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AI-designed drug shows promise for inflammatory bowel disease

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announces positive results from two Phase I studies in Australia and China of ISM5411, a novel gut-restricted and PHD specific Inhibitor designed and optimized with the support of Insilico's Chemistry42 commercially-available generative reinforcement learning platform, for Inflammatory Bowel Disease (IBD).

8 Jan 2025

High blood pressure may not harm brains of 90-year-olds, study finds

A study led by the University of California, Irvine has found cardiovascular conditions such as high blood pressure and diabetes, which are known to contribute to brain blood vessel damage in younger populations, not to be associated with an increased risk of such harm in individuals 90 and older.

8 Jan 2025

Scientists discover new target for treating aggressive brain cancer

A study co-led by UCLA scientists has found targeting a protein called endocan and its related signaling pathway could be a promising new approach for treating glioblastoma, an aggressive and lethal type of brain cancer.

8 Jan 2025

Construction workers face higher suicide risk, study finds

Male construction workers have a 50 percent higher risk of suicide attempts and suicide. This is shown in a study conducted at the University of Gothenburg.

8 Jan 2025

Study reveals shocking delays in child mental health care

Children and young people with high levels of mental health needs are struggling to receive the help they need, or to have their difficulties recognized, according to a new study.

8 Jan 2025

Ketogenic diet leads in metabolic health improvements for diabetic patients

Study compares the effects of very-low-calorie ketogenic and Mediterranean diets on gut microbiota, metabolic health, and weight management in patients with newly diagnosed type 2 diabetes and obesity.

7 Jan 2025

Bioactive compounds in coffee and tobacco may combat Parkinson’s disease

Tobacco and coffee contain bioactive compounds that may reduce Parkinson's disease risk by targeting key pathways such as MAO B inhibition, α-synuclein aggregation, and neuroinflammation.

7 Jan 2025

U.S. wastewater treatment fails to address rising organofluorine contamination

Municipal wastewater treatment plants remove less than 25% of extractable organofluorine, with fluorinated pharmaceuticals dominating contaminants and posing significant risks to U.S. drinking water quality.

7 Jan 2025

Can fluoride affect IQ? Study points to risks but raises questions

Despite finding a link between fluoride exposure and lower IQ, the study’s flaws raise questions.

7 Jan 2025

Study highlights delays in mental health support for children and young people

Children and young people with high levels of mental health needs are struggling to receive the help they need, or to have their difficulties recognized, according to a new study.

7 Jan 2025

Study reveals significant increase in recreational ketamine use among adults

A recent study analyzing data from the National Survey on Drug Use and Health (NSDUH) found that past-year recreational ketamine use among adults has increased dramatically since 2015, including significant shifts in associations with depression and sociodemographic characteristics such as race, age and education status.

7 Jan 2025

UCLA launches program to help autistic adults navigate dating

Love doesn't come with an instruction manual, but for autistic adults seeking to navigate the complexities of romance, a UCLA Health program offers a roadmap to finding and sustaining meaningful relationships through the launch of a new research study, called PEERS for Dating.

7 Jan 2025

Key actions identified to improve post-acute care for TBI patients

A new systematic literature search identified the highest priority clinical actions aimed at improving post-acute care for non-hospitalized traumatic brain injury (TBI). The study is published in the peer-reviewed Journal of Neurotrauma.

7 Jan 2025

Researchers enhance longevity of neural implants with protective coating

Neural implants contain integrated circuits (ICs) — commonly called chips — built on silicon. These implants need to be small and flexible to mimic circumstances inside the human body.

7 Jan 2025

Early detection of breast cancer proven cost-effective for Canada's health care system

Cancer screening is key to saving patients' lives since an earlier stage diagnosis improves survival rates, decreases morbidity, and leads to less intensive treatments.

7 Jan 2025

AI-based method predicts progression of autoimmune diseases

Autoimmune diseases, where the immune system mistakenly attacks the body's own healthy cells and tissues, often have a preclinical stage before diagnosis that's characterized by mild symptoms or certain antibodies in the blood.

7 Jan 2025

AI-based tool identifies subtypes of Type 2 diabetes using glucose monitors

Diabetes has long been lumped into two categories - Type 1, which often appears in childhood, or Type 2, which is associated with obesity and typically develops later in life. But scientists have learned that not all patients with Type 2 diabetes are the same, with some patients varying in body weight, age of onset and other characteristics.

7 Jan 2025

Morning coffee drinkers have better heart health and lower mortality risk

People who drink coffee in the morning have a lower risk of dying from cardiovascular disease and a lower overall mortality risk compared to all-day coffee drinkers, according to research published in the European Heart Journal today.

7 Jan 2025

Prolonged sauna exposure without adequate hydration linked to heat stroke risk

Basking too long in a sauna may put bathers at risk of heat stroke, particularly if they haven't drunk enough water beforehand, warn doctors in the journal BMJ Case Reports, after treating a woman whose condition required admission to hospital.

7 Jan 2025

Heart attack recovery enhanced by human stem cell spheroids, study shows

In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem cells, or hiPSCs, that overexpress cyclin D2 and are knocked out for human leukocyte antigen classes I and II.

7 Jan 2025