Study may one day lead to a new treatment for preventing cerebral palsy

Severe brain injury that develops slowly after preterm births, causing the likes of cerebral palsy, may be treatable, new research from the University of Auckland finds.

Over a third of cases of cerebral palsy are still linked to being born extremely prematurely. Clinical studies have shown that severe injury can appear many weeks after birth.

The current thinking is that this form of brain injury is so severe that there is no point trying to understand it, let alone treat it. Just the concept that it might be treatable is revolutionary."

Dr Christopher Lear, Senior Research Fellow, Study Lead Author

The University of Auckland team showed, in an animal model, that there was intense local inflammation before the injury developed.

Critically, giving the well-established anti-inflammatory drug, Etanercept (also known as 'Enbrel') three days after a period of oxygen deprivation was able to almost completely prevent severe injury from developing after three weeks' recovery. The article has just been published in a leading journal, Brain. "Virtually all proposed treatments so far need to be started within the first six hours of life," says Professor Laura Bennet. "This is often not realistic when families are overwhelmed by events around birth."

"A therapeutic window of at least three days is exceptionally long. Much more research is needed before this approach can be tested in humans, but this remarkably wide window for treatment gives us real hope that these findings will one day lead to a new treatment in humans to prevent cerebral palsy," says Professor Bennet.

The team are from the Fetal Physiology and Neuroscience Group in the Department of Physiology.

This research was supported by a 2017 programme grant of $4,919,534 from the Health Research Council of New Zealand (HRC).

Source:
Journal reference:

Lear, C.A., et al. (2022) Tumour necrosis factor blockade after asphyxia in foetal sheep ameliorates cystic white matter injury. Brain. doi.org/10.1093/brain/awac331.

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