T Cell News and Research

Latest T Cell News and Research

Proteolytic activation of the SARS-CoV-2 spike S1/S2 site

In a recent paper published on the bioRxiv preprint server, Cornell University researchers study the proteolytic activation of the SARS-CoV-2 spike sites, re-evaluating the furin cleavage.

6 Oct 2020

Two Penn Medicine researchers selected for prestigious NIH Director's Awards

Picture a future where embedded medical devices not only treat and teach patients, but learn from them. Imagine chronic pain being managed without the negative side effects of opioids. Penn Medicine researchers are working to make those scenarios a reality.

6 Oct 2020

Using virus-like particles to study SARS-CoV-2 assembly, budding, and entry

In a recent preprint paper published on the bioRxiv server, researchers from the Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, discuss their efforts to assess the 4 SARS-CoV-2 structural proteins for their ability to produce VLPs from human cells to create a competent system for BSL-2 studies of SARS-CoV-2.

6 Oct 2020

New approach to reveal high-resolution protein structural details

The number of proteins in the human body, collectively known as the proteome, is vast. Somewhere between 80,000 and 400,000 proteins circulate in our cells, tissues and organs, carrying out a broad range of duties essential for life.

6 Oct 2020

Low lymphocyte count before COVID-19 heightens death risk

Researchers at the University of Rochester Medical Center have conducted a study suggesting that having a low white blood cell count (lymphocytopenia) prior to exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be associated with an increased risk of dying from coronavirus disease 2019 (COVID-19).

6 Oct 2020

UChicago genomics researcher wins NIH Director's New Innovator Award

Oni Basu, PhD, an assistant professor of genetic medicine at the University of Chicago, has received the prestigious National Institutes of Health Director's New Innovator Award.

6 Oct 2020

Salk physician-scientist has been named an NIH Director's New Innovator for 2020

Salk Institute Assistant Professor Edward Stites has been named an NIH Director's New Innovator for 2020 as part of the National Institutes of Health's High-Risk, High-Reward Research Program.

6 Oct 2020

Optimized low‐dose drug combinations to effectively treat colorectal cancer

Chemotherapy-based cancer treatment has distressing side effects for patients and increases the risk of developing resistance to the treatment.

6 Oct 2020

Study reveals potential utility of artemisinin-based treatments against SARS-CoV-2

In a recent, methodologically robust bioRXiv preprint paper, researchers from Germany, Denmark and Hong Kong report in vitro efficacy of extracts from the sweet wormwood plant (Artemisia annua), but also artemisinin, artesunate and artemether derivatives against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Oct 2020

ACGT awards $500,000 grant to advance strategies for treating solid tumors

With a $500,000 Research Grant from Alliance for Cancer Gene Therapy, Sidi Chen, PhD, assistant professor in the Department of Genetics and Systems Biology Institute at Yale School of Medicine and member of Yale Cancer Center, will advance a versatile and highly scalable strategy he's been developing and calling MAEGI -- Multiplexed Activation of Endogenous Genes as an Immunotherapy.

6 Oct 2020

Study shows how mysterious molecular concept could be used to target diseased cells

A growing area of medicine looks at how cellular binding observed in nature - where molecules like viruses or proteins bind to specific receptors on a cell - can be mimicked to aid drug delivery.

6 Oct 2020

Study shows how amino acids are transported across liposome and cell membranes

The transport of amino acids and other molecules across the cell's membrane plays a crucial role in the metabolism of cells and, therefore, in human health.

6 Oct 2020

SARS-COV-2 traveled from China to West Africa directly or via Europe

With the onset of COVID-19, the focus of medical research has been on tracing the origin of SARS-CoV-2, which was first reported in China’s Wuhan city.

6 Oct 2020

SARS-CoV-2 and anti-COVID-19 drugs activate Kaposi sarcoma-associated herpesvirus

A new study published on the preprint server bioRxiv* aimed to investigate the impacts of COVID-19 on people with various illnesses. Specifically, the researchers at the Rockefeller Cancer Institute, and the University of Arkansas for Medical Sciences wanted to see the effects of COVID-19 on patients with cancer and other infectious diseases.

6 Oct 2020

Researchers develop new testing platform for breast cancer cells

A Purdue University team has developed a novel testing platform to evaluate how breast cancer cells respond to the recurrent stretching that occurs in the lungs during breathing.

6 Oct 2020

Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

A new study from researchers at The University of Texas MD Anderson Cancer Center has discovered that mutations found in cancers do not accumulate randomly, but are found in distinct patterns that vary based on the three-dimensional organization of the genome in the cell as well as the underlying factors causing the mutations

6 Oct 2020

CAR T cell therapy can predict treatment response in patients with large B-cell lymphoma

Researchers at The University of Texas MD Anderson Cancer Center have identified molecular and cellular characteristics of anti-CD19 CAR T cell infusion products associated with how patients with large B-cell lymphoma (LBCL) respond to treatment and develop side effects.

6 Oct 2020

IL-21 protein is a major part of immune response to chronic infections in the central nervous system

Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system.

6 Oct 2020

Study shows why antiretroviral therapy does not work in certain HIV patients

Increasingly, UPMC's chief of infectious diseases - a well-regarded expert in HIV/AIDS - is contacted by a perplexed physician describing a patient with HIV who insists they are adhering to the daily medication regimen meant to keep the virus in check, but testing says otherwise.

6 Oct 2020

Chronic illnesses promote active SARS-CoV-2 infection via suppressed mucosal immunity

A recent paper published in the preprint server medRxiv in September 2020 discusses the “clinically relevant variation in the expression of COVID-19-related genes”, which is associated with the host and environmental factors, as well as host genetic factors.

6 Oct 2020

T Cell News and Research

Latest T Cell News and Research

Proteolytic activation of the SARS-CoV-2 spike S1/S2 site

Two Penn Medicine researchers selected for prestigious NIH Director's Awards

Using virus-like particles to study SARS-CoV-2 assembly, budding, and entry

New approach to reveal high-resolution protein structural details

Low lymphocyte count before COVID-19 heightens death risk

UChicago genomics researcher wins NIH Director's New Innovator Award

Salk physician-scientist has been named an NIH Director's New Innovator for 2020

Optimized low‐dose drug combinations to effectively treat colorectal cancer

Study reveals potential utility of artemisinin-based treatments against SARS-CoV-2

ACGT awards $500,000 grant to advance strategies for treating solid tumors

Study shows how mysterious molecular concept could be used to target diseased cells

Study shows how amino acids are transported across liposome and cell membranes

SARS-COV-2 traveled from China to West Africa directly or via Europe

SARS-CoV-2 and anti-COVID-19 drugs activate Kaposi sarcoma-associated herpesvirus

Researchers develop new testing platform for breast cancer cells

Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

CAR T cell therapy can predict treatment response in patients with large B-cell lymphoma

IL-21 protein is a major part of immune response to chronic infections in the central nervous system

Study shows why antiretroviral therapy does not work in certain HIV patients

Chronic illnesses promote active SARS-CoV-2 infection via suppressed mucosal immunity

Immunology eBook

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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