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Structure of BRCA2 protein complex critical for DNA repair solved

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.

13 Aug 2021

Novel CRISPR-based technique could inspire a new class of medical diagnostics

Scientists have repurposed the genetic modification technology CRISPR to identify antibodies in patient blood samples in a move that could inspire a new class of medical diagnostics in addition to a host of other applications.

13 Aug 2021

Biomedical scientists need to do more to improve the relevance, reproducibility of cell culture research

There is an urgent need for reporting of biomedical research on mammalian cells to be more standardized and detailed and for greater control and measurement of the environmental conditions of cell cultures.

13 Aug 2021

Researchers develop a new way to tag tumor cells to understand cancer treatment resistance

Despite tremendous advances in medicine, tumors are challenging to cure because they are made up of heterogeneous cells.

13 Aug 2021

Study uncovers a subset of human short introns spliced out by a distinct mechanism

The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins.

13 Aug 2021

Researchers identify genetic program in fruit fly that protects neurons from degeneration

Researchers at the University of Bonn have identified a previously unknown genetic program in the fruit fly. The genetic material involved controls the development of the neurons while also protecting them from degeneration.

13 Aug 2021

Researchers develop silica nanostructure for selective synthesis of enantiomers in cells

As COVID-19 vaccinations are well underway, people await a return to normal life. However, fears also grow due to unforeseen side effects like rare thrombosis. In the body, life is maintained by the movement of substances or energy.

13 Aug 2021

Researchers discover how PARP inhibitors selectively kill BRCA-mutant cancer cells

A team of Massachusetts General Hospital researchers has discovered how an important class of anti-cancer drugs called PARP inhibitors works, a finding that could help improve treatment and prolong survival for patients with breast cancer and other malignancies.

12 Aug 2021

Innovative therapeutic platform for blood-to-brain delivery of antisense oligonucleotide therapy

Antisense oligonucleotide (ASO) therapy has the potential to ameliorate many neurodegenerative diseases at the genetic level to suppress the production of harmful proteins or non-coding RNAs.

12 Aug 2021

Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication

In a new study, Chen-Yu Zhang's group from Nanjing University presents a rather striking finding that four circulating miRNAs, which are high in healthy people and much lower in older people and diabetic patients, could effectively inhibit SARS-CoV-2 replication by directly targeting the S protein.

12 Aug 2021

Researchers determine the structure of receptor involved in type 2 diabetes and other pathologies

Researchers from the University of Southern California, Merck & Co., Skoltech, MIPT, UCLA, and the Université de Sherbrooke have determined the structure of the human leukotriene B4 receptor 1, involved in inflammatory, infectious, allergic, and tumorigenic diseases.

12 Aug 2021

Study finds new pair of gene variants that causes sudden onset of hypertension in pregnant women

An international study, led by researchers from Queen Mary University of London and St Bartholomew's Hospital, has found a unique pair of gene variants that causes sudden onset high blood pressure in pregnant women.

12 Aug 2021

Link between high-fat diet, gut microbiota and cardiovascular disease revealed

A high-fat diet disrupts the biology of the gut's inner lining and its microbial communities - and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.

12 Aug 2021

Researchers identify human sperm mutations that can cause disease in children

Throughout development, life and the processes of aging, all human cells accumulate mutations, resulting in what is called mosaicism, a condition in which different cells in the same person have different DNA sequences or genetic makeup.

12 Aug 2021

Study unlocks genetic treasure chest for chronic kidney disease

Despite impacting an estimated 850 million people and being responsible for 1 in 60 deaths worldwide, few treatments are available for chronic kidney disease.

12 Aug 2021

Study finds novel approach to attenuate mitochondrial dysfunction that drives diet-induced obesity

A team of University of California, Irvine, scientists have discovered a novel pharmacological approach to attenuate the mitochondrial dysfunction that drives diet-induced obesity.

12 Aug 2021

UC San Diego scientists develop new method to keep cultured cells healthy

Hematopoietic stem cells — the precursors to blood cells — have been notoriously difficult to grow in a dish, a critical tool in basic research.

12 Aug 2021

Skin cells could provide better understanding of molecular mechanisms of frontotemporal dementia

A new study from the University of Eastern Finland suggests that skin fibroblasts from frontotemporal dementia patients may be useful in investigating underlying disease mechanisms as well as in biomarker and drug research.

12 Aug 2021

Joint commitment process of apes mirrors patterns similar to humans

When we're talking to another person, we probably wouldn't leave without saying goodbye; that would just be impolite.

11 Aug 2021

Study uncovers molecular mechanisms that promote cell-to-cell adhesion and communication

A study led by Northwestern Medicine investigators has identified the molecular mechanisms within protein complexes that promote cell-to-cell adhesion and communication, according to findings published in the Proceedings of the National Academy of Sciences.

11 Aug 2021

Life Science News

Structure of BRCA2 protein complex critical for DNA repair solved

Novel CRISPR-based technique could inspire a new class of medical diagnostics

Biomedical scientists need to do more to improve the relevance, reproducibility of cell culture research

Researchers develop a new way to tag tumor cells to understand cancer treatment resistance

Study uncovers a subset of human short introns spliced out by a distinct mechanism

Researchers identify genetic program in fruit fly that protects neurons from degeneration

Researchers develop silica nanostructure for selective synthesis of enantiomers in cells

Researchers discover how PARP inhibitors selectively kill BRCA-mutant cancer cells

Innovative therapeutic platform for blood-to-brain delivery of antisense oligonucleotide therapy

Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication

Researchers determine the structure of receptor involved in type 2 diabetes and other pathologies

Study finds new pair of gene variants that causes sudden onset of hypertension in pregnant women

Link between high-fat diet, gut microbiota and cardiovascular disease revealed

Researchers identify human sperm mutations that can cause disease in children

Study unlocks genetic treasure chest for chronic kidney disease

Study finds novel approach to attenuate mitochondrial dysfunction that drives diet-induced obesity

UC San Diego scientists develop new method to keep cultured cells healthy

Skin cells could provide better understanding of molecular mechanisms of frontotemporal dementia

Joint commitment process of apes mirrors patterns similar to humans

Study uncovers molecular mechanisms that promote cell-to-cell adhesion and communication

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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