Data shows Victoza produces greater reductions in A1c, body weight and FPG than Januvia

Late-breaking Novo Nordisk (NVO) extension data presented today at the 70th Annual Scientific Sessions of the American Diabetes Association (ADA) showed that once-daily Victoza® in combination with metformin produced sustained and significantly greater reductions in A1c, body weight and fasting plasma glucose (FPG) than Januvia® plus metformin at 52 weeks.

Key findings from the study include:

  • Patients treated with 1.2 mg and 1.8 mg of Victoza® experienced greater reductions in A1c than those treated with Januvia® 100 mg (-1.3% and -1.5% versus -0.9%)
  • Victoza® provided greater weight loss versus patients treated with Januvia® (2.8 kg [6.16 lbs] and 3.7 kg [8.14 lbs] for 1.2 mg and 1.8 mg respectively, 1.2 kg [2.64 lbs] for Januvia®)
  • Victoza® provided greater change from baseline FPG readings than those treated with Januvia® (-1.7 mmol/L and -2.0 mmol/L for 1.2 mg and 1.8 mg respectively, versus -0.6 mmol/L)
  • Patients treated with Victoza® 1.8 mg reported significantly greater treatment satisfaction than those treated with Januvia®

"What is so encouraging about these data is that Victoza® at both doses was more effective than Januvia® at achieving blood sugar control in people with type 2 diabetes over a period of one year.  Patients who began the trial with higher A1c levels achieved greater reductions in A1c with treatment with Victoza®," said Dr. Richard Pratley, of the Diabetes and Metabolism Translational Medicine Unit, University of Vermont College of Medicine, Burlington.  "Although Victoza® is not indicated for the management of obesity, the study showed that Victoza® provided greater weight loss than Januvia®, which is a benefit for those patients struggling to maintain a healthy weight."

In addition, significantly more patients treated with Victoza® achieved the ADA recommended A1c target of <7.0%.  Nearly twice as many study participants on Victoza® reached the ADA goal compared to the Januvia® group (50% and 63% in the 1.2mg and 1.8mg Victoza® groups versus 27% in the Januvia® group).

Comments

  1. germaine saroukhan germaine saroukhan Lebanon says:

    Sirs.I am a 42 years old lady, saw an endocrinologist and prescribed Victoza for me but after using it for 3 days now am so afraid it might cause any serious problem to my health ,,my blood tests showed my sugar level normal ,,should  stop it or should i continue!!! the Dr confirmed its ok to use it at least for 3 weeks to help me lose weight,,please i need information for people using Victoza for (WEIGHT LOSS)
    thank you in advance
    germaine saroukhan
    beirut
    lebanon

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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