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Novel CRISPR-based technology for rapidly screening genes to understand human health and disease

Zebrafish- small, fast-growing creatures who share many of the same genes as humans- are instrumental to many biologists, who find them uniquely well suited for studying a wide range of questions, from how organisms develop to how the nervous system drives behavior.

20 Aug 2021

Bristol scientists show how laboratory evolution can give rise to highly efficient enzymes

Researchers at the University of Bristol have shown how laboratory evolution can give rise to highly efficient enzymes for new-to-nature reactions, opening the door for novel and more environmentally friendly ways to make drugs and other chemicals.

20 Aug 2021

Researchers use ancient mammalian proteins to develop mRNA delivery system

Using a family of mammalian proteins adopted from ancient retroviral legacy genes, researchers have developed a novel system for programmable intracellular mRNA delivery.

20 Aug 2021

Npas4 gene may be a master timekeeper for the brain's circadian clock

A gene called Npas4, already known to play a key role in balancing excitatory and inhibitory inputs in brain cells, appears to also be a master timekeeper for the brain's circadian clock, new research led by UT Southwestern scientists suggests.

20 Aug 2021

Research could enable clinicians to produce patient-matched cells for treating muscle-related diseases

Investigators who previously developed a recipe for turning skin cells into primitive muscle-like cells that can be maintained indefinitely in the lab without losing the potential to become mature muscle have now uncovered how this recipe works and what molecular changes it triggers within cells.

19 Aug 2021

Genetic nurture has a significant effect on child's educational success, study finds

A child's educational success depends on the genes that they haven't inherited from their parents, as well as the genes they have, according to a new study led by UCL researchers.

19 Aug 2021

Researchers discover glycan 'gates' that open to allow SARS-CoV-2 entry

Since the early days of the COVID pandemic, scientists have aggressively pursued the secrets of the mechanisms that allow severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter and infect healthy human cells.

19 Aug 2021

Scientists develop a new way to deliver molecular therapies to cells

Researchers from MIT, the McGovern Institute for Brain Research at MIT, the Howard Hughes Medical Institute, and the Broad Institute of MIT and Harvard have developed a new way to deliver molecular therapies to cells.

19 Aug 2021

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

19 Aug 2021

Researchers identify antibodies that could protect against alphaviruses

Alphaviruses - mosquito-borne viruses that can trigger brain infections and arthritis - may have met their match.

19 Aug 2021

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

Three independent studies in the Journal of Pharmaceutical Analysis explore the potential uses and applications of quantitative analytical tools in the characterization and quality assessment of biological and medicinal compounds.

19 Aug 2021

Arteriolar niche used by breast cancer cells to prepare for metastasis

More than 43,000 American women will die from breast cancer this year. Most of those deaths will occur after the cancer has spread to other organs, a process called metastasis. This involves at least five major steps.

19 Aug 2021

Memory of specific events does not deteriorate with age in cuttlefish

Cuttlefish can remember what, where, and when specific events happened - right up to their last few days of life, researchers have found.

18 Aug 2021

Auditory and speech processing occur in parallel in the brain

After years of research, neuroscientists have discovered a new pathway in the human brain that processes the sounds of language.

18 Aug 2021

Remote controlling of CAR-T cells with heat to precisely target tumors

A team of researchers led by bioengineers at the Georgia Institute of Technology is expanding the precision and ability of a revolutionary immunotherapy that is already transforming oncology. CAR T-Cell therapy has been hailed by patients, clinical-researchers, investors, and the media as a viable cure for some cancers.

18 Aug 2021

Videos capture the inexorable spread of SARS-CoV-2 in live animals

Video images capture for the first time in live animals the inexorable spread of the COVID-19 virus, tracking the infection as it moved from the noses of mice to the lungs and other organs over the course of six days, in a new study led by researchers at Yale and Université de Montréal.

18 Aug 2021

Study shows how mesenchymal stromal cells regulate factors driving inflammation in COPD patients

A new phase I clinical study shows, for the first time, how treatment with a type of stem cell called mesenchymal stromal cells is able to regulate important factors driving inflammation in patients with chronic obstructive pulmonary disease (COPD) for a period for time.

18 Aug 2021

CRISPR screening tool pinpoints new therapeutic target to treat acute myeloid leukemia

A CRISPR screening tool identified a new therapeutic target to treat acute myeloid leukemia (AML) that has the potential to leave patients with fewer side effects than current approaches, according to a new study from Penn Medicine published online in Molecular Cell.

18 Aug 2021

Scientists propose innovative method to test the effectiveness of coronavirus medicines

South Ural State University scientists have proposed an innovative method for testing the effectiveness of medicines for coronavirus. According to the researchers, it is necessary to focus on the maximum coincidence of the ligand and the receptor. The results of the work have been published in the highly-rated journal "Molecules"(Q1).

18 Aug 2021

New assay using fresh uncultured lung tumor cells could guide personalized treatments

A new study from the University of Helsinki shows that cells that are freshly isolated from lung cancers can be used to create robust drug response data. This approach can identify actionable or non-responsive treatments, illustrated by a case study in which the assay was used to guide the compassionate treatment of a patient.

18 Aug 2021

Life Science News

Novel CRISPR-based technology for rapidly screening genes to understand human health and disease

Bristol scientists show how laboratory evolution can give rise to highly efficient enzymes

Researchers use ancient mammalian proteins to develop mRNA delivery system

Npas4 gene may be a master timekeeper for the brain's circadian clock

Research could enable clinicians to produce patient-matched cells for treating muscle-related diseases

Genetic nurture has a significant effect on child's educational success, study finds

Researchers discover glycan 'gates' that open to allow SARS-CoV-2 entry

Scientists develop a new way to deliver molecular therapies to cells

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

Researchers identify antibodies that could protect against alphaviruses

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

Arteriolar niche used by breast cancer cells to prepare for metastasis

Memory of specific events does not deteriorate with age in cuttlefish

Auditory and speech processing occur in parallel in the brain

Remote controlling of CAR-T cells with heat to precisely target tumors

Videos capture the inexorable spread of SARS-CoV-2 in live animals

Study shows how mesenchymal stromal cells regulate factors driving inflammation in COPD patients

CRISPR screening tool pinpoints new therapeutic target to treat acute myeloid leukemia

Scientists propose innovative method to test the effectiveness of coronavirus medicines

New assay using fresh uncultured lung tumor cells could guide personalized treatments

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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