Overweight and obesity have become a severe public health problem around the world. Current anti-obesity strategies are mainly aimed at restricting calorie intake and absorption. Now, Chinese scientists suggest in a new study that burning energy by activation of brown adipose tissue (BAT) might be an alternative strategy for combating obesity.
The researchers found that an extract from ginseng, a Traditional Chinese Medicine (TCM) herb, can induce Enterococcus faecalis, which can produce an unsaturated long-chain fatty acid (LCFA) - myristoleic acid (MA).
As a novel anti-obesity probiotic, E. faecalis and MA can reduce adiposity via BAT activation and beige fat formation.
JIN Wanzhu, lead author of the study and a scientist at the Institute of Zoology of the Chinese Academy of sciences
Previous studies have shown that BAT facilitates weight control and generates a potent anti-obesity effect. Therefore, increasing BAT activity could be a novel and effective therapeutic approach for obesity and its related diseases, said JIN.
This is the first proof that the E. faecalis LCFA (specifically MA) axis can reduce obesity by increasing BAT activity and beige fat formation.
"This study demonstrates the important role of MA in reducing obesity and improving related metabolic syndrome, as well as its tremendous application prospects," said JIN.
Results of the study, "Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation," were published online in the journal Gut on Nov. 19.
Quan, L-H. et al. (2019) Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. doi.org/10.1136/gutjnl-2019-319114