Repair defect in neurons hints at possible therapy for preventing ALS

Houston Methodist researchers have discovered a repair defect in nerve cells that send messages to the brain, opening the door to a possible therapy for preventing or slowing down ALS. Also known as Lou Gehrig's disease, ALS is a terminal illness marked by rapidly progressive muscle weakness that ultimately affects a person's ability to swallow and breathe.

Led by Muralidhar Hegde, Ph.D., and Haibo Wang, Ph.D., the team described their findings in an article titled "Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis" in the Sept. 11 issue of Nature Communications. The new pathway they uncovered suggests that a DNA Ligase-targeted therapy may prevent or slowdown disease progression.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
Non-invasive brain-machine interface helps chronic paraplegics to regain their walking ability