First gene therapy operation for macular degeneration is a success

A woman treated at Oxford Eye Hospital has become the first person in the world to undergo a gene therapy operation that could combat the most common cause of vision loss in the Western World.

Picture of woman focusing on eyeMotortion Films | Shutterstock

The treatment is the first to target the underlying genetic cause of age-related macular degeneration (AMD), which affects more than 600,000 people in the UK alone.

An 80-year old woman is the first of ten patients with AMD to undergo the procedure as part of a clinical trial of the treatment’s safety.

Her vision will now be regularly monitored to see whether the operation has been successful. The participants in this trial have already suffered some vision loss, but if the treatment proves to be successful, the aim would be to treat people with AMD before they have suffered sight loss and stop the disease in tracks.

A genetic treatment administered early on to preserve vision in patients who would otherwise lose their sight would be a tremendous breakthrough in ophthalmology and certainly something I hope to see in the near future."

Robert MacLaren, Surgeon

In AMD, genes involved in the eye’s natural defense system (the complement system) start to malfunction. This causes cells in the central part of the retina (the macula) to die and they are never renewed. Eventually, a person starts to lose their central vision and the ability to see fine details.

In this pioneering operation, MacLaren injected a virus carrying a synthetic gene into the back of the patient’s eye.

The virus entered retinal cells and released the gene, helping the eye to make a protein that prevents retinal cell death. This keeps the macula healthy.

“We’re harnessing the power of the virus, a naturally occurring organism, to deliver the DNA into the patient’s cells,” says MacLaren.

If successful, the operation could have a significant impact on the quality of life and independence of those who suffer from AMD.

The idea of this gene therapy is to ‘deactivate’ the complement system, but at a very specific point at the back of the eye, so the patient would otherwise be unaffected by it, and we hope that in future it will slow down the progression of macular degeneration.”

Robert MacLaren, Surgeon

Source

Gene therapy first to 'halt' most common cause of blindness

Sally Robertson

Written by

Sally Robertson

Sally has a Bachelor's Degree in Biomedical Sciences (B.Sc.). She is a specialist in reviewing and summarising the latest findings across all areas of medicine covered in major, high-impact, world-leading international medical journals, international press conferences and bulletins from governmental agencies and regulatory bodies. At News-Medical, Sally generates daily news features, life science articles and interview coverage.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Robertson, Sally. (2019, February 20). First gene therapy operation for macular degeneration is a success. News-Medical. Retrieved on August 22, 2019 from https://www.news-medical.net/news/20190220/First-gene-therapy-operation-for-macular-degeneration-is-a-success.aspx.

  • MLA

    Robertson, Sally. "First gene therapy operation for macular degeneration is a success". News-Medical. 22 August 2019. <https://www.news-medical.net/news/20190220/First-gene-therapy-operation-for-macular-degeneration-is-a-success.aspx>.

  • Chicago

    Robertson, Sally. "First gene therapy operation for macular degeneration is a success". News-Medical. https://www.news-medical.net/news/20190220/First-gene-therapy-operation-for-macular-degeneration-is-a-success.aspx. (accessed August 22, 2019).

  • Harvard

    Robertson, Sally. 2019. First gene therapy operation for macular degeneration is a success. News-Medical, viewed 22 August 2019, https://www.news-medical.net/news/20190220/First-gene-therapy-operation-for-macular-degeneration-is-a-success.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post