F2G Limited, the antifungal research and development company today announced a major milestone in the development of its novel IV/ oral systemic antifungal (F901318) with the commencement of a Phase I clinical study. This study initiates the IV Phase I clinical development of F901318 with the oral programme expected to commence in the near future.
F901318 is being developed by F2G to treat invasive aspergillosis and other life-threatening fungal infections and is of a novel class of antifungals acting against a new cellular target. The discovery and development of F901318 represents a major advance in the treatment of serious fungal disease as currently there are very limited treatment options and resistance to existing drugs is becoming a serious problem. F901318 is highly active against all known azole-resistant aspergilli.
Dr Tony Kennedy, F2G’s Chief Scientific Officer said:
We are delighted to commence our clinical development of F901318 based on encouraging preclinical safety and efficacy studies and I look forward to rapidly progressing both our oral and IV programmes.
Ian Nicholson, F2G’s CEO commented:
F901318 is a significant addition to the antifungal armamentarium as there have not been any new classes of antifungal agents s approved for many years and growing resistance presents a considerable challenge in this seriously ill patient population. We believe that F901318 represents a truly innovative approach in this area and we are dedicated to providing improved treatment options for patients with life threatening aspergillus infections.