Sequenom launches iPLEX ADME PGx panel to genotype polymorphisms

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Sequenom, Inc. (NASDAQ: SQNM), a life sciences company providing innovative genetic analysis solutions, today announced the launch of its iPLEX ADME PGx panel developed to genotype polymorphisms in genes associated with drug absorption, distribution, metabolism, and excretion (ADME). This Research Use Only (RUO) panel contains a set of pre-designed single nucleotide polymorphisms (SNP), insertions and deletions (INDELS) and copy number variation (CNV) assays for use in the investigation of variants with demonstrated relevance to drug metabolism. After detection on the MassARRAY (RUO) system, the proprietary software solution is then used to score and qualify polymorphisms to create a unique haplotype report.

"Sequenom customers have been successful in developing assays for a wide variety of ADME biomarkers, and numerous high-impact studies have been published using Sequenom technology," said Michael Monko, Senior Vice President, Genetic Analysis. "The iPLEX ADME PGx panel should help scientists quickly and reliably screen samples for genotypes relevant to drug metabolism, speeding the discovery of relevant genotypic markers associated with specific drug treatments."

The iPLEX ADME PGx panel should enable the basic and translational research communities to rapidly and accurately investigate pharmacogenetic biomarkers associated with drug metabolism. The iPLEX ADME PGx panel enables the analysis of 192 polymorphisms across 36 pharmacogenetically relevant genes. The panel uses Sequenom's iPLEX Gold biochemistry together with specific ADME oligonucleotides. The PGx panel consists of 200 assays in 8 wells requiring 10 ng of input DNA per well from fresh or frozen whole blood or cells.

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