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Flavonoids help regulate gut hormones and show promise in managing type 2 diabetes

Flavonoids show promise in treating type 2 diabetes mellitus by targeting the enteroendocrine system and regulating key gut hormones. They enhance insulin sensitivity, reduce oxidative stress, and influence appetite, glucose uptake, and hormone secretion.

26 Mar 2025

Researchers identify key gene linked to heroin addiction

Opioid use disorder is associated with more than 350,000 deaths annually worldwide. Guided by the need for an increased understanding of critical neurobiological features of addiction, researchers have now found a unique molecular signature and genes in the orbitofrontal cortex associated with heroin-seeking behavior.

26 Mar 2025

Cedars-Sinai study shows rapid healing of heart damage with cell therapy

A scientific technique that rapidly increases the body's production of anti-inflammatory cells promoted healing from heart attacks in mice, according to a new study by investigators from the Smidt Heart Institute at Cedars-Sinai. Once adapted to treat humans, the technique could potentially be used to repair heart muscle damage after a heart attack and be applied to a variety of inflammatory disorders.

26 Mar 2025

Study develops fused neural organoids with leptomeninges

A new study in the peer-reviewed journal Stem Cells and Development describes the development of a co-culture system of neural organoids generated from human induced pluripotent stem cells (iPSCs) fused with fetal leptomeninges from mice with fluorescently labeled meninges, called leptomeningeal neural organoid (LMNO) fusions.

26 Mar 2025

Heart structure changes and their impact on organ function

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The heart is the central organ of the human circulatory system. Both congenital and acquired structural changes in the heart can lead to hemodynamic alterations affecting the function of various organs, including the brain.

26 Mar 2025

Global analysis of antimicrobial resistance in Campylobacter

Announcing a new article publication for Zoonoses journal. The zoonotic pathogen Campylobacter is a major foodborne bacterial species worldwide. The distribution and drivers of antimicrobial resistance (AMR) in global Campylobacter strains remain largely unknown. Therefore, a comprehensive analysis of longitudinal trends and driving factors of AMR in Campylobacter is necessary at a global level.

26 Mar 2025

Study shows red wine biomarkers in urine can predict inflammation levels

Researchers found that specific metabolites of resveratrol in urine accurately reflect red wine consumption. These biomarkers were linked to reduced inflammation in older adults at cardiovascular risk, unlike traditional food surveys.

25 Mar 2025

INTEGRA Biosciences details the evolution and future of serological pipetting

INTEGRA Biosciences has played a pivotal role in advancing the field of serological pipetting over the last 40 years, and has just created a fascinating article covering the fast-paced history of serological pipet controller development.

25 Mar 2025

Epigenetic scores offer new insights into cardiometabolic disease prevention

A new study explores how epigenetic markers-chemical modifications that influence gene activity-can help predict the risk of developing cardiometabolic diseases and guide personalized prevention strategies.

25 Mar 2025

Why Mānuka isn't the only healing honey from New Zealand anymore

New research from Auckland University of Technology reveals that eight native New Zealand honeys, beyond mānuka, possess unique antioxidant, antibacterial, and bioactive properties. Thyme and beech honeydew stood out for their vitamin C and polyphenol content.

25 Mar 2025

Stanford study reveals glucose's surprising role in cell differentiation

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process by which stem cells give rise to specialized cells that make up all the body's tissues.

25 Mar 2025

Researchers unlock key process for regenerating intestinal cells after injury

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

25 Mar 2025

Breakthrough DNA delivery system could revolutionize chronic disease treatment

A breakthrough in safely delivering therapeutic DNA to cells could transform treatment for millions suffering from common chronic diseases like heart disease, diabetes, and cancer.

25 Mar 2025

New open-source tool identifies aging cells to help fight chronic diseases

For human health, prematurely aging cells are a big problem. When a cell ages and stops growing, its function changes, which can cause or worsen cardiovascular disease, Alzheimer's disease and other chronic diseases.

25 Mar 2025

C. diff uses toxic compound to gain competitive advantage in the gut

The pathogen C. diff - the most common cause of health care-associated infectious diarrhea - can use a compound that kills the human gut's resident microbes to survive and grow, giving it a competitive advantage in the infected gut.

25 Mar 2025

Novel global cooperative phenomena of cell interactions discovered in cervical cancer cells

A Japanese research team has discovered a novel global cooperative phenomena of cell interactions in cervical cancer cells. Their findings suggest that the cells are metabolically connected in a functional network.

25 Mar 2025

Scientists find links between bipolar disorder and rare loss-of-function variants in two genes

Scientists at deCODE genetics, a subsidiary of Amgen, reveal today in Nature Genetics associations between bipolar disorder and rare loss-of-function variants in two genes.

25 Mar 2025

Research identifies pressure-sensing protein behind gut motility

After every meal, the intestines perform an action called peristalsis - moving food through their hollow interiors with coordinated contractions and relaxations of the smooth muscle.

25 Mar 2025

ELRIG announces Prof Rory Johnson and Dr Shalini Andersson as keynote speakers at Therapeutic Oligonucleotides 2025

ELRIG, a not-for-profit, volunteer-led organization for the drug discovery community, today announced the keynote speakers for Therapeutic Oligonucleotides 2025 taking place at the AstraZeneca R&D site in Gothenburg, Sweden from 14-15 May. Prof Rory Johnson, Associate Professor, University College Dublin, and Dr Shalini Andersson, Vice President Nucleic Acid Therapeutics, AstraZeneca will lead this year's event focused on 'drugging the undruggable'.

25 Mar 2025

Ancient appetite-control molecule found in starfish and humans

A team of biologists at Queen Mary University of London has discovered that a neurohormone controlling appetite in humans has an ancient evolutionary origin, dating back over half a billion years.

24 Mar 2025