Iodine derivative kills SARS-CoV-2 within 90 sec

The severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), which is the causative agent of the coronavirus disease 2019 (COVID-19), is often transmitted to others through respiratory droplets from saliva and nasal fluid. When an individual is infected with COVID-19, these tiny droplets contain SARS-CoV-2 viral particles that have a diameter within the range of 0-10 micrometers (µm).

Infected respiratory droplets can be produced during talking, sneezing, coughing, and panting by an infected individual, and can remain viable in aerosols for up to 3 hours. As a result, this mechanism of transmission has been primarily responsible for the rapid spread of COVID-19 across the world, causing over 190 million confirmed SARS-CoV-2 infections and more than 4 million deaths as of July 20, 2021.

Study: Efficacy of “Essential Iodine Drops” against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2). Image Credit: bluecrayola / Shutterstock.com

The antiviral activity of iodine

While mitigation measures such as lockdowns, masking, social distancing, and vaccines have been adopted to reduce the transmission of SARS-CoV-2, several other methods of reducing and controlling the virus have been proposed. Oral and nasal sprays with antiviral activity against SARS-CoV-2, for example, are actively being studied. More specifically, an Intranasal Povidone-Iodine (PVP-I; 1.25%) spray has been found to be active against SARS-CoV-2, as well as SARS-CoV and the Middle East Respiratory Syndrome (MERS).

“Iodine is established as having a broad-spectrum antimicrobial activity against bacterial, viral, fungal, and protozoal pathogens and has been used as an antiseptic for the prevention of infection and the treatment of wounds for decades.”

A recent study published in PLOS One estimated the virucidal efficacy of Essential Iodine Drops (EID) for oral/nasal decontamination of known or suspected cases of COVID-19 as a potentially better alternative to the PVP-I.

The superior activity of EID

Zoltán Köntös, a researcher from IOI Investment Zrt., in Budapest, Hungary, recently demonstrated the efficacy of iodine against SARS-CoV-2 as a better alternative to Povidone-Iodine. In this work, Dr. Köntös found that Iodine-V, which is currently available as the EID formulation, inactivated 99% of SARS-CoV-2 after 60 and 90 seconds. These results were similar to PVP-I, which has previously been reported to inhibit 99.99% of SARS-CoV-2 at 60 seconds.

“Iodine-V offers an advantage as a nasal or oral antiseptic to reduce viral transmission from known or suspected COVID-19 patients.”

While the current study established that EIDs are as efficacious as PVP-I against SARS-CoV-2, it also discussed it as a potentially safer alternative to PVP-I, as this agent is known to cause serious rashes despite being non-cytotoxic. When used as a preoperative antiseptic in oral and maxillofacial surgery, for example, PVP-I is often associated with late-onset allergic contact dermatitis in some patients due to the free iodine that has an oxidizing effect on the skin or mucosa.

The improved safety profile of EID is largely due to the significantly lower amount of iodine present in this formulation as compared to that which is found in PVP-I. EID, for example, is an aqueous solution of Iodine-V containing 200 micrograms (μg) of elemental iodine/milliliter (ml). This is comparable to 1-5% PVP-I, which often contains 1000–5000 μg/ml iodine.

In addition to the therapeutic benefits of EID against SARS-CoV-2, the Iodine-V in EID also serves as a mineral supplement that can maintain healthy thyroid functioning.

“Being already on the market as a mineral supplement to help people with iodine deficiency, it is safe when used routinely orally or intranasally in known or suspected COVID-19 patients.”

Conclusion

Taken together, the current study concluded that being excipient-free, Iodine-V is likely to have better stability and an enhanced potency in vivo when compared with PVP-I against SARS-CoV-2. The study, therefore, recommends the use of intranasal/oral Iodine-V to reduce the risk of transmitting SARS-CoV-2.

Journal reference:
Dr. Ramya Dwivedi

Written by

Dr. Ramya Dwivedi

Ramya has a Ph.D. in Biotechnology from the National Chemical Laboratories (CSIR-NCL), in Pune. Her work consisted of functionalizing nanoparticles with different molecules of biological interest, studying the reaction system and establishing useful applications.

