Toxicology News and Research

Latest Toxicology News and Research

Older firefighters exposed to heat stress on job could be more resilient over time

Older firefighters who are chronically exposed to heat stress on the job could be more heat resilient over time. A recent study published in the December issue of the Journal of Occupational and Environmental Hygiene (JOEH) found that older firefighters may be able to tolerate more challenging or arduous work environments before they feel affected by the heat, compared to non-heat-exposed workers who would need to stop work prematurely.

9 Jan 2014

New ways to treat substance abuse, neurological diseases and mental illnesses

Researchers at the University at Buffalo have found a way to change alcohol drinking behavior in rodents, using the emerging technique of optogenetics, which uses light to stimulate neurons.

7 Jan 2014

Researchers discover novel compounds that are hundreds of times more mutagenic

Researchers at Oregon State University have discovered novel compounds produced by certain types of chemical reactions - such as those found in vehicle exhaust or grilling meat - that are hundreds of times more mutagenic than their parent compounds which are known carcinogens.

6 Jan 2014

Discovery opens new pathways for treatment of toxoplasmosis and malaria

A newly identified protein and other proteins it interacts with could become effective targets for new drugs to control the parasite that cause toxoplasmosis, researchers led by investigators at Indiana University School of Medicine have reported.

3 Jan 2014

New projects advance treatments for radiation syndrome, cardiac arrest-induced brain injury and rare blood disorder

The National Institutes of Health today has launched three pre-clinical projects to advance potential new treatments for acute radiation syndrome, brain injury following cardiac arrest and a rare blood disorder called beta thalassemia.

17 Dec 2013

Mirimus develops enhanced tools for reversible gene suppression

Over the last decades, RNA interference (RNAi) has become an indispensable tool for functional genetic studies by harnessing the power of a cell intrinsic mechanism enabling reversible gene silencing.

17 Dec 2013

Artificial sweetener sucralose has biological effects

The artificial sweetener sucralose is a biologically active compound according to an extensive review published by Taylor & Francis in the recent issue of Journal of Toxicology and Environmental Health, Part B: Critical Reviews. "Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues" authored by Susan S. Schiffman, PhD, an internationally known sweetener researcher and Kristina I. Rother, MD, MHSc, of the National Institutes of Health (NIH), summarizes the biological properties of sucralose based on hundreds of archival, peer-reviewed scientific journal publications.

13 Dec 2013

Researchers discover completely new targets for treatment of blood cancers

A particularly aggressive form of leukemia is the acute lymphoblastic leukemia (ALL). It is especially common among children and very difficult to treat. Researchers from the University of Veterinary Medicine, Vienna have now discovered completely new targets for the treatment of blood cancers.

13 Dec 2013

Z-endoxifen may provide better treatment for women with estrogen positive breast cancer

A Phase I trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe, with early evidence for anti-tumor activity, a Mayo Clinic study has found. The findings indicate that Z-endoxifen, co-developed by Mayo Clinic Cancer Center and the National Cancer Institute, may provide a new and better treatment for some women with estrogen positive breast cancer and, in particular, for those women who do not respond to tamoxifen and aromatase inhibitors.

13 Dec 2013

Computational predictive toxicology services available in SafeBridge Consultants

SafeBridge Consultants, Inc., a division of Trinity Consultants, Inc., Dallas, TX, with offices in Mountain View, CA, New York, NY, and Liverpool, UK, announces the availability of computational predictive toxicology services to the biopharmaceutical and chemical industry.

10 Dec 2013

Researchers update extensive toxicology database to track information about drugs toxic effects

Sometimes the cure can be worse than the disease. Pharmaceutical drugs are known for their potential side effects, and an important aspect of personalized medicine is to tailor therapies to individuals to reduce the chances of adverse events.

6 Dec 2013

New program to investigate link between secondhand smoke and ADHD in children

Duke Medicine has established a new research program to investigate the relationship between exposure to environmental tobacco smoke during pregnancy and childhood and attention deficit hyperactivity disorder (ADHD) in children.

