A Virology Lab in Children’s Hospital No. 1 (CH1), Ho Chi Minh City,
Vietnam, sponsored by National Cheng Kung University Hospital (NCKUH)
and National Health Research Institutes (NHRI) in Taiwan was launched on
November 11th, 2009.
Prof. Ih-Jen Su, former Director General of Center for Disease Control
(CDC), Taiwan, and current Deputy Superintendent for Research of
National Cheng Kung University Hospital and Distinguished Investigator
of Division of Infectious Disease in National Health Research
Institutes, is recognized for uplifting medical care and research and
enhancing the public’s well being in Vietnam with the prestigious Ho Chi
Minh Medal Award and Honorous Citizenship of Ho Chi Minh City.
Prof. Da Hsuan Feng, Senior Executive Vice President of NCKU, praised
Prof. Su’s long term humanitarian devotion in Taiwan and abroad. Prof.
Su commented that he simply follows his dream since youth and has
strived to fulfill his mission as an intellectual by serving the public
with his medical expertise. Being known to the Taiwanese public as an
authority on pandemic affairs since SARS and in the current H1N1 flu,
Prof. Su, an expert on biology and pathology of malignant lymphoma,
particularly EBV-associated T cell lymphoma, pathogenesis and mechanism
of HBV pre-S mutants and hepatocarcinogenesis, and pathogenesis and
therapy of virus-associated hemophagocytic syndrome, said in the coming
3-5 years he and his team will continue to explore hepatitis B (HBV) and
hepatocellular carcinoma (HCC). Recently Prof. Su and his team have made
another breakthrough in HBV and HCC research which will revolutionize
Since 2001 NCKUH and CH1 have started research collaboration on dengue
hemorrhagic fever (DHF) with technical support from World Health
Organization (WHO). In 2003, Prof. Ih-Jen Su and Prof. Ching-Chuan Liu
provided technical support for CH1’s study on lymphoma and Epstein-Bar
Virus infection, and in 2006, an official 3-year research project on
hand, foot and mouth disease (HFMD) and hemophagocytic
lymphohistiocytosis was initiated among the three institutions.
So far, a Treatment Guideline for Hand, Foot and Mouth Disease has been
institutionalized by Ministry of Health in Vietnam, a workshop on
hemophagocytic syndrome was held in Feb. 2008, a paper entitled
“Comprehensive analyses and characterization of haemophagocytic
lymphohistocytosis in Vietnamese children” will soon be published in the
British Journal of Haematology, and two papers on dengue hemorrhagic
fever have been published in international medical journals.
Other achievements from this bilateral collaboration include exchange
training program where one surgeon, one cardiologist and one physician
on extracorporeal perfusion from CH1 came to NCKUH to receive a 6 months
long training, two technicians received molecular diagnosis training and
one doctor and one technician received viral isolation training, plus
pathology and hematology training at NCKUH and NHRI. CH1 also benefited
in capacity building on both clinical management and laboratory
investigations, especially in virology.
NCKUH has also sent three pediatric residents to learn infectious
disease and participated in a 10-day training course on dengue
hemorrhagic fever in CH1.
Prof. Su’s major research interest is on the pathogenesis and targeted
therapy of virus-associated malignancies, including EBV-associated T
cell lymphoma and hemophagocytic syndrome and HBV-related hepatocellular
carcinoma. He has identified that EBV can infect T cells and cause T
cell lymphoma and hemophago-cytic syndrome. His team clarified the
signal pathway and target for therapy. They identified the HBV pre-S
mutants as the potential oncoproteins through the ER stress signals. By
identifying the specific signal pathway, they can apply PPAR agonists
and NFkB inhibitors for the prevention and therapy of these
virus-associated immune disorders and human cancers.
Prof. Su’s laboratory is the leading group in the study of
EVB-associated T cell lymphoma and hemophagocytic syndrome in the world.
They first identified KSHV / HHV-8 in non-AIDS Kaposi’s sarcoma. Their
group also first identified HBV pre-S mutants in ground glass
hepatocytes and clarified the biologic significance and its potential
role in hepatocarcinogenesis. He has published a total of more than 200
papers in the journals like Lancet, Blood, Journal of Clinical
Investigation, and Am. J. Pathol. During the SARS period, he served as
the Director General of Taiwan CDC. He also coordinates the task force
for infectious diseases like influenza, enteroviruses, HIV, and
SOURCE National Cheng Kung University Hospital