Blaze Bioscience to initiate first Phase 1 clinical study of BLZ-100 in patients with skin tumors

Blaze Bioscience, Inc. and its subsidiary, Blaze Bioscience Australia Pty Ltd, today announced the initiation of the first Phase 1 clinical study of the first Tumor Paint product candidate, BLZ-100. The study, titled "A Phase I Dose Escalation/Expansion Study of BLZ-100 Administered by Intravenous Injection in Adult Subjects with Skin Cancer," will enroll up to 30 patients with basal cell carcinoma, squamous cell carcinoma, or amelanotic melanoma. The primary objective is to evaluate the safety and tolerability of BLZ-100 after a single intravenous injection of BLZ-100 administered prior to surgery. The study will also examine the pharmacokinetics of BLZ-100 and the fluorescent signal from skin tumors.

"Initiation of the first-in-human clinical trial just a little over two years after moving the technology out of my lab at the Fred Hutchinson Cancer Research Center is a tremendous accomplishment and marks a major milestone in the development of the Tumor Paint platform," said Jim Olson, M.D., Ph.D., co-founder of Blaze.

"Skin cancer surgery is just one of many cancer surgery settings that we think could benefit from real-time fluorescent imaging using BLZ-100," said Dennis Miller, Ph.D., Senior Vice President of Development. "Blaze anticipates initiating a U.S. clinical program in additional tumor types by the end of 2014."

The study will be conducted at two sites: Q-Pharm Pty Limited and the dermatology clinic of Specialist Connect Pty Limited, both located in Brisbane, Queensland, Australia. Dr. Lynda Spelman of Specialist Connect is the Principal Investigator. Dr. Lauren Kunde and Dr. Paul Griffin are co-investigators.

SOURCE Blaze Bioscience, Inc.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Omega-3 fatty acids found to significantly reduce acne in new study