Bend Memorial Clinic to begin Phase III lung cancer trial

The Bend Memorial Clinic is recruiting patients for a Phase III lung cancer trial aimed at preventing the disease’s recurrence in previously treated patients. Specifically, the trial is evaluating the potential of an immunotherapy called Antigen-Specific Cancer Immunotherapeutic (ASCI) for the treatment of Non-Small Cell Lung Cancer (NSCLC).

The study entitled MAGRIT (MAGE-A3 as Adjuvant Non-Small Cell LunG CanceR ImmunoTherapy) is expected to be one of the largest Phase III trials ever conducted in NSCLC. Bend Memorial Clinic will join some 400 centers in more than 33 countries worldwide in this clinical research effort.

MAGE-A3 ASCI is an investigational compound and it is not approved for use in any indication in any country at this time. With a target enrollment of 2,270 patients, the randomized, double-blind, and placebo-controlled MAGRIT trial will enroll patients who demonstrate the MAGE-A3 biomarker and who are assessed as stage IB, II or IIIA resectable NSCLC. The ASCI administration will be initiated in patients after surgery and standard chemotherapy, and also in patients who only receive surgery as a standard of care. The primary endpoint of the trial is disease-free survival.

ASCI is an investigational class of cancer immunotherapy agent aimed at educating the patient’s immune system to identify cancer cells in a specific manner. This investigational cancer immunotherapy is developed using tumor-specific antigens.

“This study is a global undertaking and we really are looking for patients to consider enrolling,” said Bill Schmidt, oncologist at Bend Memorial Clinic. “To reach our enrollment target of 2,270 patients, we’ll need to screen more than 13,000 patients worldwide. The Bend Memorial Clinic is an active player in this trial and we are seeking patients to take part.”


 Bend Memorial Clinic


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