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Comments

  1. Richard Denis Jones Richard Denis Jones United Kingdom says:

    You should send a copy of this article to Boris (PM)

  2. Richard Noakes Richard Noakes Australia says:

    You have two choices - you can go with the viruses, vaccines, lot - or you can follow my simple and free virus cure, so that you NEVER get Covid anything, which is where the money is!!
    "Even so, a key issue is that the current vaccines block severe disease but do not prevent infection, said Dr. Gregory Poland, a vaccine scientist at the Mayo Clinic. That is because the virus is still capable of replicating in the nose, even among vaccinated people, who can then transmit the disease through tiny, aerosolized droplets"
    Reuters - what my free salt water cure stops.

    The Achilles Heel of Coronavirus, is while it is still in the developing stage as Coronavirus/Covid in the warm, wet areas inside the nasal passages of your head (nose) and before it gets to become Covid in your head and lungs, 10 to 14 days later. If Coronavirus is not treated with my free salt clean water cure to flush out your nasal passages, as soon as possible, or during self isolation, it becomes Covid, which is where the money is. You cannot catch Covid! Always breathe through your nose and keep your mouth shut, because you really don't want the Coronavirus to seed itself in your lungs!! My free salt water cure has "absolutely nothing" to do with mRNA test vaccines. Treating Coronavirus with my free salt clean water cure, flushes out the nasal cavity and kills Coronavirus, before it gets to be Covid, irrespective of if you have had mRNA vaccines or not. Mix one heaped teaspoon of salt in a mug of warm or cold clean water, cup a hand and pour some of the solution in, then sniff or snort that mugful up into your nose, spitting out everything which comes down into your mouth, by so doing, you flush out your nasal cavity, where Coronavirus lives. If you get a burning sensation (which lasts for 2-3 minutes) then you have a Coronavirus infection.When the soreness goes away, blow out your head with toilet paper and flush away, washing your hands afterwards and continue doing my salt clean water nasal cavity flush cure, morning, noon and night, or more often, if you want, until, when you do my free salt water cure, you don't experience any soreness at all in your nasal cavity. While you are at it, swallow a couple of mouthfulls and if you get a burning sensation in your chest, then you are killing the Covid/Bronchitis there too, so keep it up, each time you do a salt water sniffle, until the soreness in your head and lungs goes away - job done. Pour some of the solution on a flat surface and allow to dry and see what you have then. This is what coats the nasal passages in your head and kills Coronavirus/Covid off. You can see why it is so effective. This is what I have done for the past 26.5 years and I am NEVER ill, nor do you need to be either.
    Please pass it around to everyone who wants to give it a try.

    He added that “Current vaccines are great at preventing [CO1] serious infection deep in the lungs, but not at blocking infection in the upper airways. What's needed is a nasal-spray (vaccine) that would stop the coronavirus from taking hold at all.” - what my free salt water cure does and stops.
    The iodine in the salt kills Coronavirus dead, long before it gets to be Covid anything

    Keep safe. Richard

    • Lynn Lavalette Lynn Lavalette United States says:

      You have us make a mug of your salt solution, then say to "snort that mugful into your nose" from your palms.
      1. Did you really mean for us to snort up the entire "mugful" each time, or just a few snorts? Pls clarify.
      Than, you say to "swallow a couple of mouthfuls" to "clean out the lungs".
      2. Swallowing anything doesn't go into the lungs, because the swallowing tube to the stomach is separate from the breathing tube to the lungs. Pls clarify what you meant to say.
      The 2 above points make me hope that you simply chose the wrong wording and will clarify. Without that, anyone who follows you is a fool.
      And I see someone else asked for help with making the solution & you didn't reply. That's likely because we have no way to contact Richard, the man who has this nasal/oral salt solution therapy. And he hasn't returned so doesn't know of the now 2 comments awaiting his response. Too bad, as this makes sense to me but without clarifying, it's useless.

  3. John Hasse John Hasse United States says:

    For those of us who are not chemistry majors:  HOW do you make a solution with 200 micrograms per milliliter???

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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