Stem cell transplantation produces prolonged survival with improved safety in patients with AL amyloidosis

AL amyloidosis is a life-threatening disease related to bone marrow cancer, multiple myeloma. It is caused when a person's antibody-producing white blood cells (i.e. plasma cells) do not function properly and generate abnormal protein which misfolds to form amyloid fibrils and deposits made of components of antibodies called light chains, which then deposit in various organs of the body.

For some and highly selected patients, treatment includes high-dose chemotherapy (melphalan) and autologous (one's own) stem cell transplantation (HDM/SCT).

In the largest study of its kind, researchers from the Boston University/Boston Medical Center Amyloidosis Center have found that HDM/SCT produces prolonged survival with improved safety in patients with AL amyloidosis. Additionally, they have for the first time developed a predictive score to assess event free survival following stem cell transplantation. Event-free survival is defined as the time between stem cell transplantation and initiation of next line of therapy or death, whichever occurs first.

This data highlights a continued role for time tested HDM/SCT in the treatment paradigm of transplant-eligible patients with AL amyloidosis. This treatment, first developed here at BU/BMC in the 1990s, leads to long term survival especially for those who achieve a complete hematologic response after SCT."

Vaishali Sanchorawala, MD, corresponding author, director of the Boston University/Boston Medical Center Amyloidosis Center

The researchers reviewed collected data from a prospectively maintained database of patients with AL amyloidosis consecutively treated with HDM/SCT between July 1994 and September 2021.They found that hematologic complete remission (CR) was achieved in 39 percent of patients with a median overall survival of 15 years with 30 percent of these patients survived greater than 20 years.

"The risk of future hematologic relapse was also low (five percent) amongst patients with a sustained hematologic CR for 15 years, suggesting that the majority of patients who reach this milestone may be operationally cured by HDM/SCT," added Sanchorawala.

The researcher also developed a prognostic score for event free survival which incorporated measuring the patients' light chain levels and bone marrow plasma cell percentage. Patients with low-risk (0 factors), intermediate-risk (1 factor), and high-risk (2 factors) disease had median event-free survival estimate of 5.3, 2.8 and 1 years, respectively.

Source:
Journal reference:

Gustine, J.N., et al. (2022) Predictors of hematologic response and survival with stem cell transplantation in AL amyloidosis: A 25-year longitudinal study. American Journal of Hematology. doi.org/10.1002/ajh.26641.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Implantable device revolutionizes thyroid management