6 Dec 2013

Lexicon announces top-line results from initial Phase 2 study of LX1033 for treatment of IBS-d

Lexicon Pharmaceuticals, Inc. today announced top-line results from an initial Phase 2 study exploring the use of LX1033 in diarrhea-predominant irritable bowel syndrome. LX1033 is an investigational drug that inhibits serotonin synthesis in the gastrointestinal tract. Serotonin is a neurotransmitter that has been shown to play a role in the symptoms of irritable bowel syndrome.

3 Dec 2013

New biomarkers to improve diagnostics of prostate cancer

New biomarkers will improve diagnostics of endemic diseases in future, such as prostate cancer. Their mission: to recognize the tumor earlier and classify it more precisely - thereby helping avoid unnecessary operations.

2 Dec 2013

Scientists hope to find new treatments for traumatic brain injury

In the most wide-reaching project of its kind, scientists at the University of Texas Medical Branch are expanding their research on traumatic brain injury, examining its progressive, chronic effects on the body in hopes of treating its immediate and long-term consequences. The project is funded by a three-year, $9 million grant from The Moody Foundation of Galveston.

22 Nov 2013

Stroke may be associated with smoking synthetic marijuana

Add stroke to the list of severe health hazards that may be associated with smoking synthetic marijuana, popularly known as spice or K2, a University of South Florida neurology team reports.

20 Nov 2013

Long-term use of PDE3 inhibitors can lead to increased risk for sudden cardiac death

Drugs known as PDE3 inhibitors save many lives by helping failing hearts do a better job of pumping blood. But those same medications come with a sometimes deadly cost when taken for long periods: an increased risk for sudden cardiac death.

19 Nov 2013

Novel combination anti-psoriasis therapy targets genetic abnormalities in deeper layers of the skin

A novel combination anti-psoriasis therapy has potential for superior and longer-lasting therapeutic effects than current topical treatments by targeting genetic abnormalities in deeper layers of the skin. This research is being presented at the 2013 American Association of Pharmaceutical Scientists Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in San Antonio, Nov. 10-14.

15 Nov 2013

Spirituality in teens linked with increased positive social behaviors, reduced narcissism

If the spirit is truly willing, perhaps the flesh is not so weak, after all. Increased spirituality in teens undergoing substance abuse treatment is associated with greater likelihood of abstinence (as measured by toxicology screens), increased positive social behaviors, and reduced narcissism, according to a study by researchers from The University of Akron, Case Western Reserve University (CWRU) and Baylor University.

15 Nov 2013

Dermalogix awarded SBIR Phase II grant to develop topical drug candidate for atopic dermatitis

Signum Dermalogix, Inc. announced that the National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the company a Small Business Innovation Research Phase II grant totaling $1.6 million for the development of a topical drug candidate for atopic dermatitis.

15 Nov 2013

Toxicology News and Research

Latest Toxicology News and Research

Older firefighters exposed to heat stress on job could be more resilient over time

New ways to treat substance abuse, neurological diseases and mental illnesses

Researchers discover novel compounds that are hundreds of times more mutagenic

Discovery opens new pathways for treatment of toxoplasmosis and malaria

New projects advance treatments for radiation syndrome, cardiac arrest-induced brain injury and rare blood disorder

Mirimus develops enhanced tools for reversible gene suppression

Artificial sweetener sucralose has biological effects

Researchers discover completely new targets for treatment of blood cancers

Z-endoxifen may provide better treatment for women with estrogen positive breast cancer

Computational predictive toxicology services available in SafeBridge Consultants

Researchers update extensive toxicology database to track information about drugs toxic effects

New program to investigate link between secondhand smoke and ADHD in children

Lexicon announces top-line results from initial Phase 2 study of LX1033 for treatment of IBS-d

New biomarkers to improve diagnostics of prostate cancer

Scientists hope to find new treatments for traumatic brain injury

Stroke may be associated with smoking synthetic marijuana

Long-term use of PDE3 inhibitors can lead to increased risk for sudden cardiac death

Novel combination anti-psoriasis therapy targets genetic abnormalities in deeper layers of the skin

Spirituality in teens linked with increased positive social behaviors, reduced narcissism

Dermalogix awarded SBIR Phase II grant to develop topical drug candidate for atopic dermatitis

Forensics and toxicology - Industry Focus eBook eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

Toxicology News and Research

Latest Toxicology News and Research

Forensics and toxicology - Industry Focus eBook eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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