T Cell News and Research

Latest T Cell News and Research

More evidence Pangolin not intermediary in transmission of SARS-CoV-2 to humans

The team proposed a different model named the ‘circulation model’ to illustrate how SARS-CoV-2-related coronaviruses could have circulated in different species, including humans, before COVID-19 emerged.

4 Oct 2020

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

In a new bioRxiv* preprint paper, researchers from the Imperial College London, King's College London, and the University of Bristol in the United Kingdom show that the furin cleavage site of SARS-CoV-2 spike glycoprotein represents a key determinant for transmission among humans, as it substantially facilitates replication in airway cells - opening the door for the development of novel therapeutics.

4 Oct 2020

Anti-sense agents suppress SARS-CoV-2 virus

Researchers in the United States have conducted a study showing that anti-sense agents called peptide-conjugated morpholino oligomers (PPMOs) have the ability to specifically and potently suppress the growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

4 Oct 2020

New, rare genetic form of dementia discovered

A new, rare genetic form of dementia has been discovered by a team of Penn Medicine researchers. This discovery also sheds light on a new pathway that leads to protein build up in the brain -- which causes this newly discovered disease, as well as related neurodegenerative diseases like Alzheimer's Disease -- that could be targeted for new therapies.

1 Oct 2020

Study offers explanation for why people's responses to the same drug vary widely

Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.

1 Oct 2020

Direction and type of the force acting on a cell can alter gene expression

Tissues and cells in the human body are subjected to a constant push and pull - strained by other cells, blood pressure and fluid flow, to name a few.

1 Oct 2020

Fecal microbiota transplantation restores gut microbial development in cesarean-born infants

The human gut contains a diverse ecosystem of microbes: mainly bacteria, as well as viruses and fungi, termed the gut microbiota. Recent years have shown that the gut microbiota have widespread effects on the overall functioning of the host's body.

1 Oct 2020

Scientists map genetic networks that control the biology of regulatory T cells

Unlike most T cells, which launch immune responses against foreign molecules, regulatory T cells are the peacekeepers of the human immune system, damping down inflammatory reactions when they're not needed.

1 Oct 2020

$9.1 million NCI grant renewal will support researchers studying retrovirus cancer models

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and The Ohio State University College of Veterinary Medicine have been awarded a five-year, $9.1 million grant Program Project Grant renewal from the National Cancer Institute.

1 Oct 2020

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

The U.S. Food and Drug Administration has granted Fast Track designation to a novel "switchable" CAR-T cell therapy developed by Calibr, a division of Scripps Research, in a move to accelerate the drug development and review process.

1 Oct 2020

Compounds repurposed from malaria treatment can kill diarrheal pathogen

A class of compounds used for malaria treatment also kill the intestinal parasite Cryptosporidium, a leading cause of diarrheal disease and death in children that has no cure, a multi-institution collaboration of researchers found in a new study.

1 Oct 2020

Study reveals how ILCs develop, adapt, specialize in specific tissue environments

Specialized immune cells settle permanently in various tissues of the body and build "local task forces". Scientists from Würzburg have now discovered, how these cell populations can renew locally and can adapt to their specific environment.

1 Oct 2020

Researchers identify pathogen responsible for creeping migration of fat in Crohn's patients

In many patients with Crohn's disease, abdominal fat migrates to the wall of the inflamed small intestines. What prompts the fat tissue to "creep" through the abdomen and wrap around the intestines of many patients with this inflammatory bowel disease (IBD) has been an enduring mystery.

1 Oct 2020

New upgrade to PET scanners may pave way for better cancer treatment

Experts in Japan have devised a simple way to glean more detailed information out of standard medical imaging scans.

1 Oct 2020

Researchers identify 'social cells' in the brain linked to social behavior

A research team led by Professor TAKUMI Toru of Kobe University's Graduate School of Medicine (also a Senior Visiting Scientist at RIKEN Center for Biosystems Dynamics Research) have identified 'social cells' in the brain that are related to social behavior. The cells were identified via Ca imaging conducted using a microendoscope .

1 Oct 2020

Study shows how cancer cells gain access to nerve signal to enter the bloodstream

Tumors come in many shapes and forms--curable or deadly, solid or liquid, lodged inside the brain, bone, or other tissues. One thing they all have in common, however, is a knack for molecular deceit.

1 Oct 2020

Immunotherapy drug improves survival over standard chemotherapy for lung cancer patients

The immunotherapy drug atezolizumab improves survival over standard chemotherapy for many patients with newly diagnosed non-small cell lung cancer (NSCLC), according to a new study led by Yale Cancer Center (YCC) researchers.

1 Oct 2020

Researchers identify a potential target for small cell lung cancer

The cover for issue 39 of Oncotarget features Figure 4, "Apoptosis assay of NRXN1-targeted ADC at IC50 dose calculated by growth inhibition curves," by Yotsumoto, et al. which reported that the authors identified transmembrane proteins overexpressed specifically in SCLC with little or no expression in normal tissues and decided to focus on the cell adhesion molecule neurexin-1.

1 Oct 2020

Study reveals factors that increase risk of hospitalization and death in HIV patients diagnosed with COVID-19

Clinical trials are testing whether medications that treat human immunodeficiency virus (HIV) can also treat COVID-19, leading some patients with HIV to believe they might be protected against the coronavirus.

1 Oct 2020

Researchers use single-cell sequencing to identify cell types that occur in pancreatic tumors

Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and Innovation Institute, an international team of researchers have described in detail the individual cells that comprise the pancreatic cancer microenvironment, a critical step in devising new treatment options for patients with this aggressive and difficult-to-treat disease.

1 Oct 2020

T Cell News and Research

Latest T Cell News and Research

More evidence Pangolin not intermediary in transmission of SARS-CoV-2 to humans

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

Anti-sense agents suppress SARS-CoV-2 virus

New, rare genetic form of dementia discovered

Study offers explanation for why people's responses to the same drug vary widely

Direction and type of the force acting on a cell can alter gene expression

Fecal microbiota transplantation restores gut microbial development in cesarean-born infants

Scientists map genetic networks that control the biology of regulatory T cells

$9.1 million NCI grant renewal will support researchers studying retrovirus cancer models

Calibr's novel 'switchable' CAR-T cell therapy granted FDA's Fast Track designation

Compounds repurposed from malaria treatment can kill diarrheal pathogen

Study reveals how ILCs develop, adapt, specialize in specific tissue environments

Researchers identify pathogen responsible for creeping migration of fat in Crohn's patients

New upgrade to PET scanners may pave way for better cancer treatment

Researchers identify 'social cells' in the brain linked to social behavior

Study shows how cancer cells gain access to nerve signal to enter the bloodstream

Immunotherapy drug improves survival over standard chemotherapy for lung cancer patients

Researchers identify a potential target for small cell lung cancer

Study reveals factors that increase risk of hospitalization and death in HIV patients diagnosed with COVID-19

Researchers use single-cell sequencing to identify cell types that occur in pancreatic tumors

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T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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