Mar 25 2011
Masimo (Nasdaq: MASI) announced today that three new studies presented at the International Symposium of Intensive Care and Emergency Medicine (ISICEM) Annual Meeting in Brussels, Belgium, demonstrate the accuracy, reliability, and clinical impact of Masimo noninvasive and continuous measurements—noninvasive hemoglobin (SpHb®), Pleth Variability Index (PVI®), and Perfusion Index (PI)—in Intensive Care Unit (ICU) patients.
"Accuracy of a Continuous Noninvasive Hemoglobin Monitor in Intensive Care Unit"
Researchers at the Centre Hospitalier Universitaire in Poitiers, France compared the absolute and trend accuracy of Masimo noninvasive hemoglobin (SpHb) to other invasive methods of hemoglobin assessment—including a point of care device (HemoCue301), a satellite lab CO-Oximeter (Siemens RapidPoint 450), and a 'gold-standard' laboratory hematology analyzer (Sysmex XT-2000i)—in 62 critically-ill ICU patients requiring 471 invasive blood samples. Compared to the gold-standard Sysmex hematology analyzer, results showed a bias and limits of agreement for Masimo noninvasive SpHb of 0.0+/-1.0g/dL. Compared to the gold-standard hematology analyzer, the invasive HemoCue301 and RapidPoint 450 had a bias and limits of agreement of 0.3+/-1.3 g/dL and 0.9+/-0.6 g/dL, respectively. Citing "absolute and trending accuracy similar to widely used invasive methods," researchers concluded that Masimo SpHb has "the additional advantages of providing continuous measurements, noninvasively, which may facilitate hemoglobin monitoring in the ICU."
"Pleth Variability Index Predicts Fluid Responsiveness in Critically-ill Patients"
To evaluate whether Masimo PVI, a noninvasive and continuous tool, can help clinicians predict fluid responsiveness in mechanically-ventilated patients with circulatory insufficiency, researchers at the Centre Hospitalier Universitaire in Poitiers, France measured PVI in 40 patients before and after planned volume expansion. Fluid challenge consisted of either 500mL of 130/0.4 hydroxyethyl-starch (fluid) if respiratory variations in arterial pulse pressurePVI can predict fluid responsiveness noninvasively in ICU patients under mechanical ventilation."
"Perfusion Index as a Predictor for Central Hypovolemia in Humans"
In this study—the first to evaluate the ability of Masimo PI to detect peripheral vasoconstriction due to neurohumoral response in central hypovolemia-induced by lower body negative pressure (LBNP)—researchers from Erasmus MC University Medical Centre in Rotterdam, Netherlands measured PI in 24 healthy volunteers during LBNP testing. LBNP consisted of 5 min. baseline measurements in the supine position followed by stepwise increases of negative pressure from 0 to -20, -40, -60, -80, and o mmHg. Results showed that PI decreased significantly by 40%sensitive indicator of acute hemodynamic responses to LBNP-induced central hypovolemia" and could "detect hypovolemia earlier than 20% decrease in stroke volume."
SpHb, PVI, and PI are available as part of Masimo rainbow® SET platform—the first-and-only technology to noninvasively and continuously measure total hemoglobin (SpHb®), oxygen content (SpOC™), carboxyhemoglobin (SpCO®), methemoglobin (SpMet®), Pleth Variability Index (PVI®), perfusion index (PI), and acoustic respiration rate (RRa™), in addition to the 'gold standard' Measure-Through Motion and Low Perfusion performance of Masimo SET® oxyhemoglobin (SpO2), and pulse rate (PR).