellular level

Muscle wasting, or the loss of muscle tissue, is a common problem for people with cancer, but the precise mechanisms have long eluded doctors and scientists. Now, a new study led by Penn State researchers gives new clues to how muscle wasting happens on a cellular level.

3 Feb 2021

Phase 1 clinical trial of novel HIV vaccine approach shows promising results

A phase 1 clinical trial testing a novel vaccine approach to prevent HIV has produced promising results, IAVI and Scripps Research announced today.

3 Feb 2021

Research could open the door to next-generation of cancer drugs that work better

Some of the most commonly used drugs for treating hereditary breast and ovarian cancers may not work the way we thought they did, according to new University of Colorado Boulder research.

3 Feb 2021

Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes

A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells.

3 Feb 2021

Experimental intranasal influenza vaccine produces durable immune response

An experimental single-dose, intranasal influenza vaccine was safe and produced a durable immune response when tested in a Phase 1 study published in the Journal of Clinical Investigation.

3 Feb 2021

Scientists receive award to explore how diet and metabolism influence the immune system

A pair of scientists from Van Andel Institute and the National Institute of Allergy and Infectious Diseases have been granted a three-year, $1.5 million Allen Distinguished Investigator award from The Paul G. Allen Frontiers Group, a division of the Allen Institute, to better understand how diet and metabolism influence the immune system's ability to fight off threats such as infections.

3 Feb 2021

Moffitt researchers reveal why some ovarian cancer patients evolve better than others

The prognosis of ovarian cancer is poor, with an estimated five-year survival of only 40% for advanced disease, the stage at which most ovarian carcinomas are diagnosed.

3 Feb 2021

CU researchers awarded NEI's 3D ROC prize to accelerate development of new therapies

Natalia Vergara, PhD, assistant professor of ophthalmology at the University of Colorado School of Medicine, has been awarded a 3D ROC prize by the National Eye Institute for her research team's work to create better models to accelerate the development of new therapies for retinal diseases.

3 Feb 2021

Two studies describe processes that affect the generation of new fat cells

Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases.

3 Feb 2021

T Cell News and Research

Latest T Cell News and Research

Sulforaphane prolongs lifespan and healthspan of C. elegans through insulin/IGF-1 signaling

Novel quantum sensor offers a new route to early diagnosis, preventive treatment

Chronic hypoxia upregulates RNA polymerase I, alters methylation on ribosomal RNAs

Study shows how tissue damage promotes the earliest stages of pancreatic cancer

New molecular voltage sensor helps observe propagation of electrical signals in neurons

Predicting future mamalian hosts of SARS-CoV-2

Hematological findings in Amazonian patients with COVID-19

Nasodine antiseptic nasal spray shows potential antiviral activity against SARS-CoV-2

Insight into role of aging in response to SARS-CoV-2 infection

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Scientists unravel the workings of a mysterious protein implicated in movement disorders

Study gives new clues to how muscle wasting occurs on a cellular level

Phase 1 clinical trial of novel HIV vaccine approach shows promising results

Research could open the door to next-generation of cancer drugs that work better

Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes

Experimental intranasal influenza vaccine produces durable immune response

Scientists receive award to explore how diet and metabolism influence the immune system

Moffitt researchers reveal why some ovarian cancer patients evolve better than others

CU researchers awarded NEI's 3D ROC prize to accelerate development of new therapies

Two studies describe processes that affect the generation of new fat cells

Immunology eBook

Transforming Lab Workflows with Cell Culture Automation

Building Bridges to Scalable Allogeneic Cell Therapy

Edoardo Fabini

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Transforming Lab Workflows with Cell Culture Automation

Building Bridges to Scalable Allogeneic Cell Therapy

Edoardo Fabini

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