Researchers use zeolite nanocrystals to deliver oxygen to brain tumors

Glioblastoma, the most widespread and lethal primary brain tumor in adults, is notoriously difficult to treat due to the surrounding lack of oxygen essential to the effectiveness of current treatment.

A team of CNRS and University of Caen Normandie researchers have successfully delivered the necessary oxygen to the tumor using zeolite nanocrystals.

While inhaling oxygen supplies only healthy brain tissue, the nanoparticles are able to target the tumor itself, whose growth causes damage to the barrier separating the brain from the circulatory system.

This allows nanocrystals delivered intravenously to reach the tumor. The researchers also demonstrated that nanozeolites are harmless both to other cells and animals.

The oxygen-rich nanocrystals have been shown to be effective in increasing oxygenation of the glioblastoma. This proof of concept paves the way for future improvements to existing treatments. The study was recently published online in Biomaterials with a print version expected in October 2020.

Source:
Journal reference:

Anfray, C., et al. (2020) Nanosized zeolites as a gas delivery platform in a glioblastoma model. Biomaterials. doi.org/10.1016/j.biomaterials.2020.120249.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
AI outperforms radiologists in brain tumor diagnosis