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Does Allostery Exist in Monoclonal Antibodies?

Allosteric interaction is particularly useful in the case of therapeutic biologics.

18 Jul 2018

Intracellular Antibody-Mediated Degradation

Intracellular antibody-mediated degradation is a neutralization mechanism for viruses that have enters cells.

18 Jul 2018

What are Cytochrome P450 Enzymes?

The superfamily of proteins called cytochrome P450 (CYP) enzymes are involved in the synthesis and metabolism of a range of internal and external cellular components. These enzymes have been identified in many organisms, including animals, plants, bacteria, and even in a few viruses.

17 Jul 2018

Horizontal Gene Transfer and Antibiotic Resistance

The process of horizontal gene transfer (otherwise known as HGT) can be described as one organism acquiring the DNA of another organism.

17 Jul 2018

Long non-coding RNA (Lnc RNA)

Non-coding RNAs constitute almost 98% of the human genome. Long non-coding RNA (lnc RNA) is a large class of this family where the RNA sequences are more than 200 nucleotides long and do not encode for proteins.

17 Jul 2018

Pharmacology of CAR-T Cells

Chimeric antigen receptor (CAR)-T cells are T cells which are genetically modified by the addition of tumor-reactive chimeric antigen receptors (CARs). The T cells are the workhorses of the immune system.

16 Jul 2018

How to Analyze Cellular Necroptosis

Necroptosis is a newly characterized form of cell death that has similar properties to both apoptosis and necrosis.

10 Jul 2018

Lab-Grown Neurons

Neurons grown in the laboratory provide a novel and highly effective tool for the analysis of central nervous system disorders.

10 Jul 2018

Applications of Karl Fischer Titration

Karl Fischer (KF) titration is a redox reaction which uses the consumption of water during the reaction to measure the amount of water in a sample. It is the reference method for water determination because of its specificity, accuracy and speed of measurement. It takes place in an organic solvent.

9 Jul 2018

Necroptosis Process

A recently characterised form of cell death, called necroptosis, occurs when apoptosis cannot be carried out. The activation and subsequent stages of this pathway have been characterized during the past decade, showing that it is a form of programmed cell death, sharing very similar characteristics to both apoptosis and necrosis.

9 Jul 2018

What is the Difference Between Titration and Karl Fischer Titration?

Karl Fischer titration is a specialized type of titration, which is used to determine the water content of a product or substance.

9 Jul 2018

Quorum Sensing and Pseudomonas aeruginosa

One of the ways P. aeruginosa causes infection is through quorum sensing; a type of cell signalling pathway that initiates the production of virulence factors.

9 Jul 2018

The Dark Matter of the Genome

Only 1% of the human genome encodes proteins. The rest of the genome consists of non-coding RNA, untranslated regions, splice sites and transposable elements.

9 Jul 2018

Photoactivated Localization Microscopy (PALM)

Photoactivated Localization Microscopy (PALM) is a form of super-resolution fluorescence microscopy that is used in biological research.

5 Jul 2018

Anti-Counterfeiting Ink

Anti-counterfeiting ink is a covert security feature which uses ink that is invisible unless illuminated by a particular wavelength of light.

5 Jul 2018

Notch Signaling Pathway

Notch signalling is involved in the cell-cell communication process via influencing the patterns of gene expression and differentiation. Notch pathway maintains stem cell populations and regulates binary cell fate choice. It also plays the role of mediator during short-range cell-cell communication. During development, this evolutionary conserved pathway functions in various cell types and stages.

5 Jul 2018

Helicobacter pylori Life Cycle

Helicobacter pylori is a Gram-negative, spiral-shaped, flagellated bacterium, that colonizes the gastric mucosa.

4 Jul 2018

ChIP-Sequencing Analysis: Applications

ChIP-seq, short for chromatin immunoprecipitation sequencing, combines chromatin immunoprecipitation with real-time next generation sequencing to identify genomic binding sites that proteins such as transcription factors associate with. It is a powerful tool to explore protein−DNA interactions and the regulation of genetic events in diseases and biological pathways.

4 Jul 2018

Bioactive Peptide Applications

Bioactive peptides are small protein fragments that promote metabolic health by exerting a positive influence on biological responses within the body.

4 Jul 2018

Clostridium botulinum Life Cycle

Clostridium botulinum is a relatively large, Gram-positive, spore-forming rod bacterium that grows best in an anaerobic environment at around pH 5 and produces a potent neurotoxin.

4 Jul 